Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Gavin J, Knott"'
Autor:
Tricia L. Lo, Qi Wang, Joshua Nickson, Bryce J. W. van Denderen, Deanna Deveson Lucas, Her Xiang Chai, Gavin J. Knott, Harshini Weerasinghe, Ana Traven
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTFungal infections cause a large health burden but are treated by only a handful of antifungal drug classes. Chromatin factors have emerged as possible targets for new antifungals. These targets include the reader proteins, which interact with
Externí odkaz:
https://doaj.org/article/945ca35914bb41c18f1153b08f7b2e7d
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Short segments of RNA displace one strand of a DNA duplex during diverse processes including transcription and CRISPR-mediated immunity and genome editing. These strand exchange events involve the intersection of two geometrically distinct helix type
Externí odkaz:
https://doaj.org/article/3625d2d6aa4b4144bf2a4395e0f828fb
Autor:
Eric A. Nalefski, Nidhi Patel, Philip J.Y. Leung, Zeba Islam, Remy M. Kooistra, Ishira Parikh, Estelle Marion, Gavin J. Knott, Jennifer A. Doudna, Anne-Laure M. Le Ny, Damian Madan
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102996- (2021)
Summary: Bacterial CRISPR systems provide acquired immunity against invading nucleic acids by activating RNA-programmable RNases and DNases. Cas13a and Cas12a enzymes bound to CRISPR RNA (crRNA) recognize specific nucleic acid targets, initiating cle
Externí odkaz:
https://doaj.org/article/80d19e1840ea49a8a0286554c752aad5
Autor:
Gavin J Knott, Brady F Cress, Jun-Jie Liu, Brittney W Thornton, Rachel J Lew, Basem Al-Shayeb, Daniel J Rosenberg, Michal Hammel, Benjamin A Adler, Marco J Lobba, Michael Xu, Adam P Arkin, Christof Fellmann, Jennifer A Doudna
Publikováno v:
eLife, Vol 8 (2019)
CRISPR-Cas systems provide bacteria and archaea with programmable immunity against mobile genetic elements. Evolutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-CRISPRs (Acrs), that block Cas enzyme fu
Externí odkaz:
https://doaj.org/article/164dc30ebd294804bf4e661f484ab735
Publikováno v:
Nature Structural & Molecular Biology. 29:395-402
Autor:
Pei Wen Lee, Andrew C. Marshall, Gavin J. Knott, Simon Kobelke, Luciano Martelotto, Ellie Cho, Paul J. McMillan, Mihwa Lee, Charles S. Bond, Archa H. Fox
RNA-binding proteins of the DBHS (Drosophila Behavior Human Splicing) family, NONO, SFPQ, and PSPC1 have numerous roles in genome stability and transcriptional and posttranscriptional regulation. Critical to DBHS activity is their recruitment to dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97541b6e5d5dac1b84d5e27abd960068
Publikováno v:
Methods. 212:10-11
Autor:
Gavin J. Knott, Tiffany W. Lin, Ariel L. Furst, Wen Fu, Jing Dai, R. David Britt, Matthew B. Francis
Publikováno v:
ACS Nano. 15:8110-8119
Bioenergetic processes in nature have relied on networks of cofactors for harvesting, storing, and transforming the energy from sunlight into chemical bonds. Models mimicking the structural arrangement and functional crosstalk of the cofactor arrays
Publikováno v:
Nature structuralmolecular biology. 29(4)
In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9 searches millions of DNA base pairs to locate a 20-nucleotide, guide RNA-complementary target sequence that abuts a protospacer-adjacent motif (PAM). Target capt
Autor:
Audrone Lapinaite, Gavin J. Knott
Publikováno v:
Science
IscB proteins are putative nucleases encoded in a distinct family of IS200/IS605 transposons and are likely ancestors of the RNA-guided endonuclease Cas9, but the functions of IscB and its interactions with any RNA remain uncharacterized. Using evolu