Zobrazeno 1 - 10
of 1 289
pro vyhledávání: '"Gayathri N"'
Publikováno v:
Thalassemia Reports, Vol 13, Iss 1, Pp 51-69 (2023)
β-Thalassemia is an inherited hematological disorder that results from genetic changes in the β-globin gene, leading to the reduced or absent synthesis of β-globin. For several decades, the only curative treatment option for β-thalassemia has bee
Externí odkaz:
https://doaj.org/article/b7336f71dab64ae1b5742d3a971381a1
Autor:
Gowthami Mahendran, Oshadhi T. Jayasinghe, Dhanushika Thavakumaran, Gayan Mirihana Arachchilage, Gayathri N. Silva
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101276- (2022)
Precise regulation of gene expression is crucial for living cells to adapt for survival in diverse environmental conditions. Among the common cellular regulatory mechanisms, RNA-based regulators play a key role in all domains of life. Discovery of re
Externí odkaz:
https://doaj.org/article/82a88caa644e423c99331d6925d324a2
Autor:
Shansa Pranami E. Jayaweera, Sacheela Prasadi Wanigasinghe Kanakanamge, Dharshika Rajalingam, Gayathri N. Silva
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The proteasome is crucial for the degradation of intracellular proteins and plays an important role in mediating a number of cell survival and progression events by controlling the levels of key regulatory proteins such as cyclins and caspases in bot
Externí odkaz:
https://doaj.org/article/1539749653ac4a9da82be0000528dd75
Autor:
Lisa Sanderson, Marcelo da Silva, Gayathri N Sekhar, Rachel C Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cécile A Dreiss, Chris Lorenz, Mark Christie, Shanta J Persaud, Vanessa Yardley, Simon L Croft, Margarita Valero, Sarah A Thomas
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009276 (2021)
BackgroundHuman African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system st
Externí odkaz:
https://doaj.org/article/09b1e0c2a621449a9fa1562f25edd5f8
Autor:
Brogan Yarzabek, Anita J Zaitouna, Eli Olson, Gayathri N Silva, Jie Geng, Aviva Geretz, Rasmi Thomas, Sujatha Krishnakumar, Daniel S Ramon, Malini Raghavan
Publikováno v:
eLife, Vol 7 (2018)
The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers. Quality control mediated by peptide loading complex (PLC) components is expected to ens
Externí odkaz:
https://doaj.org/article/5d732d5c075a44ddaa544ca33c52941f
Autor:
Gayathri N Sekhar, Ana R Georgian, Lisa Sanderson, Gema Vizcay-Barrena, Rachel C Brown, Paula Muresan, Roland A Fleck, Sarah A Thomas
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173474 (2017)
Pentamidine is an effective trypanocidal drug used against stage 1 Human African Trypanosomiasis (HAT). At the blood-brain barrier (BBB), it accumulates inside the endothelial cells but has limited entry into the brain. This study examined transporte
Externí odkaz:
https://doaj.org/article/28e9a686342e4da29a0188fb884b4905
Publikováno v:
Annals of Indian Academy of Neurology, Vol 2, Iss 4, Pp 153-160 (1999)
Thirteen cases of vacuolar myopathy (6 males, 7 females), with age range of 4 months to 22 years and diagnosed over a period from 1986 to 1999, could be categorized into acid maltase deficiency (AMD) (n=6), carnitine deficiency (CD) (n=5), and mitoch
Externí odkaz:
https://doaj.org/article/fed9efb0d5bd4b748585a3405ec8aa25
Autor:
Gayathri N, Yasha T, Kanjalkar Makarand, Agarwal Santosh, Chandrashekar Sagar B, Santosh Vani, Shankar S
Publikováno v:
Annals of Indian Academy of Neurology, Vol 11, Iss 3, Pp 182-184 (2008)
Fabry′s disease, an X linked recessive disorder caused by the deficiency of a-galactosidase A (a-gal A), leads to progressive accumulation of glycosphingolipids. We report this rare disease in a 19-year-old boy who presented with angiokeratomas, pa
Externí odkaz:
https://doaj.org/article/91be0efc67274953b4ccacba5f605768
Publikováno v:
Annals of Indian Academy of Neurology, Vol 10, Iss 3, Pp 175-177 (2007)
Nemaline myopathies are a group of genetically determined (autosomal dominant/recessive) congenital myopathies characterized by the formation of nemaline rods within muscle fibers. Congenital, childhood, and adult forms with hypotonia, proximal muscl
Externí odkaz:
https://doaj.org/article/c8507560166a4bc2a60e8f8729dec4ae
Publikováno v:
In Computational and Theoretical Chemistry October 2024 1240