Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Gavin, Rumbaugh"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S76-S77 (2023)
Externí odkaz:
https://doaj.org/article/2d67951efd844f2e9107ea5a59d3ab99
Autor:
Murat Kilinc, Vineet Arora, Thomas K Creson, Camilo Rojas, Aliza A Le, Julie Lauterborn, Brent Wilkinson, Nicolas Hartel, Nicholas Graham, Adrian Reich, Gemma Gou, Yoichi Araki, Àlex Bayés, Marcelo Coba, Gary Lynch, Courtney A Miller, Gavin Rumbaugh
Publikováno v:
eLife, Vol 11 (2022)
Loss-of-function variants in SYNGAP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple cellul
Externí odkaz:
https://doaj.org/article/b2d529b24e8e40d98531dc9a6b1666ca
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 10, Iss 1, Pp 1-6 (2018)
Abstract Background Pathologic mutations in SYNGAP1 cause a genetically defined form of intellectual disability (ID) with comorbid epilepsy and autistic features. While only recently discovered, pathogenicity of this gene is a relatively frequent gen
Externí odkaz:
https://doaj.org/article/6e6c0f1a07b9433c8fa208898f8060ef
Autor:
Thomas K Creson, Camilo Rojas, Ernie Hwaun, Thomas Vaissiere, Murat Kilinc, Andres Jimenez-Gomez, Jimmy Lloyd Holder Jr, Jianrong Tang, Laura L Colgin, Courtney A Miller, Gavin Rumbaugh
Publikováno v:
eLife, Vol 8 (2019)
It remains unclear to what extent neurodevelopmental disorder (NDD) risk genes retain functions into adulthood and how they may influence disease phenotypes. SYNGAP1 haploinsufficiency causes a severe NDD defined by autistic traits, cognitive impairm
Externí odkaz:
https://doaj.org/article/10c02d4e26fb45a18f6fa15636bfbc56
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209846 (2019)
Stress profoundly impacts the brain and increases the risk of developing a psychiatric disorder. The brain's response to stress is mediated by a number of pathways that affect gene expression and protein function throughout the cell. Understanding ho
Externí odkaz:
https://doaj.org/article/bad06c96e37448b4ab4eded749017f9a
Autor:
Madalyn Hafenbreidel, Sherri B. Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B. Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D. Cameron, Gavin Rumbaugh, Courtney A. Miller
Publikováno v:
bioRxiv
Inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffeb6cb1607e007ee16afb0013ec6c45
https://europepmc.org/articles/PMC10245849/
https://europepmc.org/articles/PMC10245849/
Autor:
Vineet Arora, Sheldon Michaelson, Massimiliano Aceti, Murat Kilinic, Courtney Miller, Gavin Rumbaugh
SummaryGene expression intersects with neural activity to produce cortical circuits during brain development. However, the cell biological mechanisms linking gene expression to activity-dependent cortical circuit assembly remain unclear. Here, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85682d01cdb4063deebd3121d6220b69
https://doi.org/10.1101/2022.12.06.519295
https://doi.org/10.1101/2022.12.06.519295
Autor:
Adrian Reich, Courtney A. Miller, Vineet Arora, Gavin Rumbaugh, BanuPriya Sridharan, Murat Kilinc, J. Lloyd Holder, Lukasz Bijoch, Nerea Llamosas, David R. Piper, Louis Scampavia, Camilo Rojas, Timothy P. Spicer, Erik Willems, Ridhima Vij
Publikováno v:
J Neurosci
SYNGAP1is a major genetic risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy.De novoloss-of-function variants in this gene cause a neurodevelopmental disorder defined by cognitive impairment, social-com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf22e6ca5215ce4ed1bf45542dad19c
https://doi.org/10.1523/jneurosci.1367-20.2020
https://doi.org/10.1523/jneurosci.1367-20.2020
Autor:
Jos C. S. Kleinjans, Meghan E. Jones, Marco P. Boks, Kerry J. Ressler, Eric Vermetten, Courtney A. Miller, Julian Krauskopf, Torsten Klengel, Laurence de Nijs, Christiaan H. Vinkers, Sarah E. Jamieson, Nadine F. Joseph, Gavin Rumbaugh, Stephanie E. Sillivan, Elbert Geuze, Clara Snijders, Sabina Berretta, Bart P. F. Rutten
Publikováno v:
Molecular Psychiatry, 25(5), 965-976. Nature Publishing Group
Sillivan, S E, Jamieson, S, de Nijs, L, Jones, M, Snijders, C, Klengel, T, Joseph, N F, Krauskopf, J, Kleinjans, J, Vinkers, C H, Boks, M P M, Geuze, E, Vermetten, E, Berretta, S, Ressler, K J, Rutten, B P F, Rumbaugh, G & Miller, C A 2020, ' MicroRNA regulation of persistent stress-enhanced memory ', Molecular Psychiatry, vol. 25, no. 5, pp. 965-976 . https://doi.org/10.1038/s41380-019-0432-2
Molecular Psychiatry, 25(5), 965-976. NATURE PUBLISHING GROUP
Web of Science
Molecular psychiatry
Sillivan, S E, Jamieson, S, de Nijs, L, Jones, M, Snijders, C, Klengel, T, Joseph, N F, Krauskopf, J, Kleinjans, J, Vinkers, C H, Boks, M P M, Geuze, E, Vermetten, E, Berretta, S, Ressler, K J, Rutten, B P F, Rumbaugh, G & Miller, C A 2020, ' MicroRNA regulation of persistent stress-enhanced memory ', Molecular Psychiatry, vol. 25, no. 5, pp. 965-976 . https://doi.org/10.1038/s41380-019-0432-2
Molecular Psychiatry, 25(5), 965-976. NATURE PUBLISHING GROUP
Web of Science
Molecular psychiatry
Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously developed a stress-enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0140082d080190a870a3057b696c6ea
https://doi.org/10.1038/s41380-019-0432-2
https://doi.org/10.1038/s41380-019-0432-2