Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Gavin, Kelly"'
Autor:
Benjamin E. Clarke, Oliver J. Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Pierre Klein, Claudia A. Smith, Cameron A. Hall, Adel Helmy, Michael Howell, Gavin Kelly, Rickie Patani
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the role of microglia in ALS/FTD remains
Externí odkaz:
https://doaj.org/article/acbbd24c34554581a80b02dc7f9cfef6
Autor:
Cedric C. S. Tan, Gavin Kelly, Jack Cregan, Joseph D. Wilson, Tim James, Meera Chand, Susan Hopkins, Maaike Swets, J. Kenneth Baillie, Katie Jeffery, Ann Sarah Walker, David W. Eyre, Nicole Stoesser, Philippa C. Matthews
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background An outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children during 2022 was subsequently linked to infections with adenovirus-associated virus 2 and other ‘helper viruses’, including human adenovirus. It
Externí odkaz:
https://doaj.org/article/51ff2864dce64fd58480f6e6f3af61f9
Autor:
Rebecca A. Jones, Fay Cooper, Gavin Kelly, David Barry, Matthew J. Renshaw, Gopal Sapkota, James C. Smith
Publikováno v:
Open Biology, Vol 14, Iss 10 (2024)
The FAM83 (Family with sequence similarity 83) family is highly conserved in vertebrates, but little is known of the functions of these proteins beyond their association with oncogenesis. Of the family, FAM83F is of particular interest because it is
Externí odkaz:
https://doaj.org/article/bc04ce6418cf4df5af59631fe43fd62d
Autor:
Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here
Externí odkaz:
https://doaj.org/article/a58c4b29e1d8491b8078212067633916
Autor:
Hermaleigh Townsley, Joshua Gahir, Timothy W Russell, David Greenwood, Edward J Carr, Matala Dyke, Lorin Adams, Murad Miah, Bobbi Clayton, Callie Smith, Mauro Miranda, Harriet V Mears, Chris Bailey, James R M Black, Ashley S Fowler, Margaret Crawford, Katalin Wilkinson, Matthew Hutchinson, Ruth Harvey, Nicola O'Reilly, Gavin Kelly, Robert Goldstone, Rupert Beale, Padmasayee Papineni, Tumena Corrah, Richard Gilson, Simon Caidan, Jerome Nicod, Steve Gamblin, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Adam J Kucharski, Charles Swanton, David L V Bauer, Emma C Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0294897 (2024)
BackgroundSARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise symptoms and viral loads over the course of COVID-19 infection with these sub-varian
Externí odkaz:
https://doaj.org/article/95e0348e63df41608cfccc1b745cbb54
Autor:
Oliver J. Ziff, Jacob Neeves, Jamie Mitchell, Giulia Tyzack, Carlos Martinez-Ruiz, Raphaelle Luisier, Anob M. Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J. Boulton, Ammar Al-Chalabi, Gavin Kelly, Jack Humphrey, Rickie Patani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human i
Externí odkaz:
https://doaj.org/article/dd8f26a91a1646ca8fb84eb2c02762b3
Autor:
Phillip M. Brailey, Lauren Evans, Juan Carlos López-Rodríguez, Anthony Sinadinos, Victoria Tyrrel, Gavin Kelly, Valerie O’Donnell, Peter Ghazal, Susan John, Patricia Barral
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Modulation of metabolic pathways is linked to regulation of immune cells including macrophages. Here the authors identify a role for CD1d in the metabolic rewiring of macrophages, which alters responsiveness to innate stimuli.
Externí odkaz:
https://doaj.org/article/7fbedabfbd094fb7873e3dad81a05d67
Autor:
Gavin Kelly
Publikováno v:
Translation, Vol 11, Iss 1 (2023)
Please view the PDF to see the formatted meeting abstract.
Externí odkaz:
https://doaj.org/article/e9cd8e7d0f6f46bb9451ceb0d7dd9204
Autor:
Ambra Natalini, Sonia Simonetti, Gabriele Favaretto, Lorenzo Lucantonio, Giovanna Peruzzi, Miguel Muñoz-Ruiz, Gavin Kelly, Alessandra M. Contino, Roberta Sbrocchi, Simone Battella, Stefania Capone, Antonella Folgori, Alfredo Nicosia, Angela Santoni, Adrian C. Hayday, Francesca Di Rosa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/6f664d1760ab4f819a5be22abf24ec20
Autor:
Kathleen Shah, Muralidhara Rao Maradana, M. Joaquina Delàs, Amina Metidji, Frederike Graelmann, Miriam Llorian, Probir Chakravarty, Ying Li, Mauro Tolaini, Michael Shapiro, Gavin Kelly, Chris Cheshire, Deendyal Bhurta, Sandip B. Bharate, Brigitta Stockinger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Rapid intestinal regeneration after injury is critical to maintain barrier integrity and homeostasis, but must be tightly controlled to prevent tumorigenesis. Here they show that the aryl hydrocarbon receptor is required to terminate the regenerative
Externí odkaz:
https://doaj.org/article/d87470825f124e199a008a818ff3399e