Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gavin E. Murphy"'
Autor:
Gavin E. Murphy, Grant J. Jensen
Publikováno v:
BioTechniques, Vol 43, Iss 4, Pp 413-421 (2007)
Electron cryotomography is an emerging technique that allows the structures of unique biological objects such as individual macromolecules, viruses, and even small whole cells to be reconstructed in their near-native states in three dimensions (3-D)
Externí odkaz:
https://doaj.org/article/95e3a02609a94a019e63f1ee523ebbd3
Autor:
Kedar Narayan, Edward M Perkins, Gavin E Murphy, Sarat K Dalai, Michael Edidin, Sriram Subramaniam, Scheherazade Sadegh-Nasseri
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6188 (2009)
The superantigen SEA causes non-specific hyperactivation of T and B cells at low concentrations. Studies of mutants or soluble proteins suggest SEA is bivalent for its ligand, MHC class II. However, the interaction between these molecules on intact c
Externí odkaz:
https://doaj.org/article/9e3067f0364440ef921948f6ea68e856
Autor:
Morgan Beeby, Ariane Briegel, Axel Müller, Grant J. Jensen, Megan J. Dobro, Zhuo Li, Gavin E. Murphy, Songye Chen, Jared R. Leadbetter, David R. Hendrixson, Elitza I. Tocheva, Jian Shi
Publikováno v:
The EMBO Journal. 30:2972-2981
The bacterial flagellum is one of nature's most amazing and well-studied nanomachines. Its cell-wall-anchored motor uses chemical energy to rotate a microns-long filament and propel the bacterium towards nutrients and away from toxins. While much is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9d90e989ae69687dd1bfc25ce5eadf
https://doi.org/10.1038/emboj.2011.186
https://doi.org/10.1038/emboj.2011.186
Autor:
Cristina V. Iancu, Ariane Briegel, William F. Tivol, Elizabeth R. Wright, Zhiheng Yu, Lu Gan, D. Prabha Dias, Grant J. Jensen, Jordan B Schooler, Zhuo Li, Gregory P. Henderson, Gavin E. Murphy, Yongning He
Publikováno v:
Nature Protocols. 1:2813-2819
Electron cryotomography is the highest-resolution structural technique currently available that can be applied to unique objects such as flexible large protein complexes, irregular viruses, organelles and small cells. Specimens are preserved in a nea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9df129b2fc058c400647fe85c7dd9d2
https://doi.org/10.1038/nprot.2006.432
https://doi.org/10.1038/nprot.2006.432
Autor:
Gavin E. Murphy, Grant J. Jensen
Publikováno v:
Structure. 13:1765-1773
The E. coli pyruvate and 2-oxoglutarate dehydrogenases are two closely related, large complexes that exemplify a growing number of multiprotein "machines" whose domains have been studied extensively and modeled in atomic detail, but whose quaternary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c862857bfd273b907e6de18473fd9935
https://doi.org/10.1016/j.str.2005.08.016
https://doi.org/10.1016/j.str.2005.08.016
Autor:
Gavin E. Murphy, Matthias Wilmanns, Peijian Zou, Francisco J. Fernández, Reinhard Sterner, Alexander Popov, M. Cristina Vega
Publikováno v:
Molecular Microbiology. 55:675-686
The molecular structure of the ATP phosphoribosyl transferase from the hyperthermophile Thermotoga maritima is composed of a 220 kDa hetero-octameric complex comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ). Steady-state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::652c01f44292901d36d554fba6bdd8c7
https://doi.org/10.1111/j.1365-2958.2004.04422.x
https://doi.org/10.1111/j.1365-2958.2004.04422.x
Autor:
Sriram Subramaniam, Lesley A. Earl, Gavin E. Murphy, Gregory Q. Del Prete, Prashant Rao, Donald Bliss, Jeffrey D. Lifson, Guan Han Li, Avindra Nath, James A. Thomas, Thao Do, Giovanna Grandinetti, Jeff Spector, Charles M. Trubey, Jacob D. Estes
HIV transmission efficiency is greatly increased when viruses are transmitted at virological synapses formed between infected and uninfected cells. We have previously shown that virological synapses formed between HIV-pulsed mature dendritic cells (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cd68b30f7a7049da284911470e8167
https://europepmc.org/articles/PMC4178837/
https://europepmc.org/articles/PMC4178837/
Publikováno v:
Biochemistry. 40:13230-13236
Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate dependent enzyme that catalyzes the first committed step in the biosynthesis of polyamines. ODC is a proven drug target for the treatment of African sleeping sickness. The enzyme is an obligat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4930c9f67a9b9784adc78fe19b36d3
https://doi.org/10.1021/bi0155908
https://doi.org/10.1021/bi0155908
Autor:
Gavin E. Murphy, Lisa M. Hartnell, Bradley C. Lowekamp, Sriram Subramaniam, Jurgen Heymann, Jing Fu, Kedar Narayan
We report methodological advances that extend the current capabilities of ion-abrasion scanning electron microscopy (IA–SEM), also known as focused ion beam scanning electron microscopy, a newly emerging technology for high resolution imaging of la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4856fe582cde91a88f3ace642d2157
https://europepmc.org/articles/PMC3210386/
https://europepmc.org/articles/PMC3210386/
Autor:
Gavin E. Murphy, Patricia M. Zerfas, Randy J. Chandler, Charles P. Venditti, Bradley C. Lowekamp, Sriram Subramaniam, Rajesh Narasimha
Methylmalonic acidemia is a lethal inborn error of metabolism that causes mitochondrial impairment, multi-organ dysfunction and a shortened lifespan. Previous transmission electron microscope studies of thin sections from normal (Mut(+/+)) and diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb4352285103f778704ab7866a222bf
https://europepmc.org/articles/PMC2885563/
https://europepmc.org/articles/PMC2885563/