Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Gavin C Higgins"'
1
Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy
Autor: Matthew Snelson, Sih Min Tan, Runa S.J. Lindblom, Gavin C Higgins, Melinda T. Coughlan
Publikováno v: American Journal of Physiology-Renal Physiology. 318:F835-F842
Alterations in gut homeostasis may contribute to the progression of diabetic nephropathy. There has been recent attention on the renoprotective effects of metabolite-sensing receptors in chronic renal injury, including the G-protein-coupled-receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0832aaefa5a8e209f6b141f246d2cf
https://doi.org/10.1152/ajprenal.00505.2019
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2
Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D
Autor: Maryann Arnstein, Melinda T. Coughlan, Cesare Granata, Runa S.J. Lindblom, Josephine M. Forbes, Mark E. Cooper, Darren C. Henstridge, Matthew Snelson, Vicki Thallas-Bonke, Tuong-Vi Nguyen, Gavin C Higgins
Publikováno v: Clinical Science. 134:239-259
Mitochondrial stress has been widely observed in diabetic kidney disease (DKD). Cyclophilin D (CypD) is a functional component of the mitochondrial permeability transition pore (mPTP) which allows the exchange of ions and solutes between the mitochon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d439367927952f4a1fdfe35364abbf
https://doi.org/10.1042/cs20190787
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3
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart
Autor: Rebecca H. Ritchie, Thomas Krieg, Runa S.J. Lindblom, Helen Kiriazis, Mitchel Tate, Richard C. Hartley, Melinda T. Coughlan, Miles J. De Blasio, Stuart T. Caldwell, Michael P. Murphy, Minh Deo, Gavin C Higgins, Darnel Prakoso, Min Park, Carlos D. Baeza-Garza
Publikováno v: Cardiovascular Drugs and Therapy
Cardiovasc Drugs Ther
Purpose Methylglyoxal, a by-product of glycolysis and a precursor in the formation of advanced glycation end-products, is significantly elevated in the diabetic myocardium. Therefore, we sought to investigate the mitochondria-targeted methylglyoxal s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa21a4ded8bf464bdea78cb55472c85
http://europepmc.org/articles/PMC6994445
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4
Methods in renal research: Measurement of autophagic flux in the renal cortex ex vivo
Autor: Georg Ramm, Gavin C Higgins, Tuong-Vi Nguyen, Melinda T. Coughlan
Publikováno v: Nephrology. 23:815-820
The role of autophagy in the kidney and many nephrological diseases has gained prominence in recent years. Much of this research has been focused on markers of autophagy that are static and reveal little about the state of this dynamic pathway. Other
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df1b3910d4a0fea2e1386d986dacbc
https://doi.org/10.1111/nep.13251
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6
Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes
Autor: Mark E. Cooper, Brooke E. Harcourt, Vicki Thallas-Bonke, Karly C. Sourris, Sally A. Penfold, Nicole J Van Bergen, Josephine M. Forbes, Sih Min Tan, Melinda T. Coughlan, Gavin C Higgins, David R. Thorburn, Ian A. Trounce, Tuong-Vi Nguyen
Publikováno v: Clinical Science. 130:711-720
Oxidative phosphorylation (OXPHOS) drives ATP production by mitochondria, which are dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In diabetic kidney disease (DKD), mitochondria appear dysfunctional, but the tempo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb713c0ef237d1d7d5eb9034bb587cf
https://doi.org/10.1042/cs20150838
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7
Mitochondrial Fission/Fusion and Disease
Autor: Gavin C Higgins, Melinda T. Coughlan
Publikováno v: eLS
The mitochondria are a multifaceted organelle, central to the function of all eukaryotic cells. Mitochondria are critical to cell metabolism and critical for regulation of intrinsic cell death pathways. This balance between life and death is reliant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e36b12dc57fb9b45d19cac6bcb7e495
https://doi.org/10.1002/9780470015902.a0021879
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8
TheStk35locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress
Autor: Chin Wong, Penny A. F. Whiley, Kate L Loveland, Taro Tachibana, Gavin C Higgins, Yoichi Miyamoto, Hoey Y. Goh, Paul G. McMenamin, Lynne Mayne
Publikováno v: Biology Open
Biology Open, Vol 7, Iss 8 (2018)
Serine/threonine kinase 35 (STK35) is a recently identified human kinase with an autophosphorylation function, linked functionally to actin stress fibers, cell cycle progression and survival. STK35 has previously been shown to be highly expressed in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cfa06eebf18afc8052f32f333c3035
https://doi.org/10.1242/bio.032631
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10
MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology
Autor: Andrew J Lawrence, Philip M Beart, Chew L. Lau, Gavin C Higgins, Linda D Mercer
Publikováno v: Neurochemistry international. 105
Toxicity of 3,4-methylenedioxymethamphetamine (MDMA) towards biogenic amine neurons is well documented and in primate brain predominantly affects serotonin (5-HT) neurons. MDMA induces damage of 5-HT axons and nerve fibres and intracytoplasmic inclus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dd261748e3f3794a38a7a43e698f32
https://pubmed.ncbi.nlm.nih.gov/28122248
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