Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Gavril W, Pasternak"'
Autor:
Andrew C. Kruegel, Rajendra Uprety, Steven G. Grinnell, Cory Langreck, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M. Gassaway, John E. Pintar, Gavril W. Pasternak, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 992-1001 (2019)
Externí odkaz:
https://doaj.org/article/971cb77fff204fd6a76409176ec31011
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006689 (2019)
The differential modulation of agonist and antagonist binding to opioid receptors (ORs) by sodium (Na+) has been known for decades. To shed light on the molecular determinants, thermodynamics, and kinetics of Na+ translocation through the μ-OR (MOR)
Externí odkaz:
https://doaj.org/article/44ff0c4c73524bdca52bb6fed6851377
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Autor:
Gavril W. Pasternak, Rahul Jilakara, Ying Xian Pan, Rajendra Uprety, Amanda Hunkele, Kevin Appourchaux, Tao Che, Amal El Daibani, Shainnel O. Eans, Jay P. McLaughlin, Lisa Thammavong, Soumen Chakraborty, Susruta Majumdar, Valerie Le Rouzic, Nitin Nuthikattu
Publikováno v:
ACS Chem Neurosci
Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 alkaloids in kratom; however, investigations to date have focused around mit
Autor:
Ling Pan, David A Pasternak, Jin Xu, Mingming Xu, Zhigang Lu, Gavril W Pasternak, Ying-Xian Pan
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174694 (2017)
The sigma1 receptor acts as a chaperone at the endoplasmic reticulum, associates with multiple proteins in various cellular systems, and involves in a number of diseases, such as addiction, pain, cancer and psychiatric disorders. The sigma1 receptor
Externí odkaz:
https://doaj.org/article/5597b003b44a4b6ab4926c4829154535
Autor:
Ying-Xian Pan, Andras Varadi, Gavril W. Pasternak, Joan J. Subrath, Amanda Hunkele, Susruta Majumdar, Rajendra Uprety, Steven G. Grinnell
Publikováno v:
Cell Mol Neurobiol
Mu opioid receptors (MOR-1) mediate the biological actions of clinically used opioids such as morphine, oxycodone, and fentanyl. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, generating multiple splice variants. One ty
Autor:
Anna M. Gutridge, Gavril W. Pasternak, Kendall L. Mores, Rajendra Uprety, Robert J. Cassell, Mee Jung Ko, Susruta Majumdar, Meridith T. Robins, Richard M. van Rijn
Publikováno v:
British Journal of Pharmacology
Background and Purpose Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self‐medication of chronic pain and to reduce illicit and prescript
Autor:
Roger S. Wilson, Takeshi Irie, Gregory W. Fischer, Ying-Xian Pan, Valerie Le Rouzic, Rebecca Shum, Amanda Hunkele, Gavril W. Pasternak, Jin Xu, Ioanna Deni
Publikováno v:
Molecular Pharmacology. 96:247-258
Circular RNAs (circRNAs) are a distinct category of single-stranded, covalently closed RNAs formed by backsplicing. The functions of circRNAs are incompletely known and are under active investigation. Here, we report that in addition to traditional l
Autor:
John E. Pintar, Andrew C. Kruegel, Gavril W. Pasternak, Jonathan A. Javitch, Steven G. Grinnell, Madalee M. Gassaway, Dalibor Sames, Rajendra Uprety, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Susruta Majumdar, Michael Ansonoff, Cory Langreck
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 992-1001 (2019)
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United