Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Autor: Shalu Sharma, Ananda Kishore Mukherjee, Shuvra Shekhar Roy, Sulochana Bagri, Silje Lier, Meenakshi Verma, Antara Sengupta, Manish Kumar, Gaute Nesse, Deo Prakash Pandey, Shantanu Chowdhury

Publikováno v: Cell Reports, Vol 35, Iss 7, Pp 109154- (2021)

Summary: Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of

Externí odkaz: https://doaj.org/article/31ab0e244fa34537a9b0a97737a04c10

Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Autor: Shantanu Chowdhury, Antara Sengupta, Silje Lier, Meenakshi Verma, Manish Kumar, Shalu Sharma, Deo Prakash Pandey, Shuvra Shekhar Roy, Ananda Kishore Mukherjee, Gaute Nesse, Sulochana Bagri

Publikováno v: Cell Reports, Vol 35, Iss 7, Pp 109154-(2021)
Cell reports

Summary Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d23cda219d3c70d2affd098fe25324d
http://www.sciencedirect.com/science/article/pii/S2211124721004964

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2

Autor: Gaute Nesse, Ananda Kishore Mukherjee, Manish Kumar, Deo Prakash Pandey, Shuvra Shekhar Roy, Sulochana Bagri, Shantanu Chowdhury, Antara Sengupta, Shalu Sharma, Silje Lier, Meenakshi Verma

Tight regulatory mechanisms to maintain repression of human Telomerase (hTERT), the sole protein that synthesizes telomeres, is crucial for normal adult somatic cells. In contrast, enhanced telomerase activity and resulting pathological maintenance o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1a1cf462605b62d59a5db69b6bc6b5

Kinetics of endogenous mouse FEN1 in base excision repair

Autor: Camille Godon, Arjan F. Theil, Pierre-Olivier Mari, Elisabeth Larsen, Guro Flor Lien, Liv Kleppa, Wim Vermeulen, Arne Klungland, Giuseppina Giglia-Mari, Hege Wiksen, Gaute Nesse

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2012, 40 (18), pp.9044-9059. ⟨10.1093/nar/gks673⟩
Nucleic Acids Research, 40(18), 9044-9059. Oxford University Press

The structure specific flap endonuclease 1 (FEN1) plays an essential role in long-patch base excision repair (BER) and in DNA replication. We have generated a fluorescently tagged FEN1 expressing mouse which allows monitoring the localization and kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739ffbdb04bfa08e73cfa88067d7b361
https://doi.org/10.1093/nar/gks673

Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1−/− mice

Autor: Gaute Nesse, Erling Seeberg, Christine Gran, Elisabeth Larsen, Karen Reite, Arne Klungland

Publikováno v: Oncogene. 25:2425-2432

OGG1 (8-oxoguanine DNA glycosylase-1) is one of the main DNA glycosylases present in mammalian cells. The enzyme removes 7,8-dihydro-8-oxoguanine (8-oxoG) lesions, believed to be the most important oxidized lesions due to their relatively high incide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0d9f269a16c14abd158a1f30defc50
https://doi.org/10.1038/sj.onc.1209284