Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Gavin J, Clowry"'
Publikováno v:
Frontiers in Dementia, Vol 3 (2024)
IntroductionNeuronal hyperexcitability and neuroinflammation are thought to occur at early stages in a range of neurodegenerative diseases. Neuroinflammation, notably activation of microglia, has been identified as a potential prodromal marker of dem
Externí odkaz:
https://doaj.org/article/3030d2f922534e369de89646a4b2567f
Autor:
Faye McLeod, Elaine McDermott, Shermin Mak, Darren Walsh, Mark Turnbull, Fiona E. N. LeBeau, Andrew Jackson, Andrew J. Trevelyan, Gavin J. Clowry
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionExpression of light sensitive ion channels by selected neurons has been achieved by viral mediated transduction with gene constructs, but for this to have therapeutic uses, for instance in treating epilepsy, any adverse effects of viral i
Externí odkaz:
https://doaj.org/article/a562754520e34887bbc3e3de81c84cc0
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionThe protein fasciculation and elongation zeta-1 (FEZ1) is involved in axon outgrowth but potentially interacts with various proteins with roles ranging from intracellular transport to transcription regulation. Gene association and other s
Externí odkaz:
https://doaj.org/article/49c2138a68d1493ca4083ce833a14667
Autor:
Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Piróg, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene t
Externí odkaz:
https://doaj.org/article/b74a1a1210eb465eb49f8ba80fb52c10
Autor:
Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randall, Daniel Erskine, Christopheer M. Morris, Amy K. Reeve, Gavin J. Clowry, Fiona E.N. LeBeau
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105226- (2021)
Abnormal excitability in cortical networks has been reported in patients and animal models of Alzheimer's disease (AD), and other neurodegenerative conditions. Whether hyperexcitability is a core feature of alpha(α)-synucleinopathies, including deme
Externí odkaz:
https://doaj.org/article/7cc70cc1dbc340cfbe1ea9fc7ebe075c
Autor:
Ayman Alzu’bi, Gavin J. Clowry
Publikováno v:
Frontiers in Neuroanatomy, Vol 14 (2020)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in
Externí odkaz:
https://doaj.org/article/547a541feabe48479b2552d92f4887e5
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Increasing evidence from animal and human studies indicate that exposure to nicotine during development, separated from the effects of smoking tobacco, can contribute to dysregulation of brain development including behavioral deficits. An RNAseq stud
Externí odkaz:
https://doaj.org/article/dbff4b62fa34452e9fa0b448b94361f6
Autor:
Ingrid Ehrmann, Matthew R. Gazzara, Vittoria Pagliarini, Caroline Dalgliesh, Mahsa Kheirollahi-Chadegani, Yaobo Xu, Eleonora Cesari, Marina Danilenko, Marie Maclennan, Kate Lowdon, Tanja Vogel, Piia Keskivali-Bond, Sara Wells, Heather Cater, Philippe Fort, Mauro Santibanez-Koref, Silvia Middei, Claudio Sette, Gavin J. Clowry, Yoseph Barash, Mark O. Cunningham, David J. Elliott
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3269-3280 (2016)
The brain is made up of trillions of synaptic connections that together form neural networks needed for normal brain function and behavior. SLM2 is a member of a conserved family of RNA binding proteins, including Sam68 and SLM1, that control splicin
Externí odkaz:
https://doaj.org/article/f0ae21a2845440f5b5bb4825a77a395e
Autor:
Faye McLeod, Anna Dimtsi, Amy C Marshall, David Lewis-Smith, Rhys Thomas, Gavin J Clowry, Andrew J Trevelyan
Publikováno v:
Brain : a journal of neurology.
Early infantile developmental and epileptic encephalopathies are devastating conditions, generally of genetic origin, but the pathological mechanisms often remain obscure. A major obstacle in this field of research is the difficulty of studying corti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b073d755e2d364585b63d5b76fdf0f
https://pubmed.ncbi.nlm.nih.gov/36315647
https://pubmed.ncbi.nlm.nih.gov/36315647
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165606 (2016)
Micromotion between the brain and implanted electrodes is a major contributor to the failure of invasive microelectrodes. Movements of the electrode tip cause recording instabilities while spike amplitudes decline over the weeks/months post-implantat
Externí odkaz:
https://doaj.org/article/ccb2bef5118e4e70874dc962086c1b15