Výsledky vyhledávání - "Gavin Landesberg"

Postprandial activation of leukocyte‐endothelium interaction by fatty acids in the visceral adipose tissue microcirculation

Autor: Zienab Etwebi, Inna Rom, Satoru Eguchi, Michael V. Autieri, Christine N. Vrakas, Gavin Landesberg, Rosario Scalia, Kyle Preston, Sanae Muraoka

Publikováno v: FASEB J

High-fat diet (HFD)-induced obesity is associated with accumulation of inflammatory cells predominantly in visceral adipose depots [visceral adipose tissue (VAT)] rather than in subcutaneous ones [subcutaneous adipose tissue (SAT)]. The cellular and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9608e96be9449973d002960d0e798624
https://doi.org/10.1096/fj.201802637rr

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Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging

Autor: Rajika Roy, Ancai Yuan, Christopher J. Traynham, Erhe Gao, Konstantinos Drosatos, Gavin Landesberg, Steven J. Forrester, Claudio de Lucia, Douglas G. Tilley, Walter J. Koch, Jessica Pfleger, Jennifer Petovic, Michela Piedepalumbo, Matthew Hoffman, Rosario Scalia, Laurel A. Grisanti, Melissa Lieu, Satoru Eguchi

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology

Nitric oxide (NO) and S-nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition of cardiac G protein-coupled r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9943b5d2886fbe4556ca902d4895978e
https://pubmed.ncbi.nlm.nih.gov/32216616

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Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

Autor: Lucia Russo, Rosario Scalia, Gavin Landesberg, Eric E. Morgan, Rajesh Gupta, Alexander Wisniewski, Guillermo Vazquez, Syed Quadri, Helmy M. Siragy, Harrison T. Muturi, Hilda E. Ghadieh, Sonia M. Najjar

Publikováno v: Molecular Metabolism, Vol 9, Iss, Pp 98-113 (2018)
Molecular Metabolism

Objective Mice with global null mutation of Ceacam1 (Cc1−/−), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a683791eba26cf21c44a9f2105f16e0
https://doi.org/10.1016/j.molmet.2018.01.009

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Abstract 841: Loss of S-nitrosylation of G Protein-Coupled Receptor Kinase 2 Leads to Cardiovascular Dysfunction With Aging

Autor: Steven J. Forrester, Christopher J. Traynham, Rosario Scalia, Gavin Landesberg, Satoru Eguchi, Erhe Gao, Walter J. Koch, Melissa Lieu, Jennifer Petovic

Publikováno v: Circulation Research. 125

Nitric oxide (NO) and S-nitrosothiol (SNO) have cardiovascular-protective properties and we have shown that one mechanism is through SNO-modification of G protein-coupled receptor (GPCR) kinase 2 (GRK2). S-nitrosylation at Cys340 (C340S) of GRK2 inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e44490f64afdb332dbc2f08358e22504
https://doi.org/10.1161/res.125.suppl_1.841

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Abstract 693: RNA Stability Protein ILF3 Mediates IL-19 Induced Angiogenesis

Autor: Gavin Landesberg, Christine N. Vrakas, Michael V. Autieri, Mitali Ray, Rosario Scalia, Sheri E. Kelemen, Allison B. Herman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 38

Angiogenesis is a physiological process vital for growth, development and wound healing but is also a promising therapeutic target for the treatment of ischemic cardiovascular disease. Presently, there is nothing known regarding the role of, the RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::591e1b09564a4d390a0d4e276324e724
https://doi.org/10.1161/atvb.38.suppl_1.693

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Abstract 602: The Role of Interleukin-19 in Adipose Tissue Homeostasis

Autor: Rosario Scalia, Michael V. Autieri, Gavin Landesberg, Mitali Ray, Christine N. Vrakas, Sheri E. Kelemen, Allison B. Herman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 38

Expanding adipose depots experience hypoxia and inflammation, a phenomenon considered pathogenic of metabolic and cardiovascular complications. Currently very little is known about the potential for endogenously expressed anti-inflammatory cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::446062e262ae1a72e5119a79494dd188
https://doi.org/10.1161/atvb.38.suppl_1.602

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Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase)

Autor: Gavin Landesberg, Zienab Etwebi, Kyle Preston, Rosario Scalia, Satoru Eguchi

Publikováno v: Hypertension (Dallas, Tex. : 1979). 71(4)

MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. The molecular mechanisms of the endothelial damaging action of MPO rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4418977cb45bd6c60933f7be5e2669
https://pubmed.ncbi.nlm.nih.gov/29507102

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Abstract 543: Myeloperoxidase Induces Endothelial Dysfunction via Activation of Calpain

Autor: Zienab Etwebi, Gavin Landesberg, Rosario Scalia

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37

Myeloperoxidase (MPO) is a peroxidase enzyme secreted by activated leukocytes, which has been associated with endothelial dysfunction and insulin resistance. The calcium dependent protease calpain has also been linked to vascular disease in insulin r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0192d0a93c2216bb2e09bdf7fb823d
https://doi.org/10.1161/atvb.37.suppl_1.543

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