Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Gavin J. Williams"'
Autor:
Edward Kalkreuter, Kyle S. Bingham, Aaron M. Keeler, Andrew N. Lowell, Jennifer J. Schmidt, David H. Sherman, Gavin J. Williams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Engineering efforts have focused on acyltransferase (AT) domains of modular polyketide synthases (PKSs) to site-selectively modify the resulting polyketides, but critical AT residues involved in substrate selection have not been fully elucidated. Her
Externí odkaz:
https://doaj.org/article/8ac2f471c63242d2830d7699ac214224
Publikováno v:
Chem Catalysis. 2:2440-2443
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81ecf1cda63c55e6f5f5ffc5e6a6037b
https://doi.org/10.1016/j.checat.2022.09.042
https://doi.org/10.1016/j.checat.2022.09.042
Publikováno v:
ACS Synth Biol
Clarithromycin is an improved semi-synthetic analogue of the naturally occurring macrolide, erythromycin. The subtle modification of a methyl group on the C-6 hydroxyl group endows the molecule with improved acid stability and results in a clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141a03f6306629a94b18ebc4e7f60d9a
https://doi.org/10.1021/acssynbio.1c00151
https://doi.org/10.1021/acssynbio.1c00151
Publikováno v:
Curr Opin Chem Biol
The full potential of polyketide discovery has yet to be reached due to a lack of suitable technologies and knowledge required to advance engineering of polyketide biosynthesis. Recent investigations on the discovery, enhancement, and non-natural uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fb17ae340b7260fbfb2aee9033fbe5
https://doi.org/10.1016/j.cbpa.2020.06.003
https://doi.org/10.1016/j.cbpa.2020.06.003
Publikováno v:
J Ind Microbiol Biotechnol
Isoprenoids are a large class of natural products with myriad applications as bioactive and commercial compounds. Their diverse structures are derived from the biosynthetic assembly and tailoring of their scaffolds, ultimately constructed from two C5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4d5285533cc2571f01e7522c5f0e56
https://doi.org/10.1007/s10295-020-02306-3
https://doi.org/10.1007/s10295-020-02306-3
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-15 (2020)
Journal of Cheminformatics
Journal of Cheminformatics
We report on a new cheminformatics enumeration technology—SIME, synthetic insight-based macrolide enumerator—a new and improved software technology. SIME can enumerate fully assembled macrolides with synthetic feasibility by utilizing the constit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e0c1f1afa3e42ef1651c16f1d8d633
http://link.springer.com/article/10.1186/s13321-020-00427-6
http://link.springer.com/article/10.1186/s13321-020-00427-6
Publikováno v:
Nature Catalysis. 3:536-538
Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6705d3384c0c3001708a239379064431
https://doi.org/10.1038/s41929-020-0483-4
https://doi.org/10.1038/s41929-020-0483-4
Autor:
Aaron M Keeler, Gavin J. Williams, Kyle S Bingham, David H. Sherman, Jennifer J. Schmidt, Edward Kalkreuter, Andrew N. Lowell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88e9c6a4d96ed4ab4f7466846186634
https://hdl.handle.net/10919/104639
https://hdl.handle.net/10919/104639
Publikováno v:
Protein Eng Des Sel
As protein engineering grows more salient, many strategies have emerged to alter protein structure and function, with the goal of redesigning and optimizing natural product biosynthesis. Computational tools, including machine learning and molecular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20db0317e76d419d1f78f0553034b82
https://pubmed.ncbi.nlm.nih.gov/34137436
https://pubmed.ncbi.nlm.nih.gov/34137436
Publikováno v:
Curr Opin Biotechnol
Natural products and their derivatives offer a rich source of chemical and biological diversity; however, traditional engineering of their biosynthetic pathways to improve yields and access to unnatural derivatives requires a precise understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a7993a6ae0915069b424f61e7e11f9
https://pubmed.ncbi.nlm.nih.gov/33493842
https://pubmed.ncbi.nlm.nih.gov/33493842