Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Gavin J. Wright"'
Autor:
Rameswara R. Segireddy, Hugo Belda, Annie S. P. Yang, Kirsten Dundas, Julia Knoeckel, Francis Galaway, Laura Wood, Doris Quinkert, Ellen Knuepfer, Moritz Treeck, Gavin J. Wright, Alexander D. Douglas
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identif
Externí odkaz:
https://doaj.org/article/cd30976dbd8d4667bc3b6da3dc678722
Autor:
Adam J. Roberts, Han Boon Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Yegnasew Takele, Prakash Ghosh, Angela Toepp, Max Waugh, Daniel Matano, Anna Färnert, Emily Adams, Javier Moreno, Margaret Mbuchi, Christine Petersen, Dinesh Mondal, Pascale Kropf, Gavin J. Wright
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTVisceral leishmaniasis is a deadly infectious disease and is one of the world’s major neglected health problems. Because the symptoms of infection are similar to other endemic diseases, accurate diagnosis is crucial for appropriate treatmen
Externí odkaz:
https://doaj.org/article/67ae2e30573840219d270dc46cf08f7c
Autor:
Melissa N. Hart, Franziska Mohring, Sophia M. DonVito, James A. Thomas, Nicole Muller-Sienerth, Gavin J. Wright, Ellen Knuepfer, Helen R. Saibil, Robert W. Moon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs
Externí odkaz:
https://doaj.org/article/c48e41643e4c4f30a28ba70dc114bca3
Autor:
Jarrod Shilts, Thomas W. M. Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J. D. Greenwood, Samuel James Watson, Brian M. Ortmann, Christian M. Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A. Nathan, Stefan Pöhlmann, Nicholas J. Matheson, Paul J. Lehner, Gavin J. Wright
Publikováno v:
PLoS Biology, Vol 21, Iss 2 (2023)
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein is the largest structural compon
Externí odkaz:
https://doaj.org/article/90f98ee96aff4b489c474fa416cf8b43
Autor:
Adam Roberts, Rupa Nagar, Cordelia Brandt, Katherine Harcourt, Simon Clare, Michael A. J. Ferguson, Gavin J. Wright
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Visceral leishmaniasis is a deadly infectious disease caused by Leishmania donovani, a kinetoplastid parasite for which no licensed vaccine is available. To identify potential vaccine candidates, we systematically identified genes encoding p
Externí odkaz:
https://doaj.org/article/6ee10168e049486aa4ff08e04fd53677
Autor:
Enrica Bianchi, Yi Sun, Alexandra Almansa-Ordonez, Michael Woods, David Goulding, Nadia Martinez-Martin, Gavin J. Wright
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lack of correct embryo transport can cause ectopic pregnancy. Here, the authors show that female mice lacking the adhesion G-protein coupled receptor Adgrd1 are infertile, due to embryos being trapped in the ampulla as the result of dysregulated ovid
Externí odkaz:
https://doaj.org/article/22fbc19c7d8d408483697d387763d42a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early stud
Externí odkaz:
https://doaj.org/article/985b50f6b24543619791a2c52c0f7f97
A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance
Autor:
Nicole Müller-Sienerth, Jarrod Shilts, Khamisah Abdul Kadir, Victor Yman, Manijeh Vafa Homann, Muhammad Asghar, Billy Ngasala, Balbir Singh, Anna Färnert, Gavin J. Wright
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background Malaria remains a global health problem and accurate surveillance of Plasmodium parasites that are responsible for this disease is required to guide the most effective distribution of control measures. Serological surveillance wil
Externí odkaz:
https://doaj.org/article/1c8b9be6d2284b0e85f24535e91a99d7
Autor:
William R. Proto, Sasha V. Siegel, Selasi Dankwa, Weimin Liu, Alison Kemp, Sarah Marsden, Zenon A. Zenonos, Steve Unwin, Paul M. Sharp, Gavin J. Wright, Beatrice H. Hahn, Manoj T. Duraisingh, Julian C. Rayner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Here, Proto et al. show that human infective Plasmodium falciparum isolates contain an inactivating mutation in the erythrocyte invasion associated gene PfEBA165, while homologues of ape-infective Laverania species are intact, and that expression of
Externí odkaz:
https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5f2338a76305403a845902ff952f8ef4