Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Gavin F, Painter"'
Autor:
Anna H. Mooney, Sarah L. Draper, Olivia K. Burn, Regan J. Anderson, Benjamin J. Compton, Chingwen Tang, Kathryn J. Farrand, Pietro Di Lucia, Micol Ravà, Valeria Fumagalli, Leonardo Giustini, Elisa Bono, Dale I. Godfrey, William R. Heath, Weiming Yuan, Francis V. Chisari, Luca G. Guidotti, Matteo Iannacone, John Sidney, Alessandro Sette, Shivali A. Gulab, Gavin F. Painter, Ian F. Hermans
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101038- (2024)
Background & Aims: Liver diseases resulting from chronic HBV infection are a significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of controlling the virus represent a treatment strategy with potential for long-t
Externí odkaz:
https://doaj.org/article/ee2629abc47b4a819f89b5234ea4bfff
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 3, Pp 241-245 (2023)
The racemic title compound, C34H32OS2, comprises an atropisomeric binaphthyl dithioacetal substituted at the methylene carbon atom with a chiral benzyl alcohol. The two naphthalene ring systems are additionally substituted at the 3,3′-position with
Externí odkaz:
https://doaj.org/article/480cf673a97c445199aa56fb9036f173
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 2, Pp 107-111 (2023)
The closely related title compounds, 1-(dinaphtho[2,1-d:1′,2′-f][1,3]dithiepin-4-yl)-2,2-dimethylpropan-1-ol, C26H24OS2, 1 and 2-(dinaphtho[2,1-d:1′,2′-f][1,3]dithiepin-4-yl)-3,3-dimethylbutan-2-ol, C27H26OS2, 2, both comprise an atropisomeri
Externí odkaz:
https://doaj.org/article/2fcb65b4d49644ff9afe1bbe4a69a5ae
Autor:
Theresa E. Pankhurst, Kaitlin H. Buick, Joshua L. Lange, Andrew J. Marshall, Kaileen R. Button, Olga R. Palmer, Kathryn J. Farrand, Isabelle Montgomerie, Thomas W. Bird, Ngarangi C. Mason, Joanna Kuang, Benjamin J. Compton, Davide Comoletti, Mariolina Salio, Vincenzo Cerundolo, Miguel E. Quiñones-Mateu, Gavin F. Painter, Ian F. Hermans, Lisa M. Connor
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112310- (2023)
Summary: Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered
Externí odkaz:
https://doaj.org/article/a3b5f150bb494cd2ab24b2e9cd902159
Autor:
Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter, Ian F Hermans
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural
Externí odkaz:
https://doaj.org/article/423fa268183140eca4c64e8a2ff85aed
Autor:
Olivia K Burn, Kathryn Farrand, Tara Pritchard, Sarah Draper, Ching‐wen Tang, Anna H Mooney, Alfonso J Schmidt, Sung H Yang, Geoffrey M Williams, Margaret A Brimble, Matheswaran Kandasamy, Andrew J Marshall, Kate Clarke, Gavin F Painter, Ian F Hermans, Robert Weinkove
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Objectives Metastasis is the principal cause of breast cancer mortality. Vaccines targeting breast cancer antigens have yet to demonstrate clinical efficacy, and there remains an unmet need for safe and effective treatment to reduce the risk
Externí odkaz:
https://doaj.org/article/3c9b77a20a6e4b3da7b8452985eb9f84
Autor:
Ellie-May Jarvis, Shaun Collings, Astrid Authier-Hall, Nathaniel Dasyam, Brendan Luey, John Nacey, Gavin F. Painter, Brett Delahunt, Ian F. Hermans, Robert Weinkove
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Prostate cancer is the second most common cancer in men worldwide. Despite an abundance of prostate-specific antigens, immunotherapies have yet to become a standard of care, potentially limited by T-cell dysfunction. Up to 10% of human circulating T-
Externí odkaz:
https://doaj.org/article/d726908ea6fa4815a7d301e76cd6be96
Publikováno v:
Data in Brief, Vol 35, Iss , Pp 106883- (2021)
Cytosine-phosphate-guanine (CpG) oligonucleotides are commonly-used vaccine adjuvants to promote the activation of antigen-presenting cells (APCs). To mount an effective immune response, CpG needs to be internalized and bind to its endosomal Toll-lik
Externí odkaz:
https://doaj.org/article/25e7b5580e8c48c28793ea554680b257
Autor:
Yanyan Li, Katherine Woods, Amber Parry-Strong, Regan J. Anderson, Celina Capistrano, Aurelie Gestin, Gavin F. Painter, Ian F. Hermans, Jeremy Krebs, Olivier Gasser
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing c
Externí odkaz:
https://doaj.org/article/f7bea488c2e14977bbb50c30193e257e
Autor:
Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J. Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J. Compton, Susanna L. Cardell, Steven A. Porcelli, Gavin F. Painter, Dirk M. Zajonc, Jay A. Berzofsky, Masaki Terabe
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and p
Externí odkaz:
https://doaj.org/article/e95ec8af4f7c4721ac18347afdd733cc