Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gayoung Baek"'
Autor:
Seonghyun Lee, Hyunji Lee, Gayoung Baek, Eunji Namgung, Joo Min Park, Sanghun Kim, Seongho Hong, Jin-Soo Kim
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract We present two methods for enhancing the efficiency of mitochondrial DNA (mtDNA) editing in mice with DddA-derived cytosine base editors (DdCBEs). First, we fused DdCBEs to a nuclear export signal (DdCBE-NES) to avoid off-target C-to-T conve
Externí odkaz:
https://doaj.org/article/c75833fd6b5a4521bb8a2cc46e75ceef
Publikováno v:
Green Chemistry Letters and Reviews, Vol 14, Iss 3, Pp 455-461 (2021)
The increasing demand for fatty aldehydes as natural flavoring agents nowadays grapples with current production processes requiring harsh reaction conditions and hazardous chemicals. Our research group proved the concept of an innovative, sustainable
Externí odkaz:
https://doaj.org/article/43de2efd806a45088f608468e77b0b59
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.
Externí odkaz:
https://doaj.org/article/ee5911a6b2f44fcc9054d499322a52a3
Autor:
Seonghyun Lee, Jihun Kim, Huiyun Seo, Hyun Ji Lee, Jin-Soo Kim, Beum-Chang Kang, Gayoung Baek, Annie Kim, Jeong Sun Lee, Su-Ji Bae
Publikováno v:
Nature Plants
Plant organelles including mitochondria and chloroplasts contain their own genomes, which encode many genes essential for respiration and photosynthesis, respectively. Gene editing in plant organelles, an unmet need for plant genetics and biotechnolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb85a08c71a7d716b913d1f9da2bf75b
https://doi.org/10.1038/s41477-021-00943-9
https://doi.org/10.1038/s41477-021-00943-9
Publikováno v:
Nature biotechnology.
Bacterial toxin DddA-derived cytosine base editors (DdCBEs)—composed of split DddAtox (a cytosine deaminase specific to double-stranded DNA), custom-designed TALE (transcription activator-like effector) DNA-binding proteins, and a uracil glycosylas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a39c6bbf2bcac51aa1ce41152634a3
https://pubmed.ncbi.nlm.nih.gov/36229610
https://pubmed.ncbi.nlm.nih.gov/36229610
Autor:
Annie Kim, Gayoung Baek, Seonghyun Lee, Beum-Chang Kang, Huiyun Seo, Jin-Soo Kim, Hyun Ji Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
DddA-derived cytosine base editors (DdCBEs), composed of the split interbacterial toxin DddAtox, transcription activator-like effector (TALE), and uracil glycosylase inhibitor (UGI), enable targeted C-to-T base conversions in mitochondrial DNA (mtDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c5f2fb222bd7ba6107e9da3c0d7824
https://doi.org/10.1038/s41467-021-21464-1
https://doi.org/10.1038/s41467-021-21464-1
Publikováno v:
Korean Chemical Engineering Research. 54:698-705
Butyl acetate is produced from acetic acid and butanol via an esterification reaction in reactive distillation (RD). The product, butyl acetate, has been used as an internal entrainer until now. In this case, butyl acetate and water are removed at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4018ec9487c08a6ddc4a5f468bbad7
https://doi.org/10.9713/kcer.2016.54.5.698
https://doi.org/10.9713/kcer.2016.54.5.698
Autor:
Jin-Soo Kim, Seuk Min Ryu, Kyoungmi Kim, Sangtae Kim, Daesik Kim, Gayoung Baek, Kayeong Lim, Eugene Chung, Sung Hyun Kim
Publikováno v:
Nature Biotechnology. 35:435-437
Base editors (BEs) composed of a cytidine deaminase fused to CRISPR-Cas9 convert cytidine to uridine, leading to single-base-pair substitutions in eukaryotic cells. We delivered BE mRNA or ribonucleoproteins targeting the Dmd or Tyr gene via electrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84d21e679255137288ae8b668a819d23
https://doi.org/10.1038/nbt.3816
https://doi.org/10.1038/nbt.3816
Autor:
Da Eun Kim, Sangtae Kim, Seuk Min Ryu, Jin-Soo Kim, Hyun Ji Lee, Heon Seok Kim, Eugene Chung, Kyoungmi Kim, Gayoung Baek, Kayeong Lim, Taeyoung Koo
Publikováno v:
Nature biotechnology. 36(6)
Adenine base editors (ABEs) composed of an engineered adenine deaminase and the Streptococcus pyogenes Cas9 nickase enable adenine-to-guanine (A-to-G) single-nucleotide substitutions in a guide RNA (gRNA)-dependent manner. Here we demonstrate applica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f368880d567c533fb25ca02fa92e8e28
https://pubmed.ncbi.nlm.nih.gov/29702637
https://pubmed.ncbi.nlm.nih.gov/29702637
Autor:
Junseok W. Hur, Jin-Soo Kim, Junho K. Hur, Youn Su Lee, Seuk Min Ryu, Kyung Wook Been, Kyoungmi Kim, Gayoung Baek, Sunghyeok Ye
Publikováno v:
Nature Biotechnology. 34:807-808
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcd28c11e333d6f4dcdc3b4508a0cd5
https://doi.org/10.1038/nbt.3596
https://doi.org/10.1038/nbt.3596