Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

Autor: Amin Otmani, Gauti Jóhannesson, Rune Brautaset, James R. Tribble, Pete A. Williams

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)

Abstract Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotec

Externí odkaz: https://doaj.org/article/c38a73fa7f8049deb758ef1af5f2a4a5

Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients

Autor: Carola Rutigliani, James R. Tribble, Anna Hagström, Emma Lardner, Gauti Jóhannesson, Gustav Stålhammar, Pete A. Williams

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)

Abstract Neuroinflammation is recognized as a key component of neurodegenerative disease. In glaucoma, a common neurodegenerative disease and the leading cause of irreversible blindness, the evidence for neuroinflammation in patients is lacking. Anim

Externí odkaz: https://doaj.org/article/9cedc7a28e9f4dbc89520469f8b93d6f

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Autor: James R. Tribble, Amin Otmani, Shanshan Sun, Sevannah A. Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Jöe, Emma Lardner, Abinaya P. Venkataraman, Alberto Domínguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Jóhannesson, Robert W. Burgess, Peter G. Fuerst, Rune Brautaset, Miriam Kolko, James E. Morgan, Jonathan G. Crowston, Marcela Votruba, Pete A. Williams

Publikováno v: Redox Biology, Vol 43, Iss , Pp 101988- (2021)

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to

Externí odkaz: https://doaj.org/article/11535b7d2b994327966f83eaacbf9faa

Posture‐dependent collapse of the optic nerve subarachnoid space: a combined MRI and modeling study

Autor: Petter Holmlund, Karen Støverud, Anders Wåhlin, Urban Wiklund, Jan Malm, Gauti Jóhannesson, Anders Eklund

Publikováno v: Acta Ophthalmologica. 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7710e6e8bfd29f8af2d12b7fface3016
https://doi.org/10.1111/j.1755-3768.2022.098

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Autor: Alberto Domínguez-Vicent, James R. Tribble, Emma Lardner, Robert W. Burgess, Jonathan G Crowston, Eirini Kokkali, Marcela Votruba, Melissa Jöe, Gloria Cimaglia, Shanshan Sun, Peter G. Fuerst, Gauti Jóhannesson, Rupali Vohra, Rune Brautaset, Seungsoo Rho, Miriam Kolko, Amin Otmani, Abinaya Priya Venkataraman, Sevannah A. Ellis, Peter A. Williams, James E. Morgan

Publikováno v: Redox Biology, Vol 43, Iss, Pp 101988-(2021)
Tribble, J R, Otmani, A, Sun, S, Ellis, S A, Cimaglia, G, Vohra, R, Jöe, M, Lardner, E, Venkataraman, A P, Domínguez-Vicent, A, Kokkali, E, Rho, S, Jóhannesson, G, Burgess, R W, Fuerst, P G, Brautaset, R, Kolko, M, Morgan, J E, Crowston, J G, Votruba, M & Williams, P A 2021, ' Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction ', Redox Biology, vol. 43, 101988 . https://doi.org/10.1016/j.redox.2021.101988

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. Repleting NAD via dietary supplementation of nicotinam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b7262f22fb5249dc95c75d737e8e19
http://www.sciencedirect.com/science/article/pii/S2213231721001361