T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis

Autor: Emanuele de Rinaldis, Anna Chapman, Paola Di Meglio, Chiew Yee Chiew Yee Loh, Evan W. Newell, K. Grys, Consol Farrera, Hemawtee Sreeneebus, Karen Wei Weng Teng, Susanne Heck, Michael Wong, Catherine H. Smith, Rossella Melchiotti, Isabella Tosi, Jinmiao Chen, Gayathri K. Perera, Filipe Gracio, Nedyalko Petrov, Federica Villanova, Frank O. Nestle, Jonathan Barker

Publikováno v: Farrera, C, Melchiotti, R, Petrov, N, Wei Weng Teng, K, Wong, M T, Loh, C Y, Villanova, F, Tosi, I, Chen, J, Grys, K, Sreeneebus, H, Chapman, A, Perera, G K, Heck, S, Gracio, F, de Rinaldis, E, Barker, J N, Smith, C H, Nestle, F O, Newell, E W & Di Meglio, P 2020, ' T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis ', Journal of Allergy and Clinical Immunology, vol. 145, no. 3, pp. 1021-1025.e15 . https://doi.org/10.1016/j.jaci.2019.11.030

Deep-immunophenotyping of the circulatory T cell compartment using mass cytometry and unsupervised clustering analysis, identifies phenotypic and functional differences in patients with atopic dermatitis (AD) and psoriasis, highlighting the stronger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fc473b3514c1988610ba3c58251bd4
https://kclpure.kcl.ac.uk/en/publications/5c6cb9fb-1789-4f45-a68b-94fd103a8ea8

A rare cause of vulval swelling

Autor: Subothini Selvendran, Gayathri K. Perera, Rishika Sinha

Publikováno v: BMJ Case Rep

A 46-year-old woman presented to the emergency department with a 6-month history of gradually worsening vulval swelling, yellow discharge and excruciating pain on movement. She had previously attended her general practice, as well as her local urgent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ef41405105f98b5383ffd53ea4ec6c
https://pubmed.ncbi.nlm.nih.gov/31352400

Integrative biology approach identifies cytokine targeting strategies for psoriasis

Autor: Christian Hundhausen, Chrysanthi Ainali, Muddassar M. Mirza, Sophia Tsoka, Deepika Kassen, Gayathri K. Perera, Jonathan Barker, Andrew E. Williams, G. Barinaga, Andrej Alendar, Xiaoting Wang, Ekaterina Semenova, Robert Rodriguez, Frank O. Nestle, Mercedesz Balazs, Wenjun Ouyang

Publikováno v: Science translational medicine. 6(223)

Cytokines are critical checkpoints of inflammation. The treatment of human autoimmune disease has been revolutionized by targeting inflammatory cytokines as key drivers of disease pathogenesis. Despite this, there exist numerous pitfalls when transla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dceb2be7676d73afe8f7de67e4ba710b
https://pubmed.ncbi.nlm.nih.gov/24523322

Transcriptome classification reveals molecular subtypes in psoriasis

Autor: Chrysanthi Ainali, A. Williams, Sophia Tsoka, Frank O. Nestle, Johann E. Gudjonsson, Gayathri K. Perera, Christos A. Ouzounis, Najl V. Valeyev

Publikováno v: BMC Genomics, Vol 13, Iss 1, p 472 (2012)
BMC Genomics
BMC Genomics; Vol 13

Background Psoriasis is an immune-mediated disease characterised by chronically elevated pro-inflammatory cytokine levels, leading to aberrant keratinocyte proliferation and differentiation. Although certain clinical phenotypes, such as plaque psoria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a28069e8d773b65b614bb517335c9
http://www.biomedcentral.com/1471-2164/13/472

Identification of a novel pro-inflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis

Autor: Christian Hundhausen, Ute Laggner, Adrian Hayday, Catherine H. Smith, Niwa Ali, Brian J. Nickoloff, Katie E. Lacy, Gayathri K. Perera, Frank O. Nestle, Paola Di Meglio

γδ T cells mediate rapid tissue responses in murine skin and participate in cutaneous immune regulation including protection against cancer. The role of human γδ cells in cutaneous homeostasis and pathology is characterized poorly. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1612ef9def2b5015a6dd0335c3e81cfa
https://europepmc.org/articles/PMC3187621/