Limiting life-sustaining treatment for very old ICU patients: cultural challenges and diverse practices

Autor: Michael Beil, Peter Vernon van Heerden, Gavin M. Joynt, Stephen Lapinsky, Hans Flaatten, Bertrand Guidet, Dylan de Lange, Susannah Leaver, Christian Jung, Daniel Neves Forte, Du Bin, Muhammed Elhadi, Wojciech Szczeklik, Sigal Sviri

Publikováno v: Annals of Intensive Care, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract Background Decisions about life-sustaining therapy (LST) in the intensive care unit (ICU) depend on predictions of survival as well as the expected functional capacity and self-perceived quality of life after discharge, especially in very ol

Externí odkaz: https://doaj.org/article/35edc6ddef4448668fc44b570c28d92f

Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill

Autor: Spyros D. Mentzelopoulos, Su Chen, Joseph L. Nates, Jacqueline M. Kruser, Christiane Hartog, Andrej Michalsen, Nikolaos Efstathiou, Gavin M. Joynt, Suzana Lobo, Alexander Avidan, Charles L. Sprung, the End-of-life Practice Score Study Group

Publikováno v: Critical Care, Vol 26, Iss 1, Pp 1-14 (2022)

Abstract Background Limitations of life-sustaining interventions in intensive care units (ICUs) exhibit substantial changes over time, and large, contemporary variation across world regions. We sought to determine whether a weighted end-of-life pract

Externí odkaz: https://doaj.org/article/863245d72a2a4f26acb567ee658f68c1

Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

Autor: David Conen, Ekaterine Popova, Michael Ke Wang, Matthew T.V. Chan, Giovanni Landoni, Cara Reimer, Sadeesh K. Srinathan, Juan P. Cata, Sean R. McLean, Juan Carlos Trujillo Reyes, Ascensión Martín Grande, Anna Gonzalez Tallada, Daniel I. Sessler, Edith Fleischmann, Donna E. Maziak, Barbara Kabon, Luca Voltolini, Laura Gutiérrez-Soriano, Vikas Tandon, Deborah DuMerton, Biniam Kidane, Ravi Rajaram, Yaron Shargall, John D. Neary, Jennifer R. Wells, William F. McIntyre, Steffen Blum, Sandra N. Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, Jeff S. Healey, Amit X. Garg, PJ Devereaux, null Devereaux, Mohammed Amir, Shrikant I. Bangdiwala, Matthias Bossard, John W. Eikelboom, Sanjit S. Jolly, Felix Ramón Montes, Denis Schmartz, Chew Yin Wang, Jesus Alvarez-Garcia, Giuliana Lo Bianco, Danielle de Sa Boasquevisque, Flavia K. Borges, Helene Chiarella-Redfern, Aranzazu Gonzalez-Osuna, Jose M. Guerra-Ramos, Maura Marcucci, Pascal B. Meyre, Christopher Oleynick, Anna Ramos-Pachón, Hugh Traquair, L. Brent Mitchell, George Wyse, Davy Cheng, Finlay A. McAlister, George A. Wells, Geethan Baskaran, Julia Gennaccaro, Rosemary Howe, Louise Mastrangelo, Shirley Pettit, Subana Shahbaz, Makayla Tosh, Simona J. Zucchetto, Laura Heenan, Shun Fu Lee, Christian Reiterer, Alexander Taschner, Katharina Horvath, Nikolas Adamowitsch, Oliver Zotti, Nicole Hantáková, Beatrix Hochreiter, Isabelle Huybrechts, Serge Cappeliez, Christian Finley, John Agzarian, Waël Hanna, Muammar Abdulrahman, Kelly Lawrence, Krysten Gregus, Faraaz Quraishi, Spencer Wikkerink, Christine Wallace, Merissa Prine, Emily Gregus, Jacqueline Hare, Kristen Lombardo, Behashta Fezia, Teresa Columbus, Ken Reid, Joel Parlow, Wiley Chung, Maria Karizhenskaia, Aftab Malik, Richard Liu, Lawrence Tan, Stephen Gowing, Gordon Buduhan, Stephanie Enns, Emma Poole, Kristin Graham, Anna McGuire, Jens Lohser, Shirley Lim, Rebecca Grey, Kyle Grant, Alex L. Lee, James J. Choi, Leith R. Dewar, John Yee, Andrew J.E. Seely, Sebastien Gilbert, P. James Villeneuve, Sudhir Sundaresan, Susan D. Moffatt-Bruce, Molly Gingrich, Anna Fazekas, Kirby Bucciero, Richard A. Malthaner, Deb Lewis, Dalilah Fortin, Mehdi Qiabi, Rahul Nayak, Madelaine Marie Plourde, Daniel Sellers, Laura Donahoe, Marco Lefebvre, Luc Lanthier, Colin Schieman, Amal Bessissow, Gavin M. Joynt, Randolph H.L. Wong, Rainbow W.H. Lau, Wai Tat Wong, Gordon Y.S. Choi, Eva Lee, Ka Yan Hui, Beaker Fung, Chee Sam Chan, Laura Carmenza Castañeda, Luis Jaime Téllez, Lina Marcela Ortiz-Ramirez, Simona De Santis, Giovanni Favaro, Piergiorgio Muriana, Cristina Nakhnoukh, Pierluigi Novellis, Stefano Turi, Giulia Veronesi, Matteo Angelini, Stefano Bongiolatti, Alberto Salvicchi, Lavinia Gatteschi, Rossella Indino, Simone Tombelli, Alice Ravasin, Ottavia Salimbene, Giulio Luca Rosboch, Eleonora Balzani, Domenico Massullo, Silvia Fiorelli, Francesco Londero, William Grossi, Tyng Yan Ng, Woan Shiang See, Mohammed Asghar Nawaz, Elisabeth Martinez Tellez, Josep Belda Sanchis, Georgina Planas Cánovas, Ana Parera Ruiz, Esther Cladellas Gutierrez, Mauro Guarino, Gerard Urrutia Cuchi, Marta Argilaga Nogues, Anna Rovira Juan, Melixa Medina-Aedo, Diego Parise Roux, Luis Gajate Martín, Angélica De Pablo Pajares, Angel Manuel Candela Toha, Nicolás Moreno Mata, Gema Muñoz Molina, Usue Caballero Silva, Alberto Cabañero, Sara Fra Fernandez, Anna Gonzàlez Tallada, Susana González Suarez, Montserrat Ribas Ball, Miriam De Nadal Clanchet, Laura Ruiz-Villa, M.M. Martí-Ejarque, Mireia Gili-Bueno, Jorge Hernández Ferrández, Neus Pons Llobet, Patricia Cruz, Guillermo Sánchez-Pedrosa, Patricia Duque, Leire Azcárate, Lorena Martín-Albo, Alberto Rodríguez-Fuster, Silvia Bermejo-Martínez, Albert Carramiñana, Fabrizio Minervini, German Corrales, Juan Jose Guerra-Londono, Reza Mehran, Boris Sepesi, Garrett Walsh, Daniel S. Cukierman, Bryan E. Marchant, Lynne C. Harris, Bruce D. Cusson, Scott A. Miller, Steven C. Minear, Camila Teixeira, Mario Pimentel, Andrew M. Popoff, Wing Lee Cheung, Kelly Marsack, Sabry Ayad, Jorge Araujo, Tzonghuei H. Chen, Michael Essandoh, Jeremy S. Poppers

Publikováno v: American Heart Journal. 259:87-96

Background: Perioperative atrial fibrillation (AF) and myocardial injury after noncardiac surgery (MINS) are common complications after noncardiac surgery. Inflammation has been implicated in the pathogenesis of both disorders. The COP-AF trial tests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affcfac2739206812593cba7b597738a
https://doi.org/10.1016/j.ahj.2023.01.018

Clinician preferences for prescription of corticosteroids in patients with septic shock: an international survey

Autor: Sarah Grattan, Yaseen M. Arabi, Tony Yeh, Anders Perner, Gavin M. Joynt, Flávia Ribeiro Machado, Vernon van Heerden, Balasubramanian Venkatesh, Andrew Rhodes, Naomi E Hammond, Gian Luca Di Tanna, Bharath Kumar Tirupakuzhi Vijayaraghavan, Ashwani Kumar, Royal Brisbane, Jeremy Cohen, Pain Intensive Care Anesthesiology, Rigshospitalet, Copenhagen, Denmark

Publikováno v: Critical Care and Resuscitation. 23:234-238

In 2010, following the publication of two large trials of corticosteroids in septic shock, an international survey of corticosteroid use in the management of septic shock reported marked variability in practice. Two large randomised controlled trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::def2302be89c2a6aea7c776ed38fd86e
https://doi.org/10.51893/2021.2.s1

Multicenter Population Pharmacokinetic Study of Unbound Ceftriaxone in Critically Ill Patients

Autor: Aaron J. Heffernan, Fekade B. Sime, Nilesh Kumta, Steven C. Wallis, Brett McWhinney, Jacobus Ungerer, Gloria Wong, Gavin M. Joynt, Jeffrey Lipman, Jason A. Roberts

Publikováno v: Antimicrob Agents Chemother

The objective of this study was to describe the total and unbound population pharmacokinetics of ceftriaxone in critically ill adult patients and to define optimized dosing regimens. Total and unbound ceftriaxone concentrations were obtained from two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e253fe3f6c88062d5f28264d413da96
https://doi.org/10.1128/aac.02189-21