Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Gavin Halbert"'
Publikováno v:
British Journal of Pharmacy, Vol 8, Iss 2 (2023)
This study applies biorelevant fasted and fed simulated intestinal media (SIM) to compare the solubility of griseofulvin, ibuprofen, and dipyridamole to investigate the prediction of food effects. These media cover over 90% of the human intestinal fl
Externí odkaz:
https://doaj.org/article/2ef5dcb97598413599690d9dde575cec
Publikováno v:
British Journal of Pharmacy, Vol 8, Iss 2 (2023)
Solubility and dynamic light scattering (DLS) studies of three poorly soluble drugs(naproxen, indomethacin and phenytoin) in simulated intestinal fluid (SIF) were carried out in order to calculate the number of drug molecules per micelle based on the
Externí odkaz:
https://doaj.org/article/a0765caf087d4022a272a9779cb4cefc
Publikováno v:
British Journal of Pharmacy, Vol 8, Iss 2 (2023)
The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro. In this study, 9-point bioequivalent sim
Externí odkaz:
https://doaj.org/article/6214516ed24d49f0bd8fe7ad609eda14
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Adequate drug solubility in the gastrointestinal tract is essential for systemic therapy of orally administered medications. To carry out research on the solubility of poorly soluble drugs in vitro, simulated intestinal fluid (SIF) is used in place o
Externí odkaz:
https://doaj.org/article/03da67d9720049f495eab7d814db8820
Autor:
Karim Osouli-Bostanabad, Sara Puliga, Dolores R. Serrano, Andrea Bucchi, Gavin Halbert, Aikaterini Lalatsa
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1940 (2022)
Nanoparticulate technologies have revolutionized drug delivery allowing for passive and active targeting, altered biodistribution, controlled drug release (temporospatial or triggered), enhanced stability, improved solubilization capacity, and a redu
Externí odkaz:
https://doaj.org/article/cf650d189bd74a10b74d2f59e3b25c84
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Purpose:AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT kinases. In preclinical models, AT13148 has been shown to have antimetastatic and antiproliferative activity.Patients and Methods:The trial followed a rolling six d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a333c1f82c5ff3931176d17bb6ff2c
https://doi.org/10.1158/1078-0432.c.6529065.v1
https://doi.org/10.1158/1078-0432.c.6529065.v1
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Inclusion/Exclusion Criteria and Pharmacokinetic Analytical Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5127ad704e76e04993609e6ace90960e
https://doi.org/10.1158/1078-0432.22475382
https://doi.org/10.1158/1078-0432.22475382
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Relationship between dose and AUC/Cmax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680ddacf31e0bd6d533d55ce226c23b9
https://doi.org/10.1158/1078-0432.22475379
https://doi.org/10.1158/1078-0432.22475379
Autor:
Erin Walsh, Natalie Maclean, Alice Turner, Moulham Alsuleman, Elke Prasad, Gavin Halbert, Joop H. ter Horst, Daniel Markl
Publikováno v:
International journal of pharmaceutics. 624
With advancements in the pharmaceutical industry pushing more towards tailored medicines, novel approaches to tablet manufacture are in high demand. One of the main drivers towards micro-scale batch production is the ability to fine-tune drug release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b009b895c3f2373fb60693b61cf4fb
https://pubmed.ncbi.nlm.nih.gov/35760259
https://pubmed.ncbi.nlm.nih.gov/35760259
Autor:
Hikaru G. Jolliffe, Ebenezer Ojo, Carlota Mendez, Ian Houson, Richard Elkes, Gavin Reynolds, Angela Kong, Elizabeth Meehan, Felipe Amado Becker, Patrick M. Piccione, Sudhir Verma, Aditya Singaraju, Gavin Halbert, John Robertson
Publikováno v:
International journal of pharmaceutics. 626
Recent years have seen the advent of Quality-by-Design (QbD) as a philosophy to ensure the quality, safety, and efficiency of pharmaceutical production. The key pharmaceutical processing methodology of Direct Compression to produce tablets is also th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe40c39add24ce10af3380286cffae4
https://pubmed.ncbi.nlm.nih.gov/35987318
https://pubmed.ncbi.nlm.nih.gov/35987318