Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gayathri Sadasivam"'
Autor:
Anand Tarage, Gopal Gole, Mandar Bhonde, Madhusudhan Reddy, Sharad Sharma, Harish Volam, Sudeep Sabde, Sanjeev Anant Kulkarni, Sadanand Mallurwar, Brahmam Sunkara, Ramesh Dattatraya Phadtare, Manoj Dandekar, Hemant Goyal, Samiron Phukan, Gayathri Sadasivam, Rupesh Kanhere, Maneesh Mehta, Nirmal Jana, Murthy Cheemala, Prashant Vidhate, Lal Dinchhana, Prashant B. Nigade, Bernstein Peter Robert, Prajakta Ahirrao, Rajan Goel, Aditya Naik, Vipul Pachpute, Sukanya Patra, Rajender Kumar Kamboj, Nilesh Mahajan, Kaustubh Tamane, Sneha Trivedi, M. K. Singh, Ajit Kumar Marisetti, Shankar Bhagwat, Mahip Verma, Atul Akarte, Dipak Lagad, Charudatt Samant, Venkata P. Palle, Vinod Patil, Anand Bokare, Dipak Modi, Chaitanya A. Kulkarni, Lakshmi Narasimham, Neetinkumar Reddy, Majid Bashir Sayyed, Sarita Koul, Shukla Manojkumar Ramprasad, Milind Gholve, Swati Tota, Vinod D. Chaudhari, Jayasagar Gundu, Manisha Shingare, Sachin J Mahangare, Shashikant Pawar
Publikováno v:
Journal of Medicinal Chemistry. 63:14700-14723
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4614f9af4bf378b9f2f87f030837f97
https://doi.org/10.1021/acs.jmedchem.0c01264
https://doi.org/10.1021/acs.jmedchem.0c01264
Autor:
Amol V. Shivange, Mamatha B. Nijaguna, Gayathri Sadasivam, Vadiraj Kurdekar, Vijay Potluri, Muralidhara Padigaru, Kavitha Bharatham, Jasti Subbarao, Saranya Giridharan, Ashok R. Venkitaraman, Jayaprakash Periasamy, Sanjana Boggaram
Publikováno v:
ChemMedChem. 14:1620-1632
The tandem BRCT domains (tBRCT) of BRCA1 engage phosphoserine-containing motifs in target proteins to propagate intracellular signals initiated by DNA damage, thereby controlling cell cycle arrest and DNA repair. Recently, we identified Bractoppin, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd2b15dd22a1f73a9aee11998c51fa0
https://doi.org/10.1002/cmdc.201900300
https://doi.org/10.1002/cmdc.201900300
Autor:
Manojkumar R, Shukla, Sukanya, Patra, Mahip, Verma, Gayathri, Sadasivam, Nirmal, Jana, Sachin J, Mahangare, Prashant, Vidhate, Dipak, Lagad, Anand, Tarage, Murthy, Cheemala, Chaitanya, Kulkarni, Shankar, Bhagwat, Vinod D, Chaudhari, Majid, Sayyed, Vipul, Pachpute, Ramesh, Phadtare, Gopal, Gole, Samiron, Phukan, Brahmam, Sunkara, Charudatt, Samant, Manisha, Shingare, Aditya, Naik, Sneha, Trivedi, Ajit Kumar, Marisetti, Madhusudhan, Reddy, Milind, Gholve, Nilesh, Mahajan, Sudeep, Sabde, Vinod, Patil, Dipak, Modi, Maneesh, Mehta, Prashant, Nigade, Kaustubh, Tamane, Swati, Tota, Hemant, Goyal, Harish, Volam, Shashikant, Pawar, Prajakta, Ahirrao, Lal, Dinchhana, Sadanand, Mallurwar, Atul, Akarte, Anand, Bokare, Rupesh, Kanhere, Neetinkumar, Reddy, Sarita, Koul, Manoj, Dandekar, Minakshi, Singh, Peter R, Bernstein, Lakshmi, Narasimham, Mandar, Bhonde, Jayasagar, Gundu, Rajan, Goel, Sanjeev, Kulkarni, Sharad, Sharma, Rajender Kumar, Kamboj, Venkata P, Palle
Publikováno v:
Journal of medicinal chemistry. 63(23)
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9740bbdfcab4b764d76303bebfd167f6
https://pubmed.ncbi.nlm.nih.gov/33297683
https://pubmed.ncbi.nlm.nih.gov/33297683
Autor:
Vikrant Kumar, Bryn Hardwick, Saranya Giridharan, Sneha Sudhakar, Markus Muellner, Manjunath A. Hurakadli, Ashok R. Venkitaraman, Gayathri Sadasivam, T.K. Prasad, Neelagandan Kamariah, Grahame J. McKenzie, Alex T. Crooks, Subashini Mathivanan, Paul M. Watt, Miguel Coelho, Sneha Bairy, Nadia Milech, Chandan Mithra, Christopher J. Torrance, Amy Emery, Kavitha Bharatham
Publikováno v:
Cell Chemical Biology
Summary Genetic screening technologies to identify and validate macromolecular interactions (MMIs) essential for complex pathways remain an important unmet need for systems biology and therapeutics development. Here, we use a library of peptides from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82261f81e78bea18e12f385b6c100941
https://doi.org/10.1016/j.chembiol.2021.05.009
https://doi.org/10.1016/j.chembiol.2021.05.009
Autor:
Manjunath A. Hurakadli, Jayaprakash Periasamy, Vijay Potluri, Muralidhara Padigaru, Mamatha B. Nijaguna, Sanjana Boggaram, Gayathri Sadasivam, Lokavya Meenakshi Kurup, Ashok R. Venkitaraman, Dhruv Raina, Kavitha Bharatham, Subbarao Jasti, Aneesh Goyal, Vadiraj Kurdekar, Kavyashree Manjunath, Chetan Chintha
Publikováno v:
Cell Chemical Biology
Summary Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 C-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to small-molecule chemical inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effcfd978ee56cb42cfe6bb6ee159ab4
https://www.repository.cam.ac.uk/handle/1810/278984
https://www.repository.cam.ac.uk/handle/1810/278984
Autor:
Alain A. Camilleri, Markus A. Rüegg, Matthias Gesemann, Raffaella Willmann, Shuo Lin, Christian Fuhrer, Gayathri Sadasivam
Publikováno v:
BMC Neuroscience, Vol 8, Iss 1, p 46 (2007)
BMC Neuroscience
BMC Neuroscience
Background Development of neural networks requires that synapses are formed, eliminated and stabilized. At the neuromuscular junction (NMJ), agrin/MuSK signaling, by triggering downstream pathways, causes clustering and phosphorylation of postsynapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4dc925382fd214edb19866a9cfd0bc
http://www.biomedcentral.com/1471-2202/8/46
http://www.biomedcentral.com/1471-2202/8/46