Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Gavin Thurston"'
Autor:
Dina M Flink, Se Jeong, Gavin Thurston, Rajat Bannerji, Vladimir Jankovic, Nathalie Fiaschi, Max S Topp, Jurriaan Brouwer-Visser, Raquel P Deering, Kamil J Cygan, Darius Scott, Lauren Boucher, Namita T Gupta, Suraj Gupta, Christina Adler, Johannes Duell, Ranjana H Advani, Aafia Chaudhry, Srikanth R Ambati
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) have a significant need for effective treatment options. Odronextamab is an Fc-silenced, human, CD20×CD3 bispecific antibody that targets CD20-expressing cells via
Externí odkaz:
https://doaj.org/article/f75c4ab13f95442dab8b823ea500c8c8
Autor:
Raquel P. Deering, Lili Blumenberg, Lianjie Li, Ankur Dhanik, Se Jeong, Stephane Pourpe, Hang Song, Lauren Boucher, Shoba Ragunathan, Yanxia Li, Maggie Zhong, Jessica Kuhnert, Christina Adler, Peter Hawkins, Namita T. Gupta, Michael Moore, Min Ni, Johanna Hansen, Yi Wei, Gavin Thurston
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Identifying epitopes that T cells respond to is critical for understanding T cell-mediated immunity. Traditional multimer and other single cell assays often require large blood volumes and/or expensive HLA-specific reagents and provide limit
Externí odkaz:
https://doaj.org/article/7093cc5d822c4b288df26b94fb08b8c9
Autor:
Wen Lin, Varan Singh, Raynel Springer, Gabrielle Choonoo, Namita Gupta, Aditi Patel, Davor Frleta, Jun Zhong, Tomasz Owczarek, Corinne Decker, Lynn Macdonald, Andrew Murphy, Gavin Thurston, Markus Mohrs, Ella Ioffe, Yi-Fen Lu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here, we report potent CD4 T cell
Externí odkaz:
https://doaj.org/article/64efdbe7ee8b495ea8268fb772fa6467
Autor:
A. K. Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew Murphy, Cagan Gurer, Davor Frleta
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However, such HIS mice typically exhibit sub-optimal respons
Externí odkaz:
https://doaj.org/article/d1f7faccd78644f2a9be6e7e0712f9dc
Autor:
Eunhyeong Lee, Sophie O’Keefe, Alessandra Leong, Ha-Ram Park, Janani Varadarajan, Subrata Chowdhury, Shannon Hiner, Sungsoo Kim, Anahita Shiva, Richard A. Friedman, Helen Remotti, Tito Fojo, Hee Won Yang, Gavin Thurston, Minah Kim
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half of patients with PanNETs present with liver metastases, and this accounts for the majority of patient mortality. We identified angiopoiet
Externí odkaz:
https://doaj.org/article/eaf9a3bca30a429d8677f001514daa1e
Autor:
Marisa Carbonaro, Jeffrey Lee, Evangelos Pefanis, Mathieu Desclaux, Kehui Wang, Alexander Pennington, Hui Huang, Alejo Mujica, Jose Rojas, Roxanne Ally, Daniel Kennedy, Michael Brown, Vitaliy Rogulin, Sven Moller-Tank, Leah Sabin, Brian Zambrowicz, Gavin Thurston, Zhe Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Humanized liver rodent models, in which the host liver parenchyma is repopulated by human hepatocytes, have been increasingly used for drug development and disease research. Unlike the leading humanized liver mouse model in which Fumarylacet
Externí odkaz:
https://doaj.org/article/f36f9f2973d74161ab4380d6be2edfb7
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
Gavin Thurston, Richard Tavare, Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Makenzie Danton, Christian Granados, Ishita Chatterjee, Drew Dudgeon, Marc W Retter, Dangshe Ma, William C Olson, Jessica R Kirshner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/e9dd493986824827a77c38864a866af9
Autor:
Gavin Thurston, Richard Tavare, Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Makenzie Danton, Christian Granados, Ishita Chatterjee, Drew Dudgeon, Marc W Retter, Dangshe Ma, William C Olson, Jessica R Kirshner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) blocking antibodies including cemiplimab have generated profound clinical activity across diverse cancer types. Tumorous PD-L1 expression, as assessed by immunohistoche
Externí odkaz:
https://doaj.org/article/95ca884fb1ff45408c623ba0079af2dc
Autor:
Gavin Thurston, Israel Lowy, Vladimir Jankovic, Myles Dillon, Lianjie Li, Jeongsook Bang, Nicholas Gaspar, Jessica Kuhnert, Nathalie Fiaschi, Glenn Kroog, Kyoung Soo Ha, Raquel Deering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/3f1437173aa144e8a97fc38bac8a4c3b