Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gayle M Passmore"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71809 (2013)
The KCNQ2 gene product, Kv7.2, is a subunit of the M-channel, a low-threshold voltage-gated K(+) channel that regulates mammalian and human neuronal excitability. Spontaneous mutations one of the KCNQ2 genes cause disorders of neural excitability suc
Externí odkaz:
https://doaj.org/article/2ceac468bc5b437eb29b3ffad5ad07cf
Autor:
Lydia Jiménez-Díaz, Sandrine M Géranton, Gayle M Passmore, J Lianne Leith, Amy S Fisher, Laura Berliocchi, Anantha K Sivasubramaniam, Anne Sheasby, Bridget M Lumb, Stephen P Hunt
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1961 (2008)
Recent studies have demonstrated the importance of local protein synthesis for neuronal plasticity. In particular, local mRNA translation through the mammalian target of rapamycin (mTOR) has been shown to play a key role in regulating dendrite excita
Externí odkaz:
https://doaj.org/article/bde58bdbd69a4760a0c97652391b70cb
Publikováno v:
Pflugers Archiv
Skin keratinocytes fulfil important signalling and protective functions. Immunocytochemical experiments revealed the unexpected presence of immunoreactivity for the M-type potassium channel subunit Kv7.2 in the keratinocyte layer of intact rat paw sk
Autor:
Gayle M. Passmore, David Brown
Publikováno v:
Journal of Clinical Investigation. 120:1380-1383
Bradykinin is the most potent endogenous inducer of acute pain. However, the way in which it excites nociceptive sensory nerve endings is still unclear. In an article recently published in the JCI, Liu et al. suggest a new mechanism via which bradyki
Autor:
Gayle M. Passmore, David Brown
Publikováno v:
British Journal of Pharmacology. 156:1185-1195
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neur
Autor:
S. J. Marsh, Elizabeth A. Matthews, M. Mistry, Stephen Antony Burbidge, Terry A. Brown, Anthony H. Dickenson, Gayle M. Passmore, David Brown, Martin Main, M AlQatari, A. A. Selyanko
Publikováno v:
The Journal of Neuroscience. 23:7227-7236
Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic pain. M currents [IK(M)] play a key role in regulating neuronal excitability, and mutations in neuronal KCNQ2/3 subunits, the molecular correlates of IK(M), hav
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71809 (2013)
PLoS ONE
PLoS ONE
The KCNQ2 gene product, Kv7.2, is a subunit of the M-channel, a low-threshold voltage-gated K(+) channel that regulates mammalian and human neuronal excitability. Spontaneous mutations one of the KCNQ2 genes cause disorders of neural excitability suc
Autor:
Anthony H. Dickenson, Vanessa N. Keasberry, S. J. Marsh, Joanne M. Reilly, David Brown, Gayle M. Passmore, Matthew Thakur
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 5 (2012)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
M-channels carry slowly activating potassium currents that regulate excitability in a variety of central and peripheral neurons. Functional M-channels and their Kv7 channel correlates are expressed throughout the somatosensory nervous system where th
Autor:
John N. Wood, Marzia Malcangio, Mohammed A. Nassar, Anthony H. Dickenson, Gayle M. Passmore, Fan Wang, Anna K. Clark, Michael S. Minett
Publikováno v:
Nature Communications
Human acute and inflammatory pain requires the expression of voltage-gated sodium channel Nav1.7 but its significance for neuropathic pain is unknown. Here we show that Nav1.7 expression in different sets of mouse sensory and sympathetic neurons unde
Autor:
David A, Brown, Gayle M, Passmore
Publikováno v:
British journal of pharmacology. 156(8)
KCNQ genes encode five Kv7 K(+) channel subunits (Kv7.1-Kv7.5). Four of these (Kv7.2-Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuron