Supplemented Gegen Qinlian Decoction Formula attenuates podocyte mitochondrial fission and renal fibrosis in diabetic kidney disease by inhibiting TNF-α-mediated necroptosis, compared with empagliflozin

Autor: Wang, Yu, Yu, Lu, Li, Yajing, Cha, Siyu, Shi, Lijing, Wang, Jinlong, Ge, Fengfeng, Huang, Chubo, Huang, Huang, Tu, Yue, Wan, Yigang, Shen, Shanmei

Publikováno v: In Journal of Ethnopharmacology 15 November 2024 334

The aqueous extract of Lycopus lucidus Turcz exerts protective effects on podocytes injury of diabetic nephropathy via inhibiting TGF-β1 signal pathway

Autor: Xie, Shengfang, Ge, Fengfeng, Yao, Yuanzhang, Zhang, Wei, Wang, Shuopeng, Zhang, Min, Zhong, Rongling, Fang, Liming, Qu, Ding

Diabetic nephropathy (DN) is known as a major microvascular complication leading cause of end-stage renal disease, it generally followed by the process of podocyte fragmentation and detachment. Transforming growth factor β1 (TGF-β1) signaling pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2be6f888f465d61eaff7279abf3f3731
https://europepmc.org/articles/PMC6789289/

The aqueous extract of Lycopus lucidus Turcz exerts protective effects on podocytes injury of diabetic nephropathy via inhibiting TGF-β1 signal pathway.

Autor: Xie S; Department of Nephrology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Nephrology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Ge F; Department of Nephrology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Nephrology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Yao Y; Department of Nephrology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Nephrology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Zhang W; Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Wang S; Department of Nephrology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Nephrology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Zhang M; Department of Nephrology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Nephrology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Zhong R; Animal Experiment Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Animal Experiment Center, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Fang L; Department of Nephrology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Department of Nephrology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China., Qu D; Research Center for Multicomponent Traditional Medicine and Microecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, Jiangsu, China.; Research Center for Multicomponent Traditional Medicine and Microecology, Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, Jiangsu, China.

Publikováno v: American journal of translational research [Am J Transl Res] 2019 Sep 15; Vol. 11 (9), pp. 5689-5702. Date of Electronic Publication: 2019 Sep 15 (Print Publication: 2019).