Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gayoung Jang"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-7 (2023)
Abstract KRAS is the most commonly mutated RAS family gene and is a primary cause of the occurrence of several types of cancer. However, KRAS mutations have several unique and diverse molecular identities, making it difficult to find specific treatme
Externí odkaz:
https://doaj.org/article/2faf4a85fb8f469a8e2220d1d90e7ad6
Autor:
Gayoung Jang, Ha Rim Shin, Hyo-Sang Do, Jiyeon Kweon, Soojin Hwang, Soyoung Kim, Sun Hee Heo, Yongsub Kim, Beom Hee Lee
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 586-595 (2023)
Lesch-Nyhan syndrome (LNS) is inherited as an X-linked recessive genetic disorder caused by mutations in hypoxanthine-guanine phosphoribosyl transferase 1 (HPRT1). Patients with LNS show various clinical phenotypes, including hyperuricemia, gout, dev
Externí odkaz:
https://doaj.org/article/eb6665589bc6414aa635932aaa3cb0f1
Autor:
Jiyeon Kweon, An-Hee Jang, Eunji Kwon, Ungi Kim, Ha Rim Shin, Jieun See, Gayoung Jang, Chaeyeon Lee, Taeyoung Koo, Seokjoong Kim, Yongsub Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 377-384 (2023)
Genome editing: Novel editors for CRISPR-Cas9 technology Tiny genome editors that can fit inside a single delivery system could potentially improve the efficiency and specificity of the editing technology known as CRISPR-Cas9. This technology is used
Externí odkaz:
https://doaj.org/article/5a3318fd8f0248789017a3d9b04bef91
Autor:
Yeon-Sook Choi, Myung Ji Kim, Eun A. Choi, Sinae Kim, Eun ji Lee, Min Ji Park, Mi-Ju Kim, Yeon Wook Kim, Hee-Sung Ahn, Jae Yun Jung, Gayoung Jang, Yongsub Kim, Hyori Kim, Kyunggon Kim, Jin Young Kim, Seung-Mo Hong, Song Cheol Kim, Suhwan Chang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
The major challenges in pancreatic ductal adenocarcinoma (PDAC) management are local or distant metastasis and limited targeted therapeutics to prevent it. To identify a druggable target in tumor secretome and to explore its therapeutic intervention,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2d290ccb8ab9e03ce4c0372d3e8d46
https://pubmed.ncbi.nlm.nih.gov/35858411
https://pubmed.ncbi.nlm.nih.gov/35858411
KRASis the most commonly mutated RAS family gene and is a primary cause of the occurrence of several types of cancer. However,KRASmutations have several unique and diverse molecular identities, making it difficult to find specific treatments. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6edd7d90fad31c5e69e46086f633112
https://doi.org/10.1101/2022.12.21.521522
https://doi.org/10.1101/2022.12.21.521522
Autor:
Jong Il Kim, Jung Ki Yoon, Yongsub Kim, An Hee Jang, Ha Rim Shin, Gayoung Jang, Ji Eun See, Jiyeon Kweon
Publikováno v:
Molecular Therapy. 29:2001-2007
Although prime editors are a powerful tool for genome editing, which can generate various types of mutations such as nucleotide substitutions, insertions, and deletions in the genome without double-strand breaks or donor DNA, the conventional prime e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7a5226cd3a227b9692f17fcbb95fca
https://doi.org/10.1016/j.ymthe.2021.02.022
https://doi.org/10.1016/j.ymthe.2021.02.022
Autor:
Ji-Eun See, Gayoung Jang, Yongsub Kim, Gi-Jun Sung, Kyung-Chul Choi, Jin-Soo Kim, Inki Kim, Heon Seok Kim, Ha Rim Shin, Jiyeon Kweon, An-Hee Jang, Sojung Park
Publikováno v:
Nucleic Acids Research
CRISPR-based base editors (BEs) are widely used to induce nucleotide substitutions in living cells and organisms without causing the damaging DNA double-strand breaks and DNA donor templates. Cytosine BEs that induce C:G to T:A conversion and adenine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7d058dad095b7dd41318342f516d3f
https://doi.org/10.1093/nar/gkab052
https://doi.org/10.1093/nar/gkab052
Publikováno v:
Journal of visualized experiments : JoVE. (168)
Recent studies have investigated the risks associated with BRCA1 gene mutations using various functional assessment methods such as fluorescent reporter assays, embryonic stem cell viability assays, and therapeutic drug-based sensitivity assays. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c920ba3bf193cb2ebeae65f5f02e7fb2
https://pubmed.ncbi.nlm.nih.gov/33720123
https://pubmed.ncbi.nlm.nih.gov/33720123
Publikováno v:
Journal of Visualized Experiments.
Recent studies have investigated the risks associated with BRCA1 gene mutations using various functional assessment methods such as fluorescent reporter assays, embryonic stem cell viability assays, and therapeutic drug-based sensitivity assays. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee329a02f121fc5ae5dc30dc876b7ee
https://doi.org/10.3791/61557
https://doi.org/10.3791/61557
Autor:
Yeon-Sook Choi, Myung Ji Kim, Choi, Eun A., Sinae Kim, Eun ji Lee, Min Ji Park, Mi-Ju Kim, Yeon Wook Kim, Hee-Sung Ahn, Jae Yun Jung, Gayoung Jang, Yongsub Kim, Hyori Kim, Kyunggon Kim, Jin Young Kim, Seung-Mo Hong, Song Cheol Kim, Suhwan Chang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/26/2022, Vol. 119 Issue 30, p1-12, 12p