Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Gavin J. Wright"'
Autor:
Rameswara R. Segireddy, Hugo Belda, Annie S. P. Yang, Kirsten Dundas, Julia Knoeckel, Francis Galaway, Laura Wood, Doris Quinkert, Ellen Knuepfer, Moritz Treeck, Gavin J. Wright, Alexander D. Douglas
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identif
Externí odkaz:
https://doaj.org/article/cd30976dbd8d4667bc3b6da3dc678722
Autor:
Adam J. Roberts, Han Boon Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Yegnasew Takele, Prakash Ghosh, Angela Toepp, Max Waugh, Daniel Matano, Anna Färnert, Emily Adams, Javier Moreno, Margaret Mbuchi, Christine Petersen, Dinesh Mondal, Pascale Kropf, Gavin J. Wright
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTVisceral leishmaniasis is a deadly infectious disease and is one of the world’s major neglected health problems. Because the symptoms of infection are similar to other endemic diseases, accurate diagnosis is crucial for appropriate treatmen
Externí odkaz:
https://doaj.org/article/67ae2e30573840219d270dc46cf08f7c
Publikováno v:
eLife, Vol 13 (2024)
A crucial event in sexual reproduction is when haploid sperm and egg fuse to form a new diploid organism at fertilization. In mammals, direct interaction between egg JUNO and sperm IZUMO1 mediates gamete membrane adhesion, yet their role in fusion re
Externí odkaz:
https://doaj.org/article/13a1e1b1357d4508b67637d384f38c9c
Autor:
Melissa N. Hart, Franziska Mohring, Sophia M. DonVito, James A. Thomas, Nicole Muller-Sienerth, Gavin J. Wright, Ellen Knuepfer, Helen R. Saibil, Robert W. Moon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs
Externí odkaz:
https://doaj.org/article/c48e41643e4c4f30a28ba70dc114bca3
Autor:
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001959 (2023)
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein is the largest structural compon
Externí odkaz:
https://doaj.org/article/b29561a147434b44ba62633c5cedb4fe
Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface.
Autor:
Alessandra Romero-Ramirez, Aitor Casas-Sánchez, Delphine Autheman, Craig W Duffy, Cordelia Brandt, Simon Clare, Katherine Harcourt, Marcos Rogério André, Kayo José Garcia de Almeida Castilho Neto, Marta M G Teixeira, Rosangela Zacharias Machado, Janine Coombes, Robin J Flynn, Gavin J Wright, Andrew P Jackson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010791 (2022)
Trypanosoma vivax is a unicellular hemoparasite, and a principal cause of animal African trypanosomiasis (AAT), a vector-borne and potentially fatal livestock disease across sub-Saharan Africa. Previously, we identified diverse T. vivax-specific gene
Externí odkaz:
https://doaj.org/article/89483fc1415d498f90bc0e90ff0c6551
Autor:
Adam Roberts, Rupa Nagar, Cordelia Brandt, Katherine Harcourt, Simon Clare, Michael A. J. Ferguson, Gavin J. Wright
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Visceral leishmaniasis is a deadly infectious disease caused by Leishmania donovani, a kinetoplastid parasite for which no licensed vaccine is available. To identify potential vaccine candidates, we systematically identified genes encoding p
Externí odkaz:
https://doaj.org/article/6ee10168e049486aa4ff08e04fd53677
Autor:
Enrica Bianchi, Yi Sun, Alexandra Almansa-Ordonez, Michael Woods, David Goulding, Nadia Martinez-Martin, Gavin J. Wright
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lack of correct embryo transport can cause ectopic pregnancy. Here, the authors show that female mice lacking the adhesion G-protein coupled receptor Adgrd1 are infertile, due to embryos being trapped in the ampulla as the result of dysregulated ovid
Externí odkaz:
https://doaj.org/article/22fbc19c7d8d408483697d387763d42a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early stud
Externí odkaz:
https://doaj.org/article/985b50f6b24543619791a2c52c0f7f97
Autor:
Adam J Roberts, Han B Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Susanne U Franssen, James A Cotton, Nicole Müller-Sienerth, Gavin J Wright
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010364 (2022)
Leishmaniasis is an infectious disease caused by protozoan parasites belonging to the genus Leishmania for which there are no approved human vaccines. Infections localise to different tissues in a species-specific manner with the visceral form of the
Externí odkaz:
https://doaj.org/article/96d36f9863694b608b562da01b02fe21