Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gayle M. Wittenberg"'
Autor:
David M. Kern, Rachel E. Teneralli, Christopher M. Flores, Gayle M. Wittenberg, James P. Gilbert, M. Soledad Cepeda
Publikováno v:
Psychiatric Research and Clinical Practice, Vol 4, Iss 1, Pp 12-20 (2022)
Objective To systematically identify novel pharmacological strategies for preventing or treating post‐traumatic stress disorder (PTSD) by leveraging large‐scale analysis of real‐world observational data. Methods Using a self‐controlled study
Externí odkaz:
https://doaj.org/article/bd6ca9d67bf74e66a848765def5716e3
Autor:
Juan Pablo Lopez, Laura M. Fiori, Cristiana Cruceanu, Rixing Lin, Benoit Labonte, Hannah M. Cates, Elizabeth A. Heller, Vincent Vialou, Stacy M. Ku, Christophe Gerald, Ming-Hu Han, Jane Foster, Benicio N. Frey, Claudio N. Soares, Daniel J. Müller, Faranak Farzan, Francesco Leri, Glenda M. MacQueen, Harriet Feilotter, Kathrin Tyryshkin, Kenneth R. Evans, Peter Giacobbe, Pierre Blier, Raymond W. Lam, Roumen Milev, Sagar V. Parikh, Susan Rotzinger, Steven C. Strother, Cathryn M. Lewis, Katherine J. Aitchison, Gayle M. Wittenberg, Naguib Mechawar, Eric J. Nestler, Rudolf Uher, Sidney H. Kennedy, Gustavo Turecki
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepre
Externí odkaz:
https://doaj.org/article/e95c158a05b749e2a3450c3b601e8593
Autor:
Yuk Yee Leung, Jon B. Toledo, Alexey Nefedov, Robi Polikar, Nandini Raghavan, Sharon X. Xie, Michael Farnum, Tim Schultz, Young Baek, Vivianna M. Van Deerlin, William T. Hu, David M. Holtzman, Anne M. Fagan, Richard J. Perrin, Murray Grossman, Holly D. Soares, Mitchel A. Kling, Matthew Mailman, Steven E. Arnold, Vaibhav A. Narayan, Virginia M‐Y. Lee, Leslie M. Shaw, David Baker, Gayle M. Wittenberg, John Q. Trojanowski, Li‐San Wang, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 3, Pp 339-348 (2015)
Abstract Introduction The dynamic range of cerebrospinal fluid (CSF) amyloid β (Aβ1–42) measurement does not parallel to cognitive changes in Alzheimer's disease (AD) and cognitively normal (CN) subjects across different studies. Therefore, ident
Externí odkaz:
https://doaj.org/article/42989bc2dc9e445d976979ab4e23062a
Autor:
Joan M. Carboni, Ashok Dongre, Ricardo M. Attar, Lee Helman, Edwin Clark, Marco M. Gottardis, Francis Y. Lee, Aixin Li, Douglas Robinson, Jiwen Chen, Karen Reeves, Gayle M. Wittenberg, Rameh Hafezi, Xia Han, Warren Hurlburt, Ann Greer, Fei Huang
Supplementary Figures 1-8 from The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42474490c8ed6a3b377f9e7b43d1f72d
https://doi.org/10.1158/0008-5472.22376792.v1
https://doi.org/10.1158/0008-5472.22376792.v1
Autor:
Joan M. Carboni, Ashok Dongre, Ricardo M. Attar, Lee Helman, Edwin Clark, Marco M. Gottardis, Francis Y. Lee, Aixin Li, Douglas Robinson, Jiwen Chen, Karen Reeves, Gayle M. Wittenberg, Rameh Hafezi, Xia Han, Warren Hurlburt, Ann Greer, Fei Huang
Supplementary Tables 1-4 from The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f233a0b2d7adb3af321b4fc481e4713c
https://doi.org/10.1158/0008-5472.22376789.v1
https://doi.org/10.1158/0008-5472.22376789.v1
Publikováno v:
CNS Drugs
Background Observational data may inform novel drug development programs by identifying previously unappreciated, clinical benefits of existing drugs. Several preclinical and clinical studies have suggested emergent therapeutic utility of drugs actin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27180c894b8cb5c32306d0e98a3119ec
https://doi.org/10.1007/s40263-020-00789-3
https://doi.org/10.1007/s40263-020-00789-3
Autor:
Femke Lamers, Yuri Milaneschi, Robert A. Schoevers, Johannes H Smit, Gayle M. Wittenberg, Brenda W.J.H. Penninx
Publikováno v:
Lamers, F, Milaneschi, Y, Smit, J H, Schoevers, R A, Wittenberg, G & Penninx, B W J H 2019, ' Longitudinal association between depression and inflammatory markers : Results from the Netherlands Study of Depression and Anxiety ', Biological Psychiatry, vol. 85, no. 10, pp. 829-837 . https://doi.org/10.1016/j.biopsych.2018.12.020
Biological Psychiatry, 85(10), 829-837. Elsevier USA
Biological Psychiatry, 85(10), 829-837. ELSEVIER SCIENCE INC
Biological Psychiatry, 85(10), 829-837. Elsevier USA
Biological Psychiatry, 85(10), 829-837. ELSEVIER SCIENCE INC
Background: While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c3a895382d24ae5136891dab29ca16
https://doi.org/10.1016/j.biopsych.2018.12.020
https://doi.org/10.1016/j.biopsych.2018.12.020
Autor:
Mark Curran, Edward T. Bullmore, Benjamin Hsu, Yun Zhang, P S Jagannatha, Gayle M. Wittenberg, Annie Stylianou, Shahid M. Khan, Yu Sun, Anshita Gupta, Guang Chen, D. Wang, Wayne C. Drevets
Publikováno v:
Regan, T 2020, ' Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders ', Molecular Psychiatry, vol. 25, no. 6, pp. 1275-1285 . https://doi.org/10.1038/s41380-019-0471-8
2019, ' Effects of immunomodulatory drugs on depressive symptoms : A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders ', Molecular Psychiatry, vol. 25, 25, pp. 1275–1285 . https://doi.org/10.1038/s41380-019-0471-8
Molecular Psychiatry
2019, ' Effects of immunomodulatory drugs on depressive symptoms : A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders ', Molecular Psychiatry, vol. 25, 25, pp. 1275–1285 . https://doi.org/10.1038/s41380-019-0471-8
Molecular Psychiatry
Activation of the innate immune system is commonly associated with depression. Immunomodulatory drugs may have efficacy for depressive symptoms that are co-morbidly associated with inflammatory disorders. We report a large-scale re-analysis by standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4b7b8f731adb77f8c17abaa7a06881
https://hdl.handle.net/20.500.11820/77528e04-fe09-4878-b2d1-b9a56120ced3
https://hdl.handle.net/20.500.11820/77528e04-fe09-4878-b2d1-b9a56120ced3
Autor:
Christopher M. Flores, Najat Khan, John Halamka, Andrew D. Badley, Gayle M. Wittenberg, Rakesh Barve, Samir Awasthi, Tyler Wagner, Venky Soundararajan, AJ Venkatakrishnan, Anuli Anyanwu-Ofili, Dan Tarjan
Decoding disease mechanisms for addressing unmet clinical need demands the rapid assimilation of the exponentially growing biomedical knowledge. These are either inherently unstructured and non-conducive to current computing paradigms or siloed into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cdc1075d6e8058f761683104805af0
https://doi.org/10.1101/2020.04.03.020602
https://doi.org/10.1101/2020.04.03.020602
Publikováno v:
Biological psychiatry. 88(8)
Whole-genome transcription has been measured in peripheral blood samples as a candidate biomarker of inflammation associated with major depressive disorder.We searched for all case-control studies on major depressive disorder that reported microarray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62ab6826ff76fde4b6d42bb3239528f
https://pubmed.ncbi.nlm.nih.gov/32972515
https://pubmed.ncbi.nlm.nih.gov/32972515