Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Gavan P McNally"'
Autor:
Philip Jean-Richard-dit-Bressel, Jessica C Lee, Shi Xian Liew, Gabrielle Weidemann, Peter F Lovibond, Gavan P McNally
Publikováno v:
eLife, Vol 10 (2021)
Punishment maximises the probability of our individual survival by reducing behaviours that cause us harm, and also sustains trust and fairness in groups essential for social cohesion. However, some individuals are more sensitive to punishment than o
Externí odkaz:
https://doaj.org/article/31dd95f296b14a6d9ac1853f615f3744
Autor:
Philip Jean-Richard-dit-Bressel, Cassandra Ma, Laura A Bradfield, Simon Killcross, Gavan P McNally
Publikováno v:
eLife, Vol 8 (2019)
Our behaviour is shaped by its consequences – we seek rewards and avoid harm. It has been reported that individuals vary markedly in their avoidance of detrimental consequences, that is in their sensitivity to punishment. The underpinnings of this
Externí odkaz:
https://doaj.org/article/aedab6a6e62d460ebadf5717f5aa9743
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173967 (2017)
The orexin/hypocretin system is important for appetitive motivation towards multiple drugs of abuse, including nicotine. Both OX1 and OX2 receptors individually have been shown to influence nicotine self-administration and reinstatement. Due to the i
Externí odkaz:
https://doaj.org/article/e2938f102d20418f9aff60fb684e99f1
Autor:
Asheeta A Prasad, Gavan P McNally
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110385 (2014)
Two experiments used vivo morpholinos to assess the role of orexin/hypocretin in ABA renewal of extinguished alcohol seeking. Rats were trained to respond for alcoholic beer in a distinctive context, A, and then extinguished in a second distinctive c
Externí odkaz:
https://doaj.org/article/b2cb4e238bb24cb19a392e9817db81a6
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111699 (2014)
The lateral habenula (LHb) is a small epithalamic structure that projects via the fasciculus retroflexus to the midbrain. The LHb is known to modulate midbrain dopamine (DA) neurons, including inhibition of ventral tegmental area (VTA) neurons via gl
Externí odkaz:
https://doaj.org/article/9cf8e5121d7541a786f88fa1eda31d1f
Autor:
Caitlin S. Mitchell, Erin J. Campbell, Simon D. Fisher, Laura M. Stanton, Nicholas J. Burton, Amy J. Pearl, Gavan P. McNally, Jaideep S. Bains, Tamás Füzesi, Brett A. Graham, Elizabeth E. Manning, Christopher V. Dayas
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motiva
Externí odkaz:
https://doaj.org/article/e892cfa1b0cc4b1c91328ec5064f90fa
Publikováno v:
Frontiers in Psychiatry, Vol 4 (2013)
Relapse to drug seeking after treatment or a period of abstinence remains a fundamental challenge for drug users. The retrieval – extinction procedure offers promise in augmenting the efficacy of exposure based treatment for drug use and for protec
Externí odkaz:
https://doaj.org/article/331a6f9ddafb4f2691a283c083587a6e
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e58701 (2013)
The hippocampus is part of a neural network which regulates the renewal of fear following extinction. Both the ventral (VH) and dorsal (DH) hippocampus have been shown to be necessary for renewal, however the critical receptors and neurotransmitters
Externí odkaz:
https://doaj.org/article/8c3184d1c313417a81ed5a187b83f39e
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Externí odkaz:
https://doaj.org/article/a2a1d0c00f894d98afc4ebd0332586c7
Autor:
Stephanie Murphy, Metika Collis Glynn, Tiarani N. Dixon, Harvey J. Grill, Gavan P. McNally, Zhi Yi Ong
Publikováno v:
Neuropsychopharmacology. 48:351-361
Hindbrain NTS neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake but the relevant neural phenotypes and pathways remain elusive. Here, we investigated the role of NTS