Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gayan Heruka de Zoysa"'
Autor:
Aparajita Chakraborty, Elisey Kobzev, Jonathan Chan, Gayan Heruka de Zoysa, Vijayalekshmi Sarojini, Thomas J. Piggot, Jane R Allison
Publikováno v:
ACS Omega, Vol 6, Iss 1, Pp 388-400 (2020)
Externí odkaz:
https://doaj.org/article/c106c5ee85b44e869ee9f7ab060105f2
Publikováno v:
Molecules, Vol 25, Iss 24, p 5945 (2020)
Novel antibiotic treatments are in increasing demand to tackle life-threatening infections from bacterial pathogens. In this study, we report the use of a potent battacin lipopeptide as an antimicrobial gel to inhibit planktonic and mature biofilms o
Externí odkaz:
https://doaj.org/article/faa08dc490fa4ca3a9a7c239789503be
Autor:
Gayan Heruka De Zoysa, Zimei Wu, Lisa I. Pilkington, Manju Kanamala, Jóhannes Reynisson, Krunal Patel, Vijayalekshmi Sarojini, David Barker, Kamal Patel
Publikováno v:
Journal of Medicinal Chemistry. 63:334-348
Cell-penetrating peptide conjugated peptide aldehydes Tat-A and Tat-B showed low micromolar anticancer and antifungal activities and synergistic action in combination with cisplatin and amphotericin B against cancer and fungal cells, respectively. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecabef97333e9b6a7c03dd8bf89dcffd
https://doi.org/10.1021/acs.jmedchem.9b01694
https://doi.org/10.1021/acs.jmedchem.9b01694
Autor:
Ilva D. Rupenthal, Gamith L. Kumarasinghe, Hans Vellara, Darina Khun, Vijayalekshmi Sarojini, Stephen Lee, Gayan Heruka De Zoysa, Sachin S. Thakur
Publikováno v:
Clinical and Experimental Optometry. 102:583-589
Povidone-iodine is used as a cost-effective broad-spectrum antiseptic in the prophylaxis and treatment of certain ocular infections. In this study, the stability, ophthalmic irritation potential and antibacterial efficacy of an extemporaneous povidon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1f7f30012055d05609ea1df4019d2d
https://doi.org/10.1111/cxo.12899
https://doi.org/10.1111/cxo.12899
Autor:
Timothy M. Ryan, Vijayalekshmi Sarojini, Jitendra P. Mata, Rayomand Shahlori, Praveen G. Vadakkedath, Duncan J. McGillivray, Shinji Kihara, Gayan Heruka De Zoysa
Publikováno v:
Soft Matter. 15:7501-7508
In recent years, lipopeptides have received attention for their enhanced antimicrobial activity, especially against multi-drug resistant (MDR) pathogens. We have previously reported that the bacterial soil extracted, novel cyclic lipopeptide, battaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12c8c06eef7cde5553966c45f894f5c
https://doi.org/10.1039/c9sm00932a
https://doi.org/10.1039/c9sm00932a
Autor:
Jonathan W. Astin, Muhammad Hanif, Stephen M. F. Jamieson, Shahida Parveen, Euphemia Leung, Tasha R. Steel, Christian G. Hartinger, Gayan Heruka De Zoysa, Annie Yang, Kelvin K. H. Tong, Sanam Movassaghi, David M. Goodman, Vijayalekshmi Sarojini, Tilo Söhnel
Publikováno v:
Chemical Communications. 55:12016-12019
Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47201a98acb906af4753cd2959e512d
https://doi.org/10.1039/c9cc03822a
https://doi.org/10.1039/c9cc03822a
Publikováno v:
European Journal of Medicinal Chemistry. 146:344-353
Novel antifungal agents are required against pathogenic fungi such as Candida albicans. We report the anticandidal activity of battacin lipopeptide antibiotics with previously unexplored antifungal activity. From amongst sixteen battacin lipopeptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bf94462b4da27af00e0de2335bc3d1
https://doi.org/10.1016/j.ejmech.2018.01.023
https://doi.org/10.1016/j.ejmech.2018.01.023
Autor:
Jun Lu, Gayan Heruka De Zoysa, Vijayalekshmi Sarojini, Kelvin Wang, Céline Valéry, Hugh D. Glossop, Yacine Hemar, Priscila Cardoso
Publikováno v:
Biomacromolecules. 20(7)
Peptides can serve as versatile therapeutics with a highly modular structure and tunable biophysical properties. In particular, the efficacy of peptide antibiotics against drug-resistant pathogens is of great promise, as few new classes of antibiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d3878e14efc170d00038cf32c99b99
https://pubmed.ncbi.nlm.nih.gov/31145611
https://pubmed.ncbi.nlm.nih.gov/31145611
Autor:
David Barker, Hugh D. Glossop, Vijayalekshmi Sarojini, Gayan Heruka De Zoysa, Lisa I. Pilkington
Publikováno v:
Journal of Fluorine Chemistry. 241:109685
As a crucial structural element in many antimicrobial lipopeptides, phenylalanine poses a potential, but sensitive, point of modification in the pursuit of enhancing the antimicrobial efficacy of peptide antibiotics. We report the synthesis and appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07533ca0541722c534673dd1d956846e
https://doi.org/10.1016/j.jfluchem.2020.109685
https://doi.org/10.1016/j.jfluchem.2020.109685
Autor:
Michelle van Rensburg, Jóhannes Reynisson, Mirae Song, Vijayalekshmi Sarojini, Homayon J. Arabshahi, William A. Denny, Gayan Heruka De Zoysa, Lisa I. Pilkington, David Barker, Chae Yeon Jeon, Euphemia Leung
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:1142-1154
Seventy nine derivatives of thieno[2,3-b]quinolines, tetrahydrothieno[2,3-b]quinoline, dihydrocyclopenta[b]thieno[3,2-e]pyridine, cyclohepta[b]thieno[3,2-e]pyridine and hexahydrocycloocta[b]thieno[3,2-e]pyridine were either synthesized or obtained co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9e0906f35eef0a7c7d50bb7c09f46
https://doi.org/10.1016/j.bmc.2016.01.047
https://doi.org/10.1016/j.bmc.2016.01.047