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pro vyhledávání: '"Gavin A.C. Chung"'
Autor:
Gavin A.C. Chung, Paul W. Smith, Mike R. Wood, Ken Duncan, Albert Jaxa Chamiec, Peter D. Howes, Andrew R. Whittington, Kevin N. Cobley
Publikováno v:
The Journal of Antibiotics. 48:73-82
A series of cephalosporins containing a novel 7-[2-(Z)-(2-amino-thiazol-4- yl)-3-(dimethoxy-phosphoryl)-acryloylamino] group were prepared and their antibacterial activity measured against a range of pathogens. In general the compounds displayed a br
Autor:
Kevin N. Cobley, M. R. Wood, Peter David Howes, P.W. Smith, Andrew R. Whittington, Gavin A.C. Chung, A. Jaxa Chamiec, Ken Duncan
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 38
Autor:
Gavin A.C. Chung, Michael Oshin, Michael D. Wall, Tony Parkhouse, Alfonso Mendoza, Ken Duncan, Martin J. Everett, Brian Cox, Andrea Gore, Brian Evans, Esperanza Herreros
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(10)
The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluat
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(6)
The multiple parallel synthesis of a series of N,S-bis-alkylated thiopyrazolo[3,4-d]pyrimidines, based on sequential S- then N-alkylation, is reported. These compounds showed significant anti-mycobacterial activity (MICs down to 2mug/ml) and their po