Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Gayathri Nagalingam"'
Publikováno v:
Vaccines, Vol 12, Iss 1, p 50 (2024)
New control measures are urgently required to control tuberculosis (TB), as the current vaccine, Bacille Calmette–Guérin (BCG), has had a limited impact on disease spread. The identification of virulence mechanisms of Mycobacterium tuberculosis is
Externí odkaz:
https://doaj.org/article/3cd76c231a6145aab04f9b95c6efaa7b
Autor:
Claudio Counoupas, Rachel Pinto, Gayathri Nagalingam, Warwick J. Britton, Nikolai Petrovsky, James A. Triccas
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract There is an urgent need for the rational design of safe and effective vaccines to protect against chronic bacterial pathogens such as Mycobacterium tuberculosis. Advax™ is a novel adjuvant based on delta inulin microparticles that enhances
Externí odkaz:
https://doaj.org/article/00c5fecbb81548f3b3341ecbfce75e2a
Publikováno v:
International Journal of Infectious Diseases, Vol 56, Iss C, Pp 212-220 (2017)
Tuberculosis (TB) continues to be a significant cause of mortality and morbidity worldwide. An estimated 2 billion individuals are infected with Mycobacterium tuberculosis and annually there are approximately 10 million new cases of clinical TB and 1
Externí odkaz:
https://doaj.org/article/7af1d5792bf74c27a699bdaa9702c958
Autor:
Maria Galletta, Tristan A. Reekie, Gayathri Nagalingam, Amy L. Bottomley, Elizabeth J. Harry, Michael Kassiou, James A. Triccas
Publikováno v:
Antibiotics, Vol 9, Iss 8, p 523 (2020)
Methicillin-resistant Staphylococcus aureus (MRSA) has proven to be an imminent threat to public health, intensifying the need for novel therapeutics. Previous evidence suggests that cannabinoids harbour potent antibacterial activity. In this study,
Externí odkaz:
https://doaj.org/article/51ecf8ffd6f8413fb33f8e2961f83e90
Autor:
Franklin Afinjuomo, Thomas G. Barclay, Ankit Parikh, Rosa Chung, Yunmei Song, Gayathri Nagalingam, Jamie Triccas, Lixin Wang, Liang Liu, John D. Hayball, Nikolai Petrovsky, Sanjay Garg
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 555 (2019)
The use of particles for monocyte-mediated delivery could be a more efficient strategy and approach to achieve intracellular targeting and delivery of antitubercular drugs to host macrophages. In this study, the potential of inulin microparticles to
Externí odkaz:
https://doaj.org/article/ce1909c28b584b95aa4f503f02bca7da
Autor:
Antje Blumenthal, Gayathri Nagalingam, Jennifer H Huch, Lara Walker, Gilles J Guillemin, George A Smythe, Sabine Ehrt, Warwick J Britton, Bernadette M Saunders
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37314 (2012)
Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid. We found that
Externí odkaz:
https://doaj.org/article/210eb698ff0e4e4fbf34bddfd6c9bdbe
Autor:
Nicholas Smith, Diana Quan, Gayathri Nagalingam, James A. Triccas, Louis M. Rendina, Peter J. Rutledge
Publikováno v:
RSC Medicinal Chemistry. 13:1234-1238
Bis-substituted cyclam derivatives have recently emerged as a promising new class of antibacterial agents, displaying excellent activity against drug-resistant Mycobacterium tuberculosis (Mtb). Carborane pendants enhance this activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c7767d8058792594c16b14c043585d
https://doi.org/10.1039/d2md00150k
https://doi.org/10.1039/d2md00150k
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e08cda86f6791396aa219a030366f02
https://doi.org/10.1021/acs.jmedchem.1c01407
https://doi.org/10.1021/acs.jmedchem.1c01407
Autor:
Lisa Barbaro, Gayathri Nagalingam, James A. Triccas, Lendl Tan, Nicholas P. West, Daniel L. Priebbenow, Jonathan B. Baell
Publikováno v:
ChemMedChem. 18
To date, the clinical use of the anti-tubercular therapy bedaquiline has been somewhat limited due to safety concerns. Recent investigations determined that modification of the B- and C-ring units of bedaquiline delivered new diarylquinolines (for ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badb44da4195461af288f3ab13ded42a
https://doi.org/10.1002/cmdc.202200533
https://doi.org/10.1002/cmdc.202200533
Autor:
Gayathri Nagalingam, James A. Triccas, Nikolai Petrovsky, Warwick J. Britton, Claudio Counoupas, Rachel Pinto, Diana H. Quan
Publikováno v:
Vaccine. 39:1990-1996
The development of safe and effective adjuvants is a critical goal of vaccine development programs. In this report, we defined the immunostimulatory profile and protective effect against aerosol Mycobacterium tuberculosis infection of vaccine formula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19d3dd89d9bb12c443390230ead9609
https://doi.org/10.1016/j.vaccine.2021.02.041
https://doi.org/10.1016/j.vaccine.2021.02.041