Výsledky vyhledávání - "Gavriel F. Roda"

Direct and indirect activation of the adenosine triphosphate–sensitive potassium channel to induce spinal cord ischemic metabolic tolerance

Autor: Xianzhong Meng, Joseph C. Cleveland, Christian V. Ghincea, Gavriel F. Roda, Linling Cheng, Michael J. Weyant, David A. Fullerton, T. Brett Reece, Yuki Ikeno, Muhammad Aftab

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 165:e90-e99

OBJECTIVES The mitochondrial adenosine triphosphate-sensitive potassium channel is central to pharmacologically induced tolerance to spinal cord injury. We hypothesized that both direct and nitric oxide-dependent indirect activation of the adenosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90e7ffbb0c70c7a7d324c4ee30b573e
https://doi.org/10.1016/j.jtcvs.2021.08.085

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Optimizing Nicorandil for Spinal Cord Protection in a Murine Model of Complex Aortic Intervention

Autor: Muhammad Aftab, Joseph C. Cleveland, David A. Fullerton, Michael J. Weyant, Gavriel F. Roda, Yuki Ikeno, T.B. Reece, Linling Cheng, Xianzhong Meng, Christian V. Ghincea

Publikováno v: Seminars in Thoracic and Cardiovascular Surgery. 34:28-38

There are currently no clinically utilized pharmacological agents for the induction of metabolic tolerance to spinal cord ischemia-reperfusion injury in the setting of complex aortic intervention. Nicorandil, a nitric oxide donor and ATP-sensitive po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f616c4a555da10b56a8709f24f2a1c
https://doi.org/10.1053/j.semtcvs.2021.01.003

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Abstract 13107: Nitroglycerin Pretreatment Induces Metabolic Tolerance to Spinal Cord Ischemia-reperfusion Injury Through Nitric Oxide-mediated Mitochondrial Katp Channel Activation

Autor: Joseph C. Cleveland, Gavriel F. Roda, David A. Fullerton, Michael J. Weyant, Xianzhong Meng, Christian V. Ghincea, T.B. Reece, Yuki Ikeno, Muhammad Aftab, Linling Cheng

Publikováno v: Circulation. 142

Introduction: Pharmacologic induction of metabolic tolerance to spinal cord ischemia-reperfusion injury (SCI) after thoracoabdominal aortic intervention is not well established. We previously demonstrated that nicorandil pretreatment preserved motor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59c53526a11b1639dbf40c8f60e8e79f
https://doi.org/10.1161/circ.142.suppl_3.13107

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Reactive Oxygen Species Mediate Nicorandil-induced Metabolic Tolerance to Spinal Cord Injury

Autor: Muhammad Aftab, Xianzhong Meng, Christian V. Ghincea, Joseph C. Cleveland, David A. Fullerton, T. Brett Reece, Yuki Ikeno, Michael J. Weyant, Linling Cheng, Gavriel F. Roda

Publikováno v: The Annals of thoracic surgery. 112(1)

Spinal cord injury remains a devastating complication of thoracoabdominal aortic surgery. We previously demonstrated that pretreatment with nicorandil preserved motor function in a murine spinal cord injury model through mitochondrial adenosine triph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d894d18097538354c22b105a9787d98
https://pubmed.ncbi.nlm.nih.gov/33902895

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Utility of neuromonitoring in hypothermic circulatory arrest cases for early detection of stroke: Listening through the noise

Autor: Yuki Ikeno, Mohamed Eldeiry, T. Brett Reece, Gavriel F. Roda, Kelly Aunkst, David A. Fullerton, Christian V. Ghincea, Michael Bronsert, Muhammad Aftab, Devon Anderson

Publikováno v: The Journal of thoracic and cardiovascular surgery. 162(4)

Objective Stroke remains a potentially devastating complication of aortic arch intervention. The value of neurophysiologic intraoperative monitoring (NIOM) in the early identification of stroke is unclear. We evaluated the utility of NIOM for early s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb002be71b9c28e58417c2396a3a92
https://pubmed.ncbi.nlm.nih.gov/32279966

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Predictors of Acute Kidney Injury Following Aortic Arch Surgery

Autor: Jay D. Pal, David A. Fullerton, T. Brett Reece, Muhammad Aftab, Joseph C. Cleveland, Christian V. Ghincea, Mohamed Eldeiry, Michael Jarrett, Michael Bronsert, Gavriel F. Roda

Publikováno v: The Journal of surgical research. 242

Acute kidney injury (AKI) following open aortic arch surgery is a frequent complication associated with increased morbidity and mortality. The primary purpose of this study was to evaluate risk factors for postoperative AKI in patients who underwent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf3277e0bb02302608612fdf28b7a58
https://pubmed.ncbi.nlm.nih.gov/31063910

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Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway

Autor: T. Brett Reece, Michael J. Weyant, Katsuhiro Yamanaka, Muhammad Aftab, Mohamed Eldeiry, Gavriel F. Roda, Xianzhong Meng, Joseph C. Cleveland, David A. Fullerton, Thomas J. Ryan

Publikováno v: The Annals of thoracic surgery. 107(3)

Background Delayed paraplegia remains a feared complication of thoracoabdominal aortic intervention. Pharmacologic preconditioning with diazoxide (DZ), an adenosine 5′-triphosphate–sensitive potassium channel opener, results in neuroprotection ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5648c8b677b60ceb0c0befe7fa6094
https://pubmed.ncbi.nlm.nih.gov/30395862

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