Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gb3 synthase"'
Autor:
Marina Beraza-Millor, Julen Rodríguez-Castejón, Jonatan Miranda, Ana del Pozo-Rodríguez, Alicia Rodríguez-Gascón, María Ángeles Solinís
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1936 (2023)
Substrate reduction therapy (SRT) has been proposed as a new gene therapy for Fabry disease (FD) to prevent the formation of globotriaosylceramide (Gb3). Nanomedicines containing different siRNA targeted to Gb3 synthase (Gb3S) were designed. Formulat
Externí odkaz:
https://doaj.org/article/cd7f99f4f05048b184df3aae8ce1768f
Akademický článek
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Autor:
Ora A. Weisz, Anatalia Labilloy
Publikováno v:
Kidney international. 96(2)
The ability of proximal tubule cells to internalize filtered proteins over a broad concentration range is essential for maintaining a protein-free urine but also renders these cells uniquely susceptible to cytotoxic damage. Morace et al. find that kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459c7bc9acac18b04313e64d9ea80681
https://pubmed.ncbi.nlm.nih.gov/31101366
https://pubmed.ncbi.nlm.nih.gov/31101366
Autor:
Hidekatsu Yoshioka, Koichi Furukawa, Chikara Shiozuka, Ryoji Hamanaka, Kozue Uchio-Yamada, Satoshi Ishii, Kazuaki Mannen, Takanori Kunieda, Junichiro Matsuda, Shinji Yano, Ashok B. Kulkarni, Atsumi Taguchi, Yoko Noguchi, Shigeo Yokoyama
Publikováno v:
Journal of Biochemistry. 149:161-170
Fabry disease is a lysosomal storage disorder caused by an α-galactosidase A (α-Gal A) deficiency and resulting in the accumulation of glycosphingolipids, predominantly globotriaosylceramide (Gb3). A transgenic mouse expressing the human α-Gal A R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d6e702d1e42e5427e86a98e3bd7b2b
https://doi.org/10.1093/jb/mvq125
https://doi.org/10.1093/jb/mvq125
Autor:
Jong-Seo Shin, In-Sun Shin, Kyong-Il Sung, Hyun-Yong Jang, Satoshi Ishii, Byong-Wan Kim, Byung-Sung Park
Publikováno v:
BMB Reports. 42:310-314
Globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) are the proposed functional receptors for Shiga toxin (Stx). To elucidate the effect of Gb3 content on Stx-induced cytotoxicity in HeLa cells, we cloned HeLa cells and determined the correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7f7c9b1b5358f1f64ae9032e9f59fb
https://doi.org/10.5483/bmbrep.2009.42.5.310
https://doi.org/10.5483/bmbrep.2009.42.5.310
Autor:
Kamani, Mustafa
Glycosphingolipid (GSL) metabolism is a complex process involving proteins and enzymes at distinct locations within the cell. Mammalian GSLs are typically based on glucose or galactose, forming glucosylceramide (GlcCer) and galactosylceramide (GalCer
Externí odkaz:
http://hdl.handle.net/1807/35860
Publikováno v:
Gastroenterology. 120:A327-A327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d60409655daa3555cd3c9bd44e834cc
https://doi.org/10.1016/s0016-5085(01)81625-5
https://doi.org/10.1016/s0016-5085(01)81625-5
Akademický článek
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