Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gavin Donoghue"'
Autor:
Donna S. Macmillan, Doreen A.T. Sekibo, Carol Clements, Keith R. Fox, David Breen, Abedawn I. Khalaf, Gavin Donoghue, Claire Bourdin, Fraser J. Scott, Colin J. Suckling
Publikováno v:
European Journal of Medicinal Chemistry. 56:39-47
The design and synthesis of a new class of minor groove binder (MGBs) in which, the cationic tail group has been replaced by a neutral, polar variant including cyanoguanidine, nitroalkene, and trifluoroacetamide groups. Antibacterial activity (agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468d04cd172a8b3ab9aa1d82e3f67bd3
https://doi.org/10.1016/j.ejmech.2012.08.013
https://doi.org/10.1016/j.ejmech.2012.08.013
Autor:
Nahoum G. Anthony, Abedawn I. Khalaf, Fraser J. Scott, Colin J. Suckling, David Breen, Simon P. Mackay, Gavin Donoghue
Publikováno v:
European journal of medicinal chemistry. 46(11)
Antibacterial minor groove binders related to the natural product, distamycin, are development candidates for novel antibiotics. Alkenes have been found to be effective substitutes for the isosteric amide links in some positions and alkyl groups larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6bee1c9f59bcaad68ed35b2ca3f4fb
https://pubmed.ncbi.nlm.nih.gov/21908079
https://pubmed.ncbi.nlm.nih.gov/21908079
Autor:
Colin J. Suckling, David Breen, Abedawn I. Khalaf, John Parkinson, Simon P. Mackay, Gavin Donoghue, Nahoum G. Anthony
Publikováno v:
Organicbiomolecular chemistry. 7(9)
A practical synthesis of alkene-containing minor-groove binders for DNA, related to distamycin, with potential for wide structural diversity is described, based upon the Wittig chemistry of N-alkylpyrrole aldehydes. The compounds prepared have been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64da61b0a6aacb12c2cf690bc9b06acc
https://pubmed.ncbi.nlm.nih.gov/19590779
https://pubmed.ncbi.nlm.nih.gov/19590779
Autor:
Elizabeth M. Ellis, Iain S. Hunter, Gavin Donoghue, Curtis G. Gemmell, Nahoum G. Anthony, Jean-Jacques Helesbeux, Joanna Clarke, John Parkinson, Simon P. Mackay, Colin J. Suckling, David Breen, Abedawn I. Khalaf, Allan J. Drummond, Roger D. Waigh
Publikováno v:
Journal of medicinal chemistry. 50(24)
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotropsins are described. The design of the compounds was principally predicated upon increased affinity arising from hydrophobic interactions between min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a3cdef5dcafdd56d437c52f4cdba00
https://pubmed.ncbi.nlm.nih.gov/17960927
https://pubmed.ncbi.nlm.nih.gov/17960927
Autor:
Nahoum G. Anthony, David Breen, Joanna Clarke, Gavin Donoghue, Allan J. Drummond, Elizabeth M. Ellis, Curtis G. Gemmell, Jean-Jacques Helesbeux, Iain S. Hunter, Abedawn I. Khalaf, Simon P. Mackay, John A. Parkinson, Colin J. Suckling, Roger D. Waigh
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 24, p6116-6125, 10p