Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Gavin P Dunn"'
Autor:
David M Kranz, Michael J White, Mao Li, Maximilian O Schaettler, Rupen Desai, Anthony Z Wang, Alexandra J Livingstone, Dale K Kobayashi, Andrew T Coxon, Jay A Bowman-Kirigin, Connor J Liu, Diane E Bender, Tanner M Johanns, Gavin P Dunn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Adoptive cellular therapies with chimeric antigen receptor T cells have revolutionized the treatment of some malignancies but have shown limited efficacy in solid tumors such as glioblastoma and face a scarcity of safe therapeutic targets.
Externí odkaz:
https://doaj.org/article/67ba15afade74b8a9caa7534c5ef5ce0
Autor:
Andrew Coxon, Rupen Desai, Tanner M Johanns, Gavin P Dunn, Saad M Khan, Alexandra Livingstone, Allegra Petti
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Glioblastoma is a fatal disease despite aggressive multimodal therapy. PD-1 blockade, a therapy that reinvigorates hypofunctional exhausted CD8 T cells (Tex) in many malignancies, has not shown efficacy in glioblastoma. Loss of CD4 T cells
Externí odkaz:
https://doaj.org/article/e57e0b22c39e49c4bbbdfaaa8929a27b
Autor:
Diane Elizabeth Bender, Maximilian O Schaettler, Kathleen CF Sheehan, Tanner M Johanns, Gavin P Dunn
Publikováno v:
Biomarker Insights, Vol 16 (2021)
We compared the performance of two 96-well multiplex immunoassay platforms in assessing plasma cytokine concentrations in patients with glioblastoma (GBM; n = 27), individuals with melanoma, breast or lung cancer metastases to the brain (n = 17), and
Externí odkaz:
https://doaj.org/article/c7ac1568321f4f3dbd87e1e371cccb74
Autor:
Yu Mei, Wenya Linda Bi, Noah F Greenwald, Nathalie Y Agar, Rameen Beroukhim, Gavin P Dunn, Ian F Dunn
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178322 (2017)
Meningiomas, derived from arachnoid cap cells, are the most common intracranial tumor. High-grade meningiomas, as well as those located at the skull base or near venous sinuses, frequently recur and are challenging to manage. Next-generation sequenci
Externí odkaz:
https://doaj.org/article/4bbe0150d60d40fb82f2006bd3076ee0
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
There is great promise that ongoing advances in the delivery of therapeutics to the central nervous system (CNS) combined with rapidly expanding knowledge of brain tumor patho-biology will provide new, more effective therapies. Brain tumors that form
Externí odkaz:
https://doaj.org/article/db3156f2302f494c9207be383c6bfa1a
Autor:
Anthony Z. Wang, Jay A. Bowman-Kirigin, Rupen Desai, Liang-I Kang, Pujan R. Patel, Bhuvic Patel, Saad M. Khan, Diane Bender, M. Caleb Marlin, Jingxian Liu, Joshua W. Osbun, Eric C. Leuthardt, Michael R. Chicoine, Ralph G. Dacey, Gregory J. Zipfel, Albert H. Kim, David G. DeNardo, Allegra A. Petti, Gavin P. Dunn
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-25 (2022)
Abstract Background Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from t
Externí odkaz:
https://doaj.org/article/c17233161de54fbe91f8411660beec7a
Autor:
Jay A. Bowman-Kirigin, Rupen Desai, Brian T. Saunders, Anthony Z. Wang, Maximilian O. Schaettler, Connor J. Liu, Alexandra J. Livingstone, Dale K. Kobayashi, Vivek Durai, Nicole M. Kretzer, Gregory J. Zipfel, Eric C. Leuthardt, Joshua W. Osbun, Michael R. Chicoine, Albert H. Kim, Kenneth M. Murphy, Tanner M. Johanns, Bernd H. Zinselmeyer, Gavin P. Dunn
Publikováno v:
Cancer Immunology Research. 11:20-37
The central nervous system (CNS) antigen-presenting cell (APC) that primes antitumor CD8+ T-cell responses remains undefined. Elsewhere in the body, the conventional dendritic cell 1 (cDC1) performs this role. However, steady-state brain parenchyma c
Autor:
Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 512-522 (2018)
Summary: Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. C
Externí odkaz:
https://doaj.org/article/04d19f65202b4edbba608a484043e571
Autor:
Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn
Publikováno v:
OncoImmunology, Vol 8, Iss 4 (2019)
Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors like glioblastoma (GBM) remains unknown. We have previously reported the use of an immunog
Externí odkaz:
https://doaj.org/article/8dde9e453942466c919f33fd089ee9d6
Autor:
Gavin P. Dunn, Bernd H. Zinselmeyer, Tanner M. Johanns, Kenneth M. Murphy, Albert H. Kim, Michael R. Chicoine, Joshua W. Osbun, Eric C. Leuthardt, Gregory J. Zipfel, Nicole M. Kretzer, Vivek Durai, Dale K. Kobayashi, Alexandra J. Livingstone, Connor J. Liu, Maximilian O. Schaettler, Anthony Z. Wang, Brian T. Saunders, Rupen Desai, Jay A. Bowman-Kirigin
Supplementary Figures and Tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ee81d152485914d2570e049914be76
https://doi.org/10.1158/2326-6066.22546134.v1
https://doi.org/10.1158/2326-6066.22546134.v1