Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Gawthrop, Peter"'
Autor:
Gawthrop, Peter J., Pan, Michael
Interactions between biomolecules, electrons and protons are essential to many fundamental processes sustaining life. It is therefore of interest to build mathematical models of these bioelectrical processes not only to enhance understanding but also
Externí odkaz:
http://arxiv.org/abs/2009.02217
Autor:
Gawthrop, Peter J.
Whole-cell modelling is constrained by the laws of nature in general and the laws of thermodynamics in particular. This paper shows how one prolific source of information, stoichiometric models of biomolecular systems, can be integrated with thermody
Externí odkaz:
http://arxiv.org/abs/2007.15917
Autor:
Gawthrop, Peter J
Publikováno v:
IEEE Transactions on NanoBioscience, 2021
Energy-based modelling brings engineering insight to the understanding of biomolecular systems. It is shown how well-established control engineering concepts, such as loop-gain, arise from energy feedback loops and are therefore amenable to control e
Externí odkaz:
http://arxiv.org/abs/2007.14762
BondGraphTools is a Python library for scripted modelling of complex multi-physics systems. In contrast to existing modelling solutions, BondGraphTools is based upon the well established bond graph methodology, provides a programming interface for sy
Externí odkaz:
http://arxiv.org/abs/1906.10799
Publikováno v:
Journal of Theoretical Biology, Vol. 493, May 2020
Systems biology and whole-cell modelling are demanding increasingly comprehensive mathematical models of cellular biochemistry. These models require the development of simplified models of specific processes which capture essential biophysical featur
Externí odkaz:
http://arxiv.org/abs/1905.12958
Autor:
Gawthrop, Peter J., Crampin, Edmund J.
Publikováno v:
IEEE Transactions on NanoBioscience ( Volume: 17 , Issue: 4 , Oct. 2018 )
The Bond Graph approach and the Chemical Reaction Network approach to modelling biomolecular systems developed independently. This paper brings together the two approaches by providing a bond graph interpretation of the chemical reaction network conc
Externí odkaz:
http://arxiv.org/abs/1809.00449
Publikováno v:
Journal of Theoretical Biology, Available online 28 September 2018
Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell membranes. Like all physical systems, the behaviour of membrane transporters is constrained by the laws of thermodynamics.
Externí odkaz:
http://arxiv.org/abs/1806.04341
Autor:
Gawthrop, Peter J., Crampin, Edmund J.
Efficient energy transduction is one driver of evolution; and thus understanding biomolecular energy transduction is crucial to understanding living organisms. As an energy-orientated modelling methodology, bond graphs provide a useful approach to de
Externí odkaz:
http://arxiv.org/abs/1803.09231
Publikováno v:
Proc. R. Soc. A 2018 474 20180106
Mathematical models of cardiac action potentials have become increasingly important in the study of heart disease and pharmacology, but concerns linger over their robustness during long periods of simulation, in particular due to issues such as model
Externí odkaz:
http://arxiv.org/abs/1802.04548
