Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gayle Yamamoto"'
Autor:
Antonio Miranda, Wayne Kornreich, Gayle Yamamoto, Wylie Vale, Jean Francois Hernandez, Catherine Rivier, Yvette Taché, John S. Andrews, Jean Rivier
Publikováno v:
Journal of Medicinal Chemistry. 36:2860-2867
Two series of CRF antagonists with N alpha- and C alpha-methylated alanine and leucines were evaluated for their biological activities in vitro and in vivo in several systems. The poly-N-methylated analogue of alpha-helical-CRF9-41, [N alpha MeLeu10,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733154240f12438e1720e47d7a596ef8
https://doi.org/10.1021/jm00072a004
https://doi.org/10.1021/jm00072a004
Autor:
Wylie Vale, R. Galyean, Jean Rivier, Charleen Miller, Catherine Rivier, Gayle Yamamoto, Antonio Miranda, A. G. Craig, Marvin R. Brown
Publikováno v:
Journal of Medicinal Chemistry. 36:2851-2859
In an attempt to determine which conformational parameters are important for the biological activity of ovine corticotropin-releasing factor (oCRF), we have synthesized in significant amounts (50-200 mg) and characterized chemically, structurally (CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b5677f5fb9b8228b19a691778be8c0
https://doi.org/10.1021/jm00072a003
https://doi.org/10.1021/jm00072a003
Autor:
Jean Francois Hernandez, Catherine Rivier, Gayle Yamamoto, Wayne Kornreich, Cynthia J. Donaldson, A. G. Craig, Jean Rivier, R. Galyean, Wylie Vale
Publikováno v:
Journal of medicinal chemistry. 35(10)
Previous structure-activity relationship studies of CRF have shown that residues 1-4 were not necessary for receptor binding or transduction, that residues 4-8 were important for activation, and that residues 12-41 were mostly responsible for binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207b4c1e774cc18cc11eb681deac6894
https://pubmed.ncbi.nlm.nih.gov/1316969
https://pubmed.ncbi.nlm.nih.gov/1316969
Publikováno v:
Molecular and Cellular Endocrinology. 37:311-318
The possibility that desensitization to the inhibitory effects of somatostatin (SS) might develop following chronic exposure to this tetradecapeptide was examined in cultured rat anterior pituitary cells. Pretreatment with 1 microM SS for 48 h caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d442920bd6f945492b3851f2bf883cea
https://doi.org/10.1016/0303-7207(84)90101-1
https://doi.org/10.1016/0303-7207(84)90101-1
Autor:
Diane Jolley, Wylie Vale, Hans Seifert, Marilyn H. Perrin, Thomas O. Bruhn, Michael O. Thorner, Jean Rivier, Gayle Yamamoto, Joan Vaughan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30c383ed2c6378189fc465e60b8b069
https://doi.org/10.1016/0076-6879(86)24030-6
https://doi.org/10.1016/0076-6879(86)24030-6
Publikováno v:
Science (New York, N.Y.). 238(4826)
There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of glucocorticoids, the adrenal steroids that mediate important aspects of the response to stress. Specifically, secretion of interleukin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba5bd7f5ad975fddd7f9d3039678b4c
https://pubmed.ncbi.nlm.nih.gov/2821621
https://pubmed.ncbi.nlm.nih.gov/2821621
Publikováno v:
Endocrinology. 112(4)
The effects of synthetic human pancreatic (tumor) GH Releasing Factor, hpGRF, and a partially purified rat hypothalamic GRF, rhGRF, on secretion of GH by primary cultures of rat pituitary cells are reported to be inhibited noncompetitively by somatos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09e1a61aed8445d3d344162ea25f44f
https://pubmed.ncbi.nlm.nih.gov/6131812
https://pubmed.ncbi.nlm.nih.gov/6131812
Corticotropin (ACTH) secretion by the anterior pituitary is stimulated by catecholamines in vivo and in vitro. The nature of the response in vivo is controversial but appears to be mediated by beta-adrenergic receptors, whereas the response is depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09efc65a28a5e669e8a03106d7129611
https://europepmc.org/articles/PMC281797/
https://europepmc.org/articles/PMC281797/
Publikováno v:
Annals of the New York Academy of Sciences. 527
Amidated fragments 1 to 29 of human growth hormone releasing factor, (GRF1-29NH2), were designed to encompass modifications that could prevent degradation by exopeptidases. The NH2-terminus was blocked by either N-methylation of Tyr1 or by introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f53715e4551cadc19fa851083509d9f
https://pubmed.ncbi.nlm.nih.gov/3133968
https://pubmed.ncbi.nlm.nih.gov/3133968
Autor:
Thomas O. Bruhn, Carolyn Douglas, Joan Vaughan, Wylie Vale, Gayle Yamamoto, Jean Rivier, David Dalton, Catherine Rivier
Publisher Summary The corticotropin releasing factor (CRF) can be assayed by a variety of biological and immunological techniques. The chapter describes two methods: an in vitro assay employing primary anterior pituitary cell cultures and a radioimmu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae23b0e0b2e0781fba454a768f03eec
https://doi.org/10.1016/s0076-6879(83)03040-2
https://doi.org/10.1016/s0076-6879(83)03040-2