Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Gavin P. Davey"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109940- (2024)
Summary: SARM1 is a Toll-IL-1 receptor (TIR) domain-containing protein with roles in innate immunity and neuronal death in diverse organisms. Unlike other innate immune TIR proteins that function as adaptors for Toll-like receptors (TLRs), SARM1 has
Externí odkaz:
https://doaj.org/article/b9cd6b1ada9349c2a02f8782042eb623
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Human milk oligosaccharides (HMOs) form the third most abundant component of human milk and are known to convey several benefits to the neonate, including protection from viral and bacterial pathogens, training of the immune system, and infl
Externí odkaz:
https://doaj.org/article/51043afb2a76474da499b4a915f9742f
Autor:
Andrew G. McDonald, Gavin P. Davey
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 739-748 (2021)
Gangliosides are an important class of sialylated glycosphingolipids linked to ceramide that are a component of the mammalian cell surface, especially those of the central nervous system, where they function in intercellular recognition and communica
Externí odkaz:
https://doaj.org/article/863fa5ea5fc4475cb55202108d945857
Autor:
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
Externí odkaz:
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Mitochondrial dysfunction is a recognized hallmark of neurodegenerative diseases and abnormal mitochondrial fusion-fission dynamics have been implicated in the pathogenesis of neurodegenerative disorders. This study characterizes the effects of metab
Externí odkaz:
https://doaj.org/article/19575c37d04f422398c44ab3ad7e8237
Mitochondrial electron transport chain (ETC) complexes are key mediators of energy metabolism in astrocytes and neurons, with subsequent effects on memory, behaviour and neurodegeneration. Mitochondrial dysfunction and increased blood brain barrier (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dc8411a797bfebc0626884f2cb87460
https://doi.org/10.1101/2022.10.13.512023
https://doi.org/10.1101/2022.10.13.512023
Publikováno v:
Neurochemical Research. 46:100-107
Reductions in the activities of mitochondrial electron transport chain (ETC) enzymes have been implicated in the pathogenesis of numerous chronic neurodegenerative disorders. Maintenance of the mitochondrial membrane potential (Δψm) is a primary fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc5d529a9d93c8fdbe4b308d672e58
https://doi.org/10.1007/s11064-020-02990-8
https://doi.org/10.1007/s11064-020-02990-8
Publikováno v:
Scientific reports. 12(1)
Human milk oligosaccharides (HMOs) form the third most abundant component of human milk and are known to convey several benefits to the neonate, including protection from viral and bacterial pathogens, training of the immune system, and influencing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8232ffaa47bc3a72d77fa3a287f25b9
https://pubmed.ncbi.nlm.nih.gov/35760821
https://pubmed.ncbi.nlm.nih.gov/35760821
Autor:
Gavin P. Davey, Andrew G. McDonald
Publikováno v:
Glycosylation ISBN: 9781071616840
The web application O-Glycologue provides an online simulation of the biosynthetic enzymes of O-linked glycosylation, using a knowledge-based system described previously. Glycans can be imported in GlycoCT condensed format, or else as IUPAC condensed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac55275953458463ea546d91357d2e7
https://doi.org/10.1007/978-1-0716-1685-7_11
https://doi.org/10.1007/978-1-0716-1685-7_11
Publikováno v:
Glycosylation ISBN: 9781071616840
The sialome or display of sialic acids on the surface of human immune cells can vary according to immune response and activation state. Here, human peripheral blood mononuclear cells (PBMCs) were isolated and activated with anti-CD3 antibody and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74889844cb2d7732df2009cb57d2c5cf
https://doi.org/10.1007/978-1-0716-1685-7_17
https://doi.org/10.1007/978-1-0716-1685-7_17