Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gautam Sule"'
Autor:
Bevin C. English, Hannah P. Savage, Scott P. Mahan, Vladimir E. Diaz-Ochoa, Briana M. Young, Basel H. Abuaita, Gautam Sule, Jason S. Knight, Mary X. O’Riordan, Andreas J. Bäumler, Renée M. Tsolis
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Immune cells must be able to adjust their metabolic programs to effectively carry out their effector functions. Here, we show that the endoplasmic reticulum (ER) stress sensor Inositol-requiring enzyme 1 alpha (IRE1α) and its downstream tra
Externí odkaz:
https://doaj.org/article/b52ea6eb6b7147e58bfa67beaabdb258
Autor:
Hui Shi, Alex A. Gandhi, Stephanie A. Smith, Qiuyu Wang, Diane Chiang, Srilakshmi Yalavarthi, Ramadan A. Ali, Chao Liu, Gautam Sule, Pei-Suen Tsou, Yu Zuo, Yogendra Kanthi, Evan A. Farkash, Jiandie D. Lin, James H. Morrissey, Jason S. Knight
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Neutrophil-mediated activation and injury of the endothelium play roles in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap–derive
Externí odkaz:
https://doaj.org/article/841d7563afdf4a2684c13199b322ad80
Autor:
Jason S. Knight, Levi F. Mazza, Srilakshmi Yalavarthi, Gautam Sule, Ramadan A. Ali, Jeffrey B. Hodgin, Yogendra Kanthi, David J. Pinsky
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
ObjectivesCD39 and CD73 are surface enzymes that jut into the extracellular space where they mediate the step-wise phosphohydrolysis of the autocrine and paracrine danger signals ATP and ADP into anti-inflammatory adenosine. Given the role of vascula
Externí odkaz:
https://doaj.org/article/973f655119194c3bbe655ed5cc22bac5
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Neutrophil extracellular traps (NETs) are chromatin-derived webs extruded from neutrophils in response to either infection or sterile stimulation with chemicals, cytokines, or microbial products. The vast majority of studies have characterized NET re
Externí odkaz:
https://doaj.org/article/454d85813475454c8f156ebad3489ed8
Autor:
Gautam Sule, William J. Kelley, Srilakshmi Yalavarthi, Omolola Eniola-Adefeso, Jason S. Knight
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 14-14 (2019)
OBJECTIVES/SPECIFIC AIMS: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received considerably less attention. Mac
Externí odkaz:
https://doaj.org/article/ff14209086cd4b1b99dde8da47f2d835
Autor:
Paula L. Bockenstedt, Srilakshmi Yalavarthi, Andrew P. Vreede, Gautam Sule, William J. Kelley, Alison L. Banka, Kelsey Gockman, Jason S. Knight, Omolola Eniola-Adefeso
Publikováno v:
Arthritis Rheumatol
OBJECTIVE While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received less attention. This study was undertaken to inv
Autor:
James H. Morrissey, Stephanie A. Smith, Yu Zuo, Chao Liu, Qiuyu Wang, Yogendra Kanthi, Pei-Suen Tsou, Srilakshmi Yalavarthi, Diane Chiang, Jiandie D. Lin, Jason S. Knight, Gautam Sule, Alex A. Gandhi, Evan A. Farkash, Hui Shi, Ramadan A. Ali
Publikováno v:
medRxiv
JCI Insight
JCI Insight
Neutrophil-mediated activation and injury of the endothelium play a role in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap/NET-der
Autor:
Yu Zuo, Jacqueline A. Madison, Yogendra Kanthi, Hui Shi, Melanie Zuo, Yue Shi, Michael D. Maile, Alyssa Harbaugh, Srilakshmi Yalavarthi, Sherwin Navaz, Kelsey Gockman, Claire K Hoy, Jason S. Knight, Alex A. Gandhi, Jintao Wang, Gautam Sule
Publikováno v:
medRxiv
Objectives Patients with coronavirus disease 19 ( COVID-19 ) are at high risk for fibrin-based occlusion of vascular beds of all sizes. Considering endothelial cell activation has regularly been described as part of the COVID-19 thrombo-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224471b456e56cf9bfffd57a4322709c
https://europepmc.org/articles/PMC7836141/
https://europepmc.org/articles/PMC7836141/
Autor:
Vinita Yadav, Sean P Lezak, Stephanie A. Smith, Melanie Zuo, Srilakshmi Yalavarthi, Wrenn Woodard, Yu Zuo, Shanea K. Estes, Kelsey Gockman, Jason S. Knight, Hui Shi, Ramadan A. Ali, Jacqueline A. Madison, Yogendra Kanthi, Njira L Lugogo, Jintao Wang, James H. Morrissey, Gautam Sule, Alex A. Gandhi
Publikováno v:
Science Translational Medicine
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based blockages in the small blood vessels of patients who succumb to the disease. Antiphospholipid syndrome is an acquire
Autor:
Johann E. Gudjonsson, Paul A. Steffes, Basel H. Abuaita, J. Michelle Kahlenberg, Andrew T. Fernandes, Deepika Pandian, Gautam Sule, Mary X. D. O'Riordan, Shanea K. Estes, Jason S. Knight, Craig J. Dobry
Publikováno v:
J Clin Invest
Neutrophils amplify inflammation in lupus through the release of neutrophil extracellular traps (NETs). The endoplasmic reticulum stress sensor inositol-requiring enzyme 1 α (IRE1α) has been implicated as a perpetuator of inflammation in various ch