Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Gavin A. Bewick"'
Autor:
Tatiana Lopes, David CD. Hope, Jose M. Ramos-Pittol, Anna Curtis, Jed V. Shrewsbury, Iona Davies, Zijing Zhou, Alessandro Sardini, James S. Minnion, Dirk Dormann, Gavin A. Bewick, Kevin G. Murphy, David Carling, Stephen R. Bloom, Tricia MM. Tan, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102024- (2024)
Objective: Glucagon has long been proposed as a component of multi-agonist obesity therapeutics due to its ability to induce energy expenditure and cause weight loss. However, chronic glucagon-receptor agonism has been associated with a reduction in
Externí odkaz:
https://doaj.org/article/d0ac3e309a1b4c52b8fc5d7efd834e06
Autor:
Xiuchuan (Lucas) Hu, Wenfeng Xiao, Yuxian Lei, Adam Green, Xinyi Lee, Muralidhara Rao Maradana, Yajing Gao, Xueru Xie, Rui Wang, George Chennell, M. Albert Basson, Pete Kille, Wolfgang Maret, Gavin A. Bewick, Yufeng Zhou, Christer Hogstrand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components affecting intestinal epithelial barrier function. Here, we explore whether zinc and the AHR pathway are linked. We show that dietary supplementation
Externí odkaz:
https://doaj.org/article/293292421854444796bd4bce0b9a0f58
Autor:
Anastasia Tsakmaki, Patricia Fonseca Pedro, Polychronis Pavlidis, Bu’Hussain Hayee, Gavin A. Bewick
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 157-173 (2020)
Objective: Enteroendocrine cells (EECs) survey the gut luminal environment and coordinate hormonal, immune and neuronal responses to it. They exhibit well-characterised physiological roles ranging from the control of local gut function to whole body
Externí odkaz:
https://doaj.org/article/4656a5e9d0ea43fb83f4f718ef57930f
Autor:
Ajeet P. Singh, Yu-Han Hung, Michael T. Shanahan, Matt Kanke, Alessandro Bonfini, Michael K. Dame, Mandy Biraud, Bailey C.E. Peck, Oyebola O. Oyesola, John M. Freund, Rebecca L. Cubitt, Ennessa G. Curry, Liara M. Gonzalez, Gavin A. Bewick, Elia D. Tait-Wojno, Natasza A. Kurpios, Shengli Ding, Jason R. Spence, Christopher M. Dekaney, Nicolas Buchon, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 447-464 (2020)
Background & Aims: The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to intestinal epithelial growth and renewal, but the underlying mechanisms remain poorly understo
Externí odkaz:
https://doaj.org/article/e87a118dfef14cd1be95f0a2ba116a82
Autor:
Lucy Brooks, Alexander Viardot, Anastasia Tsakmaki, Emilie Stolarczyk, Jane K. Howard, Patrice D. Cani, Amandine Everard, Michelle L. Sleeth, Arianna Psichas, Jelena Anastasovskaj, Jimmy D. Bell, Kim Bell-Anderson, Charles R. Mackay, Mohammad A. Ghatei, Stephen R. Bloom, Gary Frost, Gavin A. Bewick
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 48-60 (2017)
Objective: Dietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free fatty acid receptor 2 (FFAR2). Our aim was to test the
Externí odkaz:
https://doaj.org/article/6e138d5bb03648ce81d279034f1eb881
Autor:
Eduardo G. H. de Moura, Alberto M. Ponte-Neto, Anastasia Tsakmaki, Vera Demarchi Aiello, Gavin A. Bewick, Vitor O. Brunaldi
Publikováno v:
Endoscopy International Open, Vol 07, Iss 05, Pp E685-E690 (2019)
Background and study aims Minimally invasive procedures that replicate aspects of bariatric surgery with more favorable safety and tolerability offer an attractive alternative in management of metabolic disease. Duodenal mucosal resurfacing (DMR), an
Externí odkaz:
https://doaj.org/article/4bb209e577cd40298e605d7d6c5ba0d5
Autor:
Luis Fernando Delgadillo-Silva, Anastasia Tsakmaki, Nadeem Akhtar, Zara J. Franklin, Judith Konantz, Gavin A. Bewick, Nikolay Ninov
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 1 (2019)
Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap require
Externí odkaz:
https://doaj.org/article/7f5ba0f044434aa0811b586038338678
Autor:
Jason A West, Anastasia Tsakmaki, Soumitra S Ghosh, David G Parkes, Rikke V Grønlund, Philip J Pedersen, David Maggs, Harith Rajagopalan, Gavin A Bewick
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249239 (2021)
Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine the established benefits of glucagon-like peptide-1 (GLP-1) agonism with one or more addition
Externí odkaz:
https://doaj.org/article/0d79c9bba3884a64acb17d2b7e8c1e7b
Autor:
Xiuchuan Hu, Wenfeng Xiao, Yuxian Lei, Adam Green, Xinyi Lee, Muralidhara Rao Maradana, Yajing Gao, Xueru Xie, Rui Wang, George Chennell, M. Albert Basson, Pete Kille, Wolfgang Maret, Gavin A. Bewick, Yufeng Zhou, Christer Hogstrand
Both zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components which regulate intestinal epithelial barrier function and protect against Inflammatory Bowel Disease (IBD)1,2. Here, we explore whether zinc and AHR pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21bc3be268df5cff9668cd00548fe4cb
https://doi.org/10.1101/2022.11.03.515052
https://doi.org/10.1101/2022.11.03.515052
Autor:
Margot Jacobs, Gavin A. Bewick
Publikováno v:
The Biochemist. 43:10-14
The gut is famously known for its function in food digestion and absorption, but what if we told you that it is also involved in diseases like diabetes? Diabetes is a metabolic disease, which affects over 460 million adults worldwide, where the body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e188d447b70e227c56bd20c0d693b34
https://doi.org/10.1042/bio_2021_111
https://doi.org/10.1042/bio_2021_111