Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gavin J. McDonald"'
Autor:
Rahul C Deo, Nick Patterson, Arti Tandon, Gavin J McDonald, Christopher A Haiman, Kristin Ardlie, Brian E Henderson, Sean O Henderson, David Reich
Publikováno v:
PLoS Genetics, Vol 3, Iss 11, p e196 (2007)
Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a large-scale admixture scan for ge
Externí odkaz:
https://doaj.org/article/f47788c5b4df4f7292741f2ed58ace6a
Autor:
F. Tylavsky, Gavin J. McDonald, J. A. Cauley, A.B. Newman, John R. Shaffer, Joseph M. Zmuda, Nick Patterson, Tamara B. Harris, Douglas C. Bauer, Robert E. Ferrell, Jian-Mei Li, Candace M. Kammerer, Bret H. Goodpaster, David Reich
Publikováno v:
Osteoporosis International. 18:733-741
Individual-specific percent European ancestry was assessed in 1,277 African Americans. We found significant correlations between proportion of European ancestry and several musculoskeletal traits, indicating that admixture mapping may be a useful str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b68dfce980cf06580122f11aa4b0b43
https://doi.org/10.1007/s00198-006-0316-6
https://doi.org/10.1007/s00198-006-0316-6
Autor:
Gavin J. McDonald, Francisco M. De La Vega, Kwabena A. Poku, David A. Hafler, David Vlahov, Dennis A. Gilbert, Bailey Kessing, Alicja Waliszewska, J. P. Phair, Michael W. Smith, Michael Malasky, John J. Sninsky, J L Sankalé, Ernest Le, Zeng Yi, Charles R. Scafe, David Altshuler, Cheryl A. Winkler, Ann L. Truelove, Jason H. Moore, Myron Essex, James A. Lautenberger, David Reich, Stephen J. O'Brien, Scott M. Williams, Philip L. De Jager, Sarah A. Tishkoff, James J. Goedert, Nick Patterson, Trevor Woodage, Andre A. Mignault
Publikováno v:
The American Journal of Human Genetics. 74(5):1001-1013
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf06eae831c54da43c1e6a1ea4f8fb2
Publikováno v:
Aquaculture. 233:65-78
We evaluate the utility of a relatedness estimator ( r ) as a tool for inbreeding avoidance in three aquaculture strains of rainbow trout ( Oncorhynchus mykiss ) that show different amounts of genetic variation. The predicted distributions of r value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a3d2f0aafc631c07bc034f5d28e13d8
https://doi.org/10.1016/j.aquaculture.2003.08.003
https://doi.org/10.1016/j.aquaculture.2003.08.003
Autor:
Stacey Gabriel, Laurence N. Kolonel, Matthew L. Freedman, David Altshuler, Michele T. Pato, Eric J. Topol, Andre A. Mignault, Pamela Sklar, Carlos N. Pato, Gavin J. McDonald, Brian E. Henderson, Nick Patterson, Tracey L. Petryshen, Joel N. Hirschhorn, Jordan W. Smoller, David Reich, Eric S. Lander, Kathryn L. Penney
Publikováno v:
Nature Genetics. 36:388-393
Population stratification refers to differences in allele frequencies between cases and controls due to systematic differences in ancestry rather than association of genes with disease. It has been proposed that false positive associations due to str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd19c36f98df4a617e2b25fdfedd99cf
https://doi.org/10.1038/ng1333
https://doi.org/10.1038/ng1333
Autor:
John M. Higgins, Nick Patterson, Stacey Gabriel, Stephen F. Schaffner, Richard H. Cooper, Daniel J. Richter, Pardis C. Sabeti, Dominic P. Kwiatkowski, Eric S. Lander, Sarah J. Campbell, David Reich, Hans Ackerman, Haninah Z P Levine, Jill Platko, Gavin J. McDonald, Ryk Ward, David Altshuler
Publikováno v:
Nature. 419:832-837
The ability to detect recent natural selection in the human population would have profound implications for the study of human history and for medicine. Here, we introduce a framework for detecting the genetic imprint of recent positive selection by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514e1577876a255228148a4869bd79ea
https://doi.org/10.1038/nature01140
https://doi.org/10.1038/nature01140
Autor:
Kristin G. Ardlie, Arti Tandon, David Reich, Nick Patterson, Christopher A. Haiman, Sean O. Henderson, Gavin J. McDonald, Brian E. Henderson, Rahul C. Deo
Publikováno v:
PLoS Genetics, Vol 3, Iss 11, p e196 (2007)
PLoS Genetics
PLoS Genetics
Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a large-scale admixture scan for ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ea7724b1500b76dfb05b58ba994f13
http://europepmc.org/articles/PMC2077893?pdf=render
http://europepmc.org/articles/PMC2077893?pdf=render
Autor:
Arti Tandon, Sue A. Ingles, Nick Patterson, Brian E. Henderson, Matthew L. Freedman, Alicja Waliszewska, David Altshuler, Laurence N. Kolonel, David Reich, Gavin J. McDonald, Julie Neubauer, Melissa A. Frasco, Loreall Pooler, Kristin G. Ardlie, Steven C. Greenway, Ingrid Oakley-Girvan, Loic Le Marchand, Simon Myers, Christine Schirmer, Malcolm C. Pike, Daniel O. Stram, Esther M. John, Alice S. Whittemore, Kathleen A. Cooney, Christopher A. Haiman, David T.W. Wong
Publikováno v:
Nature genetics. 39(5)
After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69a7e2cf9826c4dfdaa7b731043e9e4
https://pubmed.ncbi.nlm.nih.gov/17460686
https://pubmed.ncbi.nlm.nih.gov/17460686
Autor:
Robert E. Ferrell, Donglei Hu, Elad Ziv, Scott Huntsman, Vijaya Ramesh, Gavin J. McDonald, Rongling Li, Tamara B. Harris, Alicja Waliszewska, Alexander P. Reiner, Philip L. De Jager, Arti Tandon, Steve Cummings, Pui-Yan Kwok, David Reich, Elizabeth J. Rossin, Joseph M. Zmuda, Melissa Garcia, Ludmila Pawlikowska, Christina Wassel-Fyr, Bani Tamraz, Nick Patterson, Edwin Choy
Publikováno v:
American journal of human genetics. 80(4)
Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from the Health, Aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4ebb008939847077b96dce2ecf01fb
https://pubmed.ncbi.nlm.nih.gov/17357077
https://pubmed.ncbi.nlm.nih.gov/17357077
Autor:
David Reich, Gavin J. McDonald, Christopher A. Haiman, Robert G. Steen, Alice S. Whittemore, Matthew L. Freedman, Brian E. Henderson, David Altshuler, Kathleen A. Cooney, Kathryn L. Penney, Nick Patterson, Alicja Waliszewska, Ingrid Oakley-Girvan, Esther M. John, Kristin Ardlie, Sue A. Ingles, Arti Tandon
A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting Afri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a2852aabe24c69d13c198aabcc2fe9
https://europepmc.org/articles/PMC1599913/
https://europepmc.org/articles/PMC1599913/
