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Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: "A Spoonful of Sugar Helps the Medicine Go Down".

Autor: Pinyon JL; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia.; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia., von Jonquieres G; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Crawford EN; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Abed AA; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Power JM; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Klugmann M; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Browne CJ; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia.; Medical Sciences, School of Science, Western Sydney University, Sydney, NSW, 2560, Australia., Housley DM; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Wise AK; Bionics Institute, 384-388 Albert Street, East Melbourne, VIC, 3002, Australia.; Medical Bionics, Department of Otolaryngology, University of Melbourne, Melbourne, VIC, 3002, Australia., Fallon JB; Bionics Institute, 384-388 Albert Street, East Melbourne, VIC, 3002, Australia.; Medical Bionics, Department of Otolaryngology, University of Melbourne, Melbourne, VIC, 3002, Australia., Shepherd RK; Bionics Institute, 384-388 Albert Street, East Melbourne, VIC, 3002, Australia.; Medical Bionics, Department of Otolaryngology, University of Melbourne, Melbourne, VIC, 3002, Australia., Lin JY; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS, 7001, Australia., McMahon C; Faculty of Medicine and Health Sciences, The Hearing Hub, Macquarie University, Sydney, 2109, Australia., McAlpine D; Faculty of Medicine and Health Sciences, The Hearing Hub, Macquarie University, Sydney, 2109, Australia., Birman CS; Faculty of Medicine and Health Sciences, The Hearing Hub, Macquarie University, Sydney, 2109, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia.; Department of Otolaryngology, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia.; NextSense, Royal Institute of Deaf and Blind Children, Gladesville, NSW, 2111, Australia., Lai W; NextSense, Royal Institute of Deaf and Blind Children, Gladesville, NSW, 2111, Australia., Enke YL; Cochlear Limited, Macquarie University, University Avenue, Macquarie Park, NSW, 2109, Australia., Carter PM; Cochlear Limited, Macquarie University, University Avenue, Macquarie Park, NSW, 2109, Australia., Patrick JF; Cochlear Limited, Macquarie University, University Avenue, Macquarie Park, NSW, 2109, Australia., Gay RD; Cochlear Limited, Macquarie University, University Avenue, Macquarie Park, NSW, 2109, Australia., Marie C; CNRS, Inserm, UTCBS, Université Paris Cité, Paris, F-75006, France.; Chimie ParisTech, Université PSL, Paris, 75005, France., Scherman D; CNRS, Inserm, UTCBS, Université Paris Cité, Paris, F-75006, France.; Fondation Maladies Rares, 96 rue Didot, Paris, 75014, France., Lovell NH; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia., Housley GD; Translational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, Graduate School of Biomedical Engineering, Tyree Institute for Health Engineering (IHealthE), UNSW, Sydney, NSW, 2052, Australia.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug; Vol. 11 (30), pp. e2401392. Date of Electronic Publication: 2024 Jun 14.

Anti-TNFα domain antibody construct CEP-37247: Full antibody functionality at half the size.

Autor: Gay RD; Cephalon Australia Pty Ltd, Macquarie Park, New South Wales, Australia. rgay@cephalon.com, Clarke AW, Elgundi Z, Domagala T, Simpson RJ, Le NB, Doyle AG, Jennings PA

Publikováno v: MAbs [MAbs] 2010 Nov-Dec; Vol. 2 (6), pp. 625-38. Date of Electronic Publication: 2010 Nov 01.