Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gayle Kwon"'
Autor:
Brian Baker, Dan Scott Allison, Lee Hendrix, David Jurchen, Susan Pederson, Heidi Boshaw, Sam Marzolf, Jens J. Billgren, John A. Latham, Vanessa Lisbeth Rubin, Gayle Kwon, Cristina Moldovan Loomis, Leon F. Garcia-Martinez, Pei Fan, Roger Cady, Erica Stewart, Ethan W. Ojala, Charlie Karasek, Jenny Mulligan, Michelle Scalley-Kim, Lisa Perrino McCulloch, Benjamin H. Dutzar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:26-36
Migraine is a debilitating disease that affects almost 15% of the population worldwide and is the first cause of disability in people under 50 years of age, yet its etiology and pathophysiology remain incompletely understood. Recently, small molecule
Autor:
Colin Hall, Elise M. Lewis, Graeme J. Moffat, M. Benjamin Hock, Marc W. Retter, Mark Loomis, Jeanine L. Bussiere, Gary J. Chellman, Gayle Kwon
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:178-188
Understanding species differences in the placental transfer of monoclonal antibodies is important to inform species selection for nonclinical safety assessment, interpret embryo-fetal changes observed in these studies, and extrapolate their human rel
Autor:
Meghan Moore, Marc W. Retter, Sekhar Kanapuram, Mark Loomis, Wei Wang, Graeme J. Moffat, Ian Pyrah, Gayle Kwon, Rhian Davies, Gary J. Chellman
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 48
To assess the potential for male-mediated drug transfer to their female partner and/or developing conceptus, vaginal uptake of a monoclonal antibody (mAb) biotherapeutic was assessed in cynomolgus monkeys. A human IgG2 mAb (IgG2X; bound human and cyn
Autor:
Graeme J, Moffat, Marc W, Retter, Gayle, Kwon, Mark, Loomis, M Benjamin, Hock, Colin, Hall, Jeanine, Bussiere, Elise M, Lewis, Gary J, Chellman
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 101(2)
Understanding species differences in the placental transfer of monoclonal antibodies is important to inform species selection for nonclinical safety assessment, interpret embryo-fetal changes observed in these studies, and extrapolate their human rel
Autor:
Higbee Jared Martin, Bei Shan, Margrit Schwarz, Wen-Chen Yeh, William G. Romanow, Qiong Cao, Mei Lu, Joyce Chi Yee Chan, Richard Zhang, Yongmei Di, Ping Cao, Maurice Emery, Evelyn Yang, Stephen T. Thibault, Lei Zhou, Susan Shetterly, Gayle Kwon, Timothy W. Yu, Dongming Liu, Wenyan D. Shen, Kirk Henne, Oscar Pan, Mei-Mei Tsai, Heather Salomonis, Bryna Fuchslocher, Ziva Arimura, Nigel Walker, Qiang Liu, Mark Daris, Derek E. Piper, Kijeong Lee, Simon Mark Jackson, Wei Wang, Chadwick T. King, Jie Tang, Xiao-Ping Yang, Jackie Sheng, Yan Wang, Marc W. Retter, Zhen Xia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(24)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. We have generated a neutralizing anti-PCSK9 antibody
Autor:
Gary J. Chellman, Gayle Kwon, Graeme J. Moffat, Marc W. Retter, Sekhar Kanapuram, Mark Loomis, Rhian Davies, Ian Pyrah, Meghan Moore
Publikováno v:
Reproductive Toxicology. 48:21