Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Gavin Tjin"'
Publikováno v:
Blood Science, Vol 6, Iss 4, p e00202 (2024)
Externí odkaz:
https://doaj.org/article/f667ab4fa84b40d4a2e694e14ad86fdd
Autor:
Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1301-1312 (2017)
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with few effective therapeutic options. Structural remodelling of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enz
Externí odkaz:
https://doaj.org/article/fff12f96f4b74203ac5893fb11c8fec6
Autor:
Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1545-1545 (2017)
Externí odkaz:
https://doaj.org/article/d8a4347a89dc4cd1bbda0b441052c4d6
Autor:
Nessa Banville, Janette K Burgess, Jade Jaffar, Gavin Tjin, Luca Richeldi, Stefania Cerri, Elisa Persiani, Judith L Black, Brian G Oliver
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105365 (2014)
Lymphangioleiomyomatosis (LAM) is a rare and progressive cystic lung condition affecting approximately 3.4-7.5/million women, with an average lag time between symptom onset and diagnosis of upwards of 4 years. The aim of this work was to identify alt
Externí odkaz:
https://doaj.org/article/4af9af2ec73e45d08c84b37b0e264465
Autor:
Alen Faiz, Gavin Tjin, Louise Harkness, Markus Weckmann, Shisan Bao, Judith L. Black, Brian G. G. Oliver, Janette K. Burgess
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/488cc069a6f24a5c91a592afeb1961f9
Autor:
Laura Keglowich, Michael Roth, Maria Philippova, Thérèse Resink, Gavin Tjin, Brian Oliver, Didier Lardinois, Sophie Dessus-Babus, Reinoud Gosens, Katrin Hostettler Haack, Michael Tamm, Peter Borger
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81494 (2013)
BackgroundAirway wall remodelling is a key pathology of asthma. It includes thickening of the airway wall, hypertrophy and hyperplasia of bronchial smooth muscle cells (BSMC), as well as an increased vascularity of the sub-epithelial cell layer. BSMC
Externí odkaz:
https://doaj.org/article/bdd7199be21c434f8aa214c3432b9e59
Autor:
Alen Faiz, Gavin Tjin, Louise Harkness, Markus Weckmann, Shisan Bao, Judith L Black, Brian G G Oliver, Janette K Burgess
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57245 (2013)
Tumstatin is an anti-angiogenic collagen IV α3 fragment, levels of which are reduced in the airways of asthmatics. Its reduction may be due to the degradation by extracellular matrix (ECM) proteases. Cathepsins play a role in ECM remodelling, with c
Externí odkaz:
https://doaj.org/article/773520963db848a391ec73e7b1113f90
Autor:
ShuhYing Tan, Chacko Joseph, Alistair M. Chalk, Jean Hendy, Stewart Fabb, Kelli Schleibs, Samuel C. Lee, Gavin Tjin, Clea S. Grace, Vinodini Madugalle, Monique F. Smeets, Ana C. Maluenda, Kim L. Rice, Emma K. Baker, Harshal Nandurkar, Christopher I. Slape, Michael W Parker, Ashwin Unnikrishnan, Ghulam J. Mufti, Magnus Tobiasson, Eva Hellstrom-Lindberg, John E. Pimanda, Lorraine J. Gudas, Jessica K. Holien, Carl R. Walkley, Meaghan Wall, Louise E. Purton
The homeobox gene,Hoxa1, has two different isoforms generated by alternative splicing: a full-length homeodomain-containingHoxa1(Hoxa1-FL), and a truncatedHoxa1(Hoxa1-T), that lacks the homeodomain. Oncoretroviral overexpression of wildtypeHoxa1cDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e33ff44b2fdccd0e106a5dee92ae00
https://doi.org/10.1101/2023.04.24.538176
https://doi.org/10.1101/2023.04.24.538176
Publikováno v:
Immunological Reviews. 302:47-67
B lymphocytes are crucial for the body's humoral immune response, secreting antibodies generated against foreign antigens to fight infection. Adult murine B lymphopoiesis is initiated in the bone marrow and additional maturation occurs in the spleen.
Autor:
Nataliya Migulina, Gavin Tjin, Alen Faiz, Theo Borghuis, Fenghua Zhao, Hans J. Kaper, Marit Metzlar, Eline van Dijk, Prashant K. Sharma, Wim Timens, Reinoud Gosens, Corry‐Anke Brandsma, Janette K. Burgess
Publikováno v:
The FASEB Journal. 36
Chronic obstructive pulmonary disease (COPD) is characterized by long-term airflow obstruction with cigarette smoke as a key risk factor. Extracellular matrix (ECM) alterations in COPD may lead to small airway wall fibrosis. Altered collagen cross-li