Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gayle E. Taylor"'
Autor:
Xinchun Tong, Melanie Latham, Ying Chen, Denise P. Milot, Milton L. Hammond, Amjad Ali, Eugene Tan, Sheryl A. Hyland, Carl P. Sparrow, Qiu Guo, Joann B. Napolitano, Laurence B. Peterson, Samuel D. Wright, Suoyu S. Xu, Qiaolin Deng, Yi-Heng Chen, Gayle E. Taylor, Zhijian Lu, Peter J. Sinclair, Suzanne S. Eveland, Matt S. Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:199-203
SAR studies of the substitution effect on the central phenyl ring of the biphenyl scaffold were carried out using anacetrapib (9a) as the benchmark. The results revealed that the new analogs with substitutions to replace trifluoromethyl (9a) had a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d23a0727a318e5869d943562cf0bf0
https://doi.org/10.1016/j.bmcl.2011.11.039
https://doi.org/10.1016/j.bmcl.2011.11.039
Autor:
Milton L. Hammond, Anne-Marie Cumiskey, Sheryl A. Hyland, Ray Rosa, Christopher F. Thompson, Amjad Ali, Ying Chen, Suoyu S. Xu, James V. Pivnichny, Xinchun Tong, Qiu Guo, Hong Li, Carl P. Sparrow, Peter J. Sinclair, Joann B. Napolitano, Melanie Latham, Zhijian Lu, Samuel D. Wright, Laurence B. Peterson, Matt S. Anderson, Suzanne S. Eveland, Cameron J. Smith, Gayle E. Taylor, Denise P. Milot
Publikováno v:
Journal of Medicinal Chemistry. 54:4880-4895
The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically, it was found that sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9687b925796a3dc579010acb69a718d
https://doi.org/10.1021/jm200484c
https://doi.org/10.1021/jm200484c
Autor:
Gool F. Patel, Ronald E. Painter, Wayne M. Geissler, Gayle E. Taylor, Georgianna Harris, Lynn L. Silver, Kenneth P. Ellsworth, Richard L. Tolman, Donald W. Graham, Amjad Ali, Katherine Young, Susan D. Aster
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2185-2188
Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in the DNA synthesis of Gram-positive bacteria. Among the analogues, 18 displayed an IC50 of 10mM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf616702c68c1195fa9c619047ea4f11
https://doi.org/10.1016/s0960-894x(01)00407-3
https://doi.org/10.1016/s0960-894x(01)00407-3
Autor:
Paul Mazur, Michael J. Forrest, Joann Williamson, Georgianna Harris, Mark L. Greenlee, Karen Lowitz, Gayle E. Taylor, Silvi Luell, Monica Einstein, Shilpa Pandit, Joseph C. Santoro, Milton L. Hammond, Lan Ge, Greg Rouen, Amjad Ali, Chuanlin Wang, Ester Carballo-Jane, James M. Balkovec, Ayesha Sitlani, Terri M. Kelly, Denise M. Visco
Publikováno v:
Bioorganicmedicinal chemistry. 16(16)
A series of betamethasone 17α-carbamates were designed, synthesized, and evaluated for their ability to dissociate the two main functions of the glucocorticoid receptor, that is, transactivation and transrepression, in rat cell lines. A number of al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e976f4bd615016f17c11fd9b4076b66d
https://pubmed.ncbi.nlm.nih.gov/18691892
https://pubmed.ncbi.nlm.nih.gov/18691892
Autor:
Katherine Young, Georgianna Harris, Lynn L. Silver, Gayle E. Taylor, Ken Ellsworth, Amjad Ali, Ronald E. Painter
Publikováno v:
Journal of medicinal chemistry. 46(10)
6-Anilinopyrazolo[3,4-d]pyrimidin-4-ones are novel dGTP analogues that inhibit the replication-specific enzyme DNA polymerase III (DNA pol III) of Staphlococcus aureus and other Gram-positive (Gr+) bacteria. To enhance the potential of these inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b2f0086b582665d188846257ebaa62
https://pubmed.ncbi.nlm.nih.gov/12723946
https://pubmed.ncbi.nlm.nih.gov/12723946