Zobrazeno 1 - 10
of 16 640
pro vyhledávání: '"Gaynor A"'
Autor:
Daniel C. Maddison, Bilal Malik, Leonardo Amadio, Dana M. Bis-Brewer, Stephan Züchner, Owen M. Peters, Gaynor A. Smith
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112883- (2023)
Summary: Coat protein complex I (COPI) is best known for its role in Golgi-endoplasmic reticulum (ER) trafficking, responsible for the retrograde transport of ER-resident proteins. The ER is crucial to neuronal function, regulating Ca2+ homeostasis a
Externí odkaz:
https://doaj.org/article/3e8d02b505624b16a3ce80450c747787
Autor:
Owen M. Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A. Smith, Michael A. Schwarzschild, Christian Mueller, Robert H. Brown, Marc Freeman
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105368- (2021)
Parkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compa
Externí odkaz:
https://doaj.org/article/61bd0e8a5ddc42d987d5cc6ee8708517
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-21 (2019)
Abstract Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic process
Externí odkaz:
https://doaj.org/article/b757efe2e6bd443792bb3df08849d94b
Autor:
Stacey, Joe, Cheng, Jianpeng, Torr, John, Guigue, Tristan, Driesen, Joris, Coca, Alexandru, Gaynor, Mark, Johannsen, Anders
Spurred by recent advances in Large Language Models (LLMs), virtual assistants are poised to take a leap forward in terms of their dialogue capabilities. Yet a major bottleneck to achieving genuinely transformative task-oriented dialogue capabilities
Externí odkaz:
http://arxiv.org/abs/2403.00462
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Leukocyte recruitment is one of the most important cellular responses to tissue damage. Leukocyte extravasation is exquisitely regulated by mechanisms of selective leukocyte-endothelium recognition through adhesion proteins in the endothelial cell su
Externí odkaz:
https://doaj.org/article/bd3b6b78113d445f8ce7337052584077
Autor:
Sophie V. Precious, Gaynor A. Smith, Andreas Heuer, Ines Jaeger, Emma L. Lane, Stephen B. Dunnett, Meng Li, Claire M. Kelly, Anne E. Rosser
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Neural transplantation in neurodegenerative diseases such as Parkinson’s disease (PD) offers to replace cells lost during the progression of the disease process. Primary fetal ventral mesencephalon (VM), the origin of bona fide midbrain dopaminergi
Externí odkaz:
https://doaj.org/article/b68b33a606d4496d942f58d2fff9423c
Autor:
Emily M. Rocha, Gaynor A. Smith, Eric Park, Hongmei Cao, Eilish Brown, Melissa A. Hayes, Jonathan Beagan, Jesse R. McLean, Sarah C. Izen, Eduardo Perez-Torres, Penelope J. Hallett, Ole Isacson
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 495-503 (2015)
Diminished lysosomal function can lead to abnormal cellular accumulation of specific proteins, including α-synuclein, contributing to disease pathogenesis of vulnerable neurons in Parkinson's disease (PD) and related α-synucleinopathies. GBA1 encod
Externí odkaz:
https://doaj.org/article/2ef89fe7a22c4b478cadce9df032959e
Autor:
Emily Belita, Sarah E. Neil-Sztramko, Vanessa De Rubeis, Sheila Boamah, Jason Cabaj, Susan M. Jack, Cory Neudorf, Clemence Ongolo Zogo, Carolyn Seale, Gaynor Watson-Creed, Maureen Dobbins
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background There is limited evidence about the mental health and intention to leave of the public health workforce in Canada during the COVID-19 pandemic. The objectives of this study were to determine the prevalence of burnout, symptoms of
Externí odkaz:
https://doaj.org/article/c42426ceaad648adbda3d26c38948e0a
Autor:
Kendall L. Calhoun, Thomas Connor, Kaitlyn M. Gaynor, Amy Van Scoyoc, Alex McInturff, Samantha E.S. Kreling, Justin S. Brashares
Publikováno v:
Movement Ecology, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Background Movement plays a key role in allowing animal species to adapt to sudden environmental shifts. Anthropogenic climate and land use change have accelerated the frequency of some of these extreme disturbances, including megafire. Thes
Externí odkaz:
https://doaj.org/article/d5a5a03f9a264505820d553c04fdc018
Publikováno v:
Western Journal of Emergency Medicine, Vol 25, Iss 4, Pp 579-583 (2024)
Background: It is an unfortunate truth that Emergency Medicine (EM) physicians will, at some point, have contact with the medicolegal system. However, most EM residency training programs lack education on the legal system in their curriculum, leaving
Externí odkaz:
https://doaj.org/article/ee7864a9e9b14b6080fdbdd19b946a36