Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gautham K Rao"'
Autor:
Gautham K Rao, Albert Wong, Mark Collinge, Joseph Sarhan, Timur O Yarovinsky, Vinod S Ramgolam, Matthias Gaestel, Ruggero Pardi, Jeffrey R Bender
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201103 (2018)
Activation of the β2 integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element (ARE)-bearing mRNAs, by triggering the nuclear-to-cytoplasmic translocation of the mRNA-binding and -s
Externí odkaz:
https://doaj.org/article/ad94a9ab4fcd48998eec75084a4ab756
Autor:
Vinod S Ramgolam, Scott D DeGregorio, Gautham K Rao, Mark Collinge, Sharmila S Subaran, Silva Markovic-Plese, Ruggero Pardi, Jeffrey R Bender
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14450 (2010)
Engagement of the β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), results in stabilization of T cell mRNA transcripts containing AU-rich elements (AREs) by inducing rapid nuclear-to-cytosolic translocation of the RNA-stabilizing prote
Externí odkaz:
https://doaj.org/article/b1333a88b8084887a439447563f996ee
Autor:
Iraj Hosseini, Brett Fleisher, Jennifer Getz, Jérémie Decalf, Mandy Kwong, Meric Ovacik, Travis W. Bainbridge, Christine Moussion, Gautham K. Rao, Kapil Gadkar, Amrita V. Kamath, Saroja Ramanujan
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 660 (2024)
FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and expansion
Externí odkaz:
https://doaj.org/article/2aeee9c733c94287888bd277150996d7
Autor:
Gautham K. Rao, Stephen P. Schauer, Edmond Teng, Joseph Bravo, Reina N. Fuji, Andrea Pfeifer, Yong Ying, Kimberly Scearce-Levie, Jessica Couch, Hilda Solanoy, Paul T. Manser, Andreas Muhs, Han Lin, Daniela Bumbaca Yadav, Oded Foreman, Dongping He, James A. Ernst, Flavia Brunstein, Hai Ngu, Michael C. M. Kwok, Maria Pihlgren, Oskar Adolfsson, Mira Blendstrup, William B. Smith, Priya Chandra, Akash Datwani, Michael Keeley, Danielle DiCara, Robert Brendza, Yanmei Lu, Julien Lafrance-Vanasse, Corinne Foo-Atkins, Jasvinder K. Atwal, Isidro Hötzel, Seung-Hye Lee, Kristin R. Wildsmith, Ruby Chan, Helen Booler, Rich Erickson, Barthélemy Demeule, Geoffrey A. Kerchner, Wilman Luk, Gai Ayalon
Publikováno v:
Science Translational Medicine. 13
Tau has become an attractive alternative target for passive immunotherapy efforts for Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate with disease course and severity better than other disease markers to da
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071601709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b10acaf613d0991449c34dfadb0ee4
https://doi.org/10.1007/978-1-0716-0171-6_12
https://doi.org/10.1007/978-1-0716-0171-6_12
Autor:
Crystal Zhang, Allen Nguyen, Steven T Laing, Gautham K. Rao, Jacqueline McBride, Wendy G. Halpern, Rodney A. Prell, Daniel Sheinson, Stefanie C.M. Burleson
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 169(2)
A theoretical safety concern proposed in the influenza literature is that therapeutic antiviral antibodies could have the potential for antibody-dependent enhancement (ADE) of infection and disease. ADE may occur when virus-specific antibodies at sub
Publikováno v:
International journal of toxicology. 35(3)
The intent of cancer immunotherapy (CIT) is to generate and enhance T-cell responses against tumors. The tumor microenvironment establishes several inhibitory pathways that lead to suppression of the local immune response, which is permissive for tum
Autor:
Matthias Gaestel, Ruggero Pardi, Joseph Sarhan, Jeffrey R. Bender, Vinod S. Ramgolam, Timur O. Yarovinsky, Mark Collinge, Albert J. Wong, Gautham K. Rao
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201103 (2018)
PLoS ONE
PLoS ONE
Activation of the β2 integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element (ARE)-bearing mRNAs, by triggering the nuclear-to-cytoplasmic translocation of the mRNA-binding and -s
Autor:
Norbert E. Kaminski, Gautham K. Rao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:820-829
This laboratory has reported previously that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and cannabinol (CBN) robustly elevate intracellular calcium ([Ca(2+)](i)) in resting human and murine T cells, whereas CP55,940 [5-(1,1-dimethylheptyl)-2-(5-hyd
Autor:
Gautham K. Rao, Norbert E. Kaminski
Publikováno v:
Journal of Leukocyte Biology. 79:202-213
We have reported previously that Δ9-tetrahydrocannabinol (Δ9-THC) treatment of resting human and murine splenic T cells robustly elevated intracellular calcium ([Ca2+]i). The objective of the present investigation was to examine the putative role o