Influence of Microenvironmental Orchestration on Multicellular Lung Alveolar Organoid Development from Human Induced Pluripotent Stem Cells.

Autor: Ozan VB; Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland., Wang H; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.; Department of Rheumatology and Immunology Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Akshay A; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland.; Functional Urology Research Group, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Anand D; Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Hibaoui Y; Department of Gynecology and Obstetrics, Cantonal Hospital Fribourg, Fribourg, Switzerland., Feki A; Department of Gynecology and Obstetrics, Cantonal Hospital Fribourg, Fribourg, Switzerland., Gote-Schniering J; Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.; Department of Rheumatology and Immunology Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Gheinani AH; Functional Urology Research Group, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.; Department of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Urological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Heller M; Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Uldry AC; Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Lagache SB; Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Gazdhar A; Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Geiser T; Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. thomas.geiser@insel.ch.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. thomas.geiser@insel.ch.

Publikováno v: Stem cell reviews and reports [Stem Cell Rev Rep] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo

Autor: Petra Khan, Kleanthis Fytianos, Sabrina Blumer, Julien Roux, Amiq Gazdhar, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Sofia Mykoniati, Michael Tamm, Thomas Geiser, Katrin E. Hostettler

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

In idiopathic pulmonary fibrosis (IPF), basal-like cells are atypically present in the alveolar region, where they may affect adjacent stromal cells by paracrine mechanisms. We here aimed to confirm the presence of basal-like cells in peripheral IPF

Externí odkaz: https://doaj.org/article/f2ebaa7eeea74c47bb55753b9f5016b3

Electrospray Mediated Localized and Targeted Chemotherapy in a Mouse Model of Lung Cancer

Autor: Paulius Ruzgys, Stephan Böhringer, Ayse Sila Dokumaci, Yvonne Hari, Christian M. Schürch, Frido Brühl, Stefan Schürch, Sönke Szidat, Carsten Riether, Saulius Šatkauskas, Thomas Geiser, David Hradetzky, Amiq Gazdhar

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Background: An advanced stage, centrally localized invasive tumor is a major cause of sudden death in lung cancer patients. Currently, chemotherapy, radiotherapy, laser ablation, or surgical resection if possible are the available state-of-the-art tr

Externí odkaz: https://doaj.org/article/33c12e6764224a9c9a414c5ba0cf11b9

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

Autor: Salome M. Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Jürgen Brinckmann, Ulrich auf dem Keller, Sabine Werner, Mattia R. Bordoli

Publikováno v: Brütsch, S M, Madzharova, E, Pantasis, S, Wüstemann, T, Gurri, S, Steenbock, H, Gazdhar, A, Kuhn, G, Angel, P, Bellusci, S, Brinckmann, J, auf dem Keller, U, Werner, S & Bordoli, M R 2023, ' Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome ', Cellular and Molecular Life Sciences, vol. 80, no. 4, 89 . https://doi.org/10.1007/s00018-023-04735-6
Brütsch, Salome M; Madzharova, Elizabeta; Pantasis, Sophia; Wüstemann, Till; Gurri, Selina; Steenbock, Heiko; Gazdhar, Amiq; Kuhn, Gisela; Angel, Peter; Bellusci, Saverio; Brinckmann, Jürgen; Auf dem Keller, Ulrich; Werner, Sabine; Bordoli, Mattia R (2023). Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome. Cellular and molecular life sciences : CMLS, 80(4), p. 89. Springer 10.1007/s00018-023-04735-6
Cellular and Molecular Life Sciences, 80 (4)

Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory pathway-resident and extracellular matrix proteins. However, its cell-type specific functions in vivo ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e887d224134568655fa90513e229f687
https://orbit.dtu.dk/en/publications/dbe7c0dd-3549-4535-ae10-3a6996507604

Culture of human alveolar epithelial type II cells by sprouting

Autor: Petra Khan, Kleanthis Fytianos, Luca Tamò, Michael Roth, Michael Tamm, Thomas Geiser, Amiq Gazdhar, Katrin E Hostettler

Publikováno v: Respiratory Research, Vol 19, Iss 1, Pp 1-7 (2018)

Abstract Background Type II alveolar epithelial cells (AT2) play a pivotal role in maintaining the integrity and function of the alveoli. Only recently, the role of impaired epithelial repair mechanisms after injury in the pathogenesis of idiopathic

Externí odkaz: https://doaj.org/article/bdf6985e8f5f4ea788a210a636d7bed7