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Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.

Autor: Lee AA; ASAP Discovery Consortium.; PostEra Inc, 1 Broadway, Cambridge MA 02142., Amick I; ASAP Discovery Consortium.; PostEra Inc, 1 Broadway, Cambridge MA 02142., Aschenbrenner JC; ASAP Discovery Consortium.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.; Research Centre at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK., Barr HM; ASAP Discovery Consortium.; The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel., Benjamin J; ASAP Discovery Consortium.; Icahn School of Medicine, Mount Sinai, New York, New York, United States of America., Brandis A; ASAP Discovery Consortium.; Life Sciences Core Facilities, The Weizmann Institute of Science Rehovot 7610001, Israel., Cohen G; The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel., Diaz-Tapia R; ASAP Discovery Consortium.; Icahn School of Medicine, Mount Sinai, New York, New York, United States of America., Duberstein S; ASAP Discovery Consortium.; The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel., Dixon J; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Cousins D; ASAP Discovery Consortium.; MedChemica Consultancy Ltd, Macclesfield, Cheshire, SK11 6DU, UK., Fairhead M; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Fearon D; ASAP Discovery Consortium.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.; Research Centre at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK., Frick J; ASAP Discovery Consortium.; PostEra Inc, 1 Broadway, Cambridge MA 02142., Gayvert J; ASAP Discovery Consortium.; PostEra Inc, 1 Broadway, Cambridge MA 02142., Godoy AS; ASAP Discovery Consortium.; São Carlos Institute of Physics, University of São Paulo, Av. Joao Dagnone, 1100 - Jardim Santa Angelina, Sao Carlos, 13563-120, Brazil., Griffin EJ; ASAP Discovery Consortium.; MedChemica Consultancy Ltd, Macclesfield, Cheshire, SK11 6DU, UK., Huber K; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Koekemoer L; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Lahav N; ASAP Discovery Consortium.; The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel., Marples PG; ASAP Discovery Consortium.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.; Research Centre at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK., McGovern BL; ASAP Discovery Consortium.; Icahn School of Medicine, Mount Sinai, New York, New York, United States of America., Mehlman T; ASAP Discovery Consortium.; Life Sciences Core Facilities, The Weizmann Institute of Science Rehovot 7610001, Israel., Robinson MC; ASAP Discovery Consortium.; PostEra Inc, 1 Broadway, Cambridge MA 02142., Singh U; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Szommer T; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Tomlinson CWE; ASAP Discovery Consortium.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.; Research Centre at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK., Vargo T; ASAP Discovery Consortium.; PostEra Inc, 1 Broadway, Cambridge MA 02142., von Delft F; ASAP Discovery Consortium.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Research Centre at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK., Wang S; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., White K; ASAP Discovery Consortium.; Icahn School of Medicine, Mount Sinai, New York, New York, United States of America., Williams E; ASAP Discovery Consortium.; Centre for Medicines Discovery, University of Oxford, Oxford OX3 7FZ, UK., Winokan M; ASAP Discovery Consortium.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.; Research Centre at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 21. Date of Electronic Publication: 2024 Aug 21.