Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gavin M. Davis"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109940- (2024)
Summary: SARM1 is a Toll-IL-1 receptor (TIR) domain-containing protein with roles in innate immunity and neuronal death in diverse organisms. Unlike other innate immune TIR proteins that function as adaptors for Toll-like receptors (TLRs), SARM1 has
Externí odkaz:
https://doaj.org/article/b9cd6b1ada9349c2a02f8782042eb623
Autor:
Leonard R. Pelgrom, Gavin M. Davis, Simon O’Shaughnessy, Emilie J.M. Wezenberg, Sander I. Van Kasteren, David K. Finlay, Linda V. Sinclair
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112828- (2023)
Summary: System-level analysis of single-cell data is rapidly transforming the field of immunometabolism. Given the competitive demand for nutrients in immune microenvironments, there is a need to understand how and when immune cells access these nut
Externí odkaz:
https://doaj.org/article/f8ed02eb6f6c4fc3b2176333693c7e6f
Autor:
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
Externí odkaz:
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Mitochondrial dysfunction is a recognized hallmark of neurodegenerative diseases and abnormal mitochondrial fusion-fission dynamics have been implicated in the pathogenesis of neurodegenerative disorders. This study characterizes the effects of metab
Externí odkaz:
https://doaj.org/article/19575c37d04f422398c44ab3ad7e8237
Mitochondrial electron transport chain (ETC) complexes are key mediators of energy metabolism in astrocytes and neurons, with subsequent effects on memory, behaviour and neurodegeneration. Mitochondrial dysfunction and increased blood brain barrier (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dc8411a797bfebc0626884f2cb87460
https://doi.org/10.1101/2022.10.13.512023
https://doi.org/10.1101/2022.10.13.512023
Autor:
Fidinny I. Hamid, Gavin P. Davey, Paul J. Hertzog, Conor P. Duffy, Tracy Robson, Daniel J. Gough, Nadine Assmann, Katja Dettmer, Ed C. Lavelle, Christoph Hess, Anne M. Curtis, Bryan R.G. Williams, Frances K. Nally, Aoife L. Gorman, Gavin M. Davis, Claire E. McCoy, Glenn R. Bantug, David K. Finlay, Stephanie Annett, Jennifer K. Dowling, Chiara De Santi, Alex M. Liddicoat, Mariana P. Cervantes-Silva, Remsha Afzal, Peter J. Oefner, Linden J. Gearing
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b0faed67a34997f9e8c7dd17348590
https://www.repository.cam.ac.uk/handle/1810/318448
https://www.repository.cam.ac.uk/handle/1810/318448
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Autor:
Dowling, Jennifer K., Afzal, Remsha, Gearing, Linden J., Cervantes-Silva, Mariana P., Annett, Stephanie, Davis, Gavin M., De Santi, Chiara, Assmann, Nadine, Dettmer, Katja, Gough, Daniel J., Bantug, Glenn R., Hamid, Fidinny I., Nally, Frances K., Duffy, Conor P., Gorman, Aoife L., Liddicoat, Alex M., Lavelle, Ed C., Hess, Christoph, Oefner, Peter J., Finlay, David K.
Publikováno v:
Nature Communications; 3/5/2021, Vol. 12 Issue 1, p1-14, 14p
Publikováno v:
Frontiers in Molecular Neuroscience; 9/18/2019, p1-10, 10p