Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: Results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study

Autor: Chanchlani, N, Lin, S, Auth, MK, Lee, CL, Robbins, H, Looi, S, Murugesan, SV, Riley, T, Preston, C, Stephenson, S, Cardozo, W, Sonwalkar, SA, Allah-Ditta, M, Mansfield, L, Durai, D, Baker, M, London, I, London, E, Gupta, S, Di Mambro, A, Murphy, A, Gaynor, E, Jones, KDJ, Claridge, A, Sebastian, S, Ramachandran, S, Selinger, CP, Borg-Bartolo, SP, Knight, P, Sprakes, MB, Burton, J, Kane, P, Lupton, S, Fletcher, A, Gaya, DR, Colbert, R, Seenan, JP, MacDonald, J, Lynch, L, McLachlan, I, Shields, S, Hansen, R, Gervais, L, Jere, M, Akhtar, M, Black, K, Henderson, P, Russell, RK, Lees, CW, Derikx, LAAP, Lockett, M, Betteridge, F, De Silva, A, Hussenbux, A, Beckly, J, Bendall, O, Hart, JW, Thomas, A, Hamilton, B, Gordon, C, Chee, D, McDonald, TJ, Nice, R, Parkinson, M, Gardner-Thorpe, H, Butterworth, JR, Javed, A, Al-Shakhshir, S, Yadagiri, R, Maher, S, Pollok, RCG, Ng, T, Appiahene, P, Donovan, F, Lok, J, Chandy, R, Jagdish, R, Baig, D, Mahmood, Z, Marsh, L, Moss, A, Abdulgader, A, Kitchin, A, Walker, GJ, George, B, Lim, Y-H, Gulliver, J, Bloom, S, Theaker, H, Carlson, S, Cummings, JRF, Livingstone, R, Beale, A, Carter, JO, Bell, A, Coulter, A, Snook, J, Stone, H, Kennedy, NA, Goodhand, JR, Ahmad, T, IMSAT study investigators

BACKGROUND: Anti-drug antibodies are associated with treatment failure to anti-TNF agents in patients with inflammatory bowel disease (IBD). AIM: To assess whether immunogenicity to a patient's first anti-TNF agent would be associated with immunogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::39d735bb09a4a7716e305b56c8e08c0b

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

Autor: Walker, GJ, Harrison, JW, Heap, GA, Voskuil, MD, Andersen, V, Anderson, CA, Ananthakrishnan, AN, Barrett, JC, Beaugerie, L, Bewshea, CM, Cole, AT, Cummings, FR, Daly, MJ, Ellul, P, Fedorak, RN, Festen, EAM, Florin, TH, Gaya, DR, Halfvarson, J, Hart, AL, Heerasing, NM, Hendy, P, Irving, PM, Jones, SE, Koskela, J, Lindsay, JO, Mansfield, JC, McGovern, D, Parkes, M, Pollok, RCG, Ramakrishnan, S, Rampton, DS, Rivas, MA, Russell, RK, Schultz, M, Sebastian, S, Seksik, P, Singh, A, So, K, Sokol, H, Subramaniam, K, Todd, A, Annese, V, Weersma, RK, Xavier, R, Ward, R, Weedon, MN, Goodhand, JR, Kennedy, NA, Ahmad, T, Holden, AL, Andrews, J, Auth, M, Babu, S, Bampton, P, Banim, P, Barnes, T, Basude, D, Beckly, J, Bell, A, Bell, S, Bhandari, P, Bloom, S, Border, D, Bredin, F, Brookes, MJ, Brown, M, Calvert, C, Campbell, D, Chanchlani, N, Chaudhary, B, Chaudhary, R, Chung-Faye, G, Colleypriest, B, Connor, S, Cooney, R, Cooper, S, Creed, TJ, Croft, N, Cullen, S, D'Amato, M, Dalal, H, Daneshmend, TK, Das, D, Delaney, M, Desilva, S, Dhar, A, Dharmasiri, S, Direkze, N, Dunckley, P, Elphick, D, Everett, SM, Feeney, M, Fell, J, Foley, S, Franke, A, Gavin, D, Gee, I, Ghosh, D, Goldsmith, C, Gorard, D, Gordon, JN, Gore, S, Green, J, Grimes, D, Hamill, G, Harbord, M, Hart, J, Hawkey, C, Iqbal, T, Ireland, A, Johnson, M, Jones, C, Kanegasundaram, S, Karban, A, Katsanos, KH, Kiparissi, F, Kirkham, S, Lal, S, Langlands, S, Lawrance, IC, Lees, CW, Lev-Tzion, R, Levison, S, Lewis, SJ, Li, A, Limdi, J, Lin, S, Lobo, A, Lockett, M, Loehry, J, MacDonald, C, MacFaul, G, Mahmood, T, Mann, S, Mawdsley, J, Mazhar, Z, McGovern, JF, McNair, A, Modi, A, Monahan, K, Moran, A, Morris, M-A, Mortimore, M, Mowat, C, Muhammed, R, Murray, CDR, Olivier, H, Orchard, TR, Panter, S, Patel, V, Phillips, R, Prasad, N, Preston, C, Radford-Smith, G, Rajasekhar, P, Roy, D, Saich, R, Satsangi, J, Schreiber, S, Sen, S, Shah, N, Shenderay, R, Shenoy, A, Shutt, J, Silverberg, M, Simmons, A, Simmons, J, Singh, S, Smith, M, Snook, JA, Sonwalker, S, Stevens, CR, Sturniolo, G, Subramanian, S, Thomas, A, Tighe, M, Torrente, F, Tremelling, M, Tsianos, E, Vani, D, Walsh, A, Watermeyer, G, Watts, D, Watts, G, Weaver, S, Wesley, E, Willmott, A, Yearsley, K, Zambar, V, Zeissig, S

Publikováno v: JAMA, 321(8), 773-785. AMER MEDICAL ASSOC

Funding Information: reported serving as a consultant for AbbVie UK; receiving honoraria from Falk and AbbVie UK; receiving grants from Crohn’s & Colitis UK and Tillott’s Pharmaceuticals; having a fellowship from the UK National Institute for Hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8d78d1552e80b56aa35df97ff0b107
http://hdl.handle.net/10138/308428

Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

Autor: Mowat, C, Arnott, I, Cahill, A, Smith, M, Ahmad, T, Subramanian, S, Travis, S, Morris, J, Hamlin, J, Dhar, A, Nwokolo, C, Edwards, C, Creed, T, Bloom, S, Yousif, M, Thomas, L, Campbell, S, Lewis, SJ, Sebastian, S, Sen, S, Lal, S, Hawkey, C, Murray, C, Cummings, F, Goh, J, Lindsay, JO, Arebi, N, Potts, L, McKinley, AJ, Thomson, JM, Todd, JA, Collie, M, Dunlop, MG, Mowat, A, Gaya, DR, Winter, J, Naismith, GD, Ennis, H, Keerie, C, Lewis, S, Prescott, RJ, Kennedy, NA, Satsangi, J, TOPPIC Study Group

BACKGROUND: Up to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay postoperative clinical recurr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ac6e2ebe6d21749e898e455b88bdcb3e
https://ora.ox.ac.uk/objects/uuid:f1a6c016-1447-48fa-bfbe-c6fd8342b2a9

New genes in inflammatory bowel disease: lessons for complex diseases?

Autor: Gaya DR (AUTHOR), Russell RK (AUTHOR), Nimmo ER (AUTHOR), Satsangi J (AUTHOR)

Publikováno v: Lancet. 4/15/2006, Vol. 367 Issue 9518, p1271-1284. 14p.

Crohn's Disease in Childhood: The Case for Enteral Nutrition

Autor: Gaya Dr

Publikováno v: Scottish Medical Journal. 44:68-70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed80e8dded4d99dbab0ad8b738bda28b
https://doi.org/10.1177/003693309904400302