Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Gayan S"'
Autor:
Michael J Currie, James S Davies, Mariafrancesca Scalise, Ashutosh Gulati, Joshua D Wright, Michael C Newton-Vesty, Gayan S Abeysekera, Ramaswamy Subramanian, Weixiao Y Wahlgren, Rosmarie Friemann, Jane R Allison, Peter D Mace, Michael DW Griffin, Borries Demeler, Soichi Wakatsuki, David Drew, Cesare Indiveri, Renwick CJ Dobson, Rachel A North
Publikováno v:
eLife, Vol 12 (2024)
Tripartite ATP-independent periplasmic (TRAP) transporters are secondary-active transporters that receive their substrates via a soluble-binding protein to move bioorganic acids across bacterial or archaeal cell membranes. Recent cryo-electron micros
Externí odkaz:
https://doaj.org/article/59de71f8bf864a14be2120a060302bca
Autor:
James S. Davies, Michael J. Currie, Rachel A. North, Mariafrancesca Scalise, Joshua D. Wright, Jack M. Copping, Daniela M. Remus, Ashutosh Gulati, Dustin R. Morado, Sam A. Jamieson, Michael C. Newton-Vesty, Gayan S. Abeysekera, Subramanian Ramaswamy, Rosmarie Friemann, Soichi Wakatsuki, Jane R. Allison, Cesare Indiveri, David Drew, Peter D. Mace, Renwick C. J. Dobson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Bacteria and archaea use tripartite ATP-independent periplasmic (TRAP) transporters to import essential nutrients. Davies et al. report a high resolution structure of a TRAP and show that it uses an ‘elevator-with-an operator’ mechanism.
Externí odkaz:
https://doaj.org/article/a1b3692949d14006b916bdaba4de7228
Autor:
Shirli Tay, Gayan S. De Silva, Connor M. Engel, Nikolai Harroun, Amanda S. Penrose, Kshitij A. Desai, Yan Yan, Clay F. Semenkovich, Mohamed A. Zayed
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract There are currently no serum-based evaluations that can corroborate the severity of peripheral artery disease (PAD). In this cross-sectional study, we assessed the prevalence of elevated serum fatty acid synthase (cFAS) in patients with chro
Externí odkaz:
https://doaj.org/article/9a974cab434647dba598d68943591583
Autor:
Gayan S. Abeysekera, Michael J. Love, Sarah H. Manners, Craig Billington, Renwick C. J. Dobson
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Holins and spanins are bacteriophage-encoded membrane proteins that control bacterial cell lysis in the final stage of the bacteriophage reproductive cycle. Due to their efficient mechanisms for lethal membrane disruption, these proteins are gaining
Externí odkaz:
https://doaj.org/article/3f0bb5580c8b49c7be4ff093b977739d
Autor:
Michael J. Love, David Coombes, Sarah H. Manners, Gayan S. Abeysekera, Craig Billington, Renwick C. J. Dobson
Publikováno v:
Viruses, Vol 13, Iss 6, p 1101 (2021)
Bacteriophage-encoded endolysins have been identified as antibacterial candidates. However, the development of endolysins as mainstream antibacterial agents first requires a comprehensive biochemical understanding. This study defines the atomic struc
Externí odkaz:
https://doaj.org/article/6e0dd06e219d4645aeb306a9a044a238
Autor:
Shirli Tay, Amanda Penrose, Gayan S. De Silva, Yan Yan, Clay F. Semenkovich, Mohamed A. Zayed
Publikováno v:
JVS - Vascular Science, Vol 1, Iss , Pp 249-250 (2020)
Externí odkaz:
https://doaj.org/article/bfa66de806ff48e19d7d0bddcf291419
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196404 (2018)
The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5'-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid. Kynurenic acid is implicated in human
Externí odkaz:
https://doaj.org/article/b0d5c3e3183f4e44858ae8b1bc46ecb0
Autor:
Gayan S. Bamunuarachchi, Wanigasekara D. Ratnasooriya, Sirimal Premakumara, Preethi V. Udagama
Publikováno v:
Journal of Vector Borne Diseases, Vol 51, Iss 4, Pp 286-293 (2014)
Background & objectives: Artemisinin isolated from Artemisia annua is the most potent antimalarial against chloroquine resistant Plasmodium falciparum malaria. We previously reported that the ethanolic leaf extract of Artemisia vulgaris, an invasive
Externí odkaz:
https://doaj.org/article/8a46ac163c10455e97876adbaae549eb
Autor:
Gayan S. Bamunuarachchi, Wanigasekara D. Ratnasooriya, Sirimal Premakumara, Preethi V. Udagama
Publikováno v:
Journal of Vector Borne Diseases, Vol 50, Iss 4, Pp 278-284 (2013)
Background & objectives: Artemisinin isolated from Artemisia annua is the most potent antimalarial drug against chloroquine-resistant Plasmodium falciparum malaria. Artemisia vulgaris, an invasive weed, is the only Artemisia species available in Sri
Externí odkaz:
https://doaj.org/article/05b065fd34dc47aa9d20b24e5fca5dce
Publikováno v:
Molecules, Vol 21, Iss 7, p 856 (2016)
Abnormal levels of kynurenic acid (KYNA) in the human brain are believed to be connected to several central nervous system (CNS) diseases, therefore compounds which affect the production of this crucial metabolite are of interest in CNS drug developm
Externí odkaz:
https://doaj.org/article/38f51e7a20c7405fa8f0fd024c3838de